PubMed Health⌕ Search

Biomedical subjects

H Dutau

Publications and source records attributed to H Dutau.

14 recordsLinked to original sources

[Bronchoscopy in the diagnosis of lung cancer: an evaluation of current practice].

INTRODUCTION: Bronchoscopy is frequently practised by respiratory physicians, particularly when there is a suspicion of lung cancer. However, few guidelines are available and practice varies widely. BACKGROUND: Studies of current practice are few and unstandardised. Few data are available regarding equipment or procedure (information, prior investigations, environment, standardised reporting etc.). The evaluation of new techniques such as endobronchial ultrasound, autofluorescence bronchoscopy, transbronchial needle aspiration (TBNA) has been covered in recent publications. These evaluations are often undertaken without rigourous methodology (retrospective studies) but underline the feasibility of these techniques. Some, especially TBNA are nevertheless underused in practice. In the published studies evaluating practice the results of these investigations are often similar to those obtained in clinical trials even if a learning period is necessary. Complications are rare. Few studies of cost effectiveness are available but they support the use of these new techniques. VIEWPOINT: A national study under the aegis of the SLPF (French Respiratory Society) is necessary to obtain comprehensive and reliable data on the practice of bronchoscopy in the investigation of lung cancer. CONCLUSIONS: Studies evaluating current practices are few and unstandardised, and probably give only a partial survey of the success achieved and the difficulties encountered by respiratory physicians in their clinical routine.

Bronchoscopy↗

Prevalence of asthma and rhinitis in relation to long-term exposure to gaseous air pollutants.

The relationship between long-term exposure to air pollutants, especially with regard to photochemical air pollutants, and asthma prevalence in developed countries is controversial. The objective of this cross-sectional survey was to compare mean levels of the main gaseous air pollutants and prevalence rates of rhinitis, asthma, and asthmatic symptoms. It included 2,445 children from the 8th and 9th school grades who had been living for at least 3 years in an area where some communities undergo the heaviest photochemical exposure in France. Data on rhinitis, asthmatic symptoms, and asthma prevalence were gathered with the ISAAC paper and video questionnaires. The relation between level of air pollutants and asthma was assessed first by comparison of crude prevalence rates (chi-square test), and then by simple regression analysis and multiple logistic regression analysis. No consistent association between mean SO2 and NO2 levels, and prevalence of rhinitis, asthma, or asthmatic symptoms could be demonstrated. In contrast, there were statistically significant associations between prevalence of asthmatic symptoms and mean ozone O3) concentration. The interpretation of such findings is not straightforward, as these symptoms can be interpreted either as respiratory irritation due to exposure to nonspecific airway stimuli or as a true asthmatic state. Additional studies are required to clarify this important issue. In conclusion, this large cross-sectional epidemiologic survey performed in an area of high photochemical air pollution did demonstrate statistically significant associations between the prevalence of asthmatic symptoms and mean O3 concentration.

Adolescent↗

[Epidemiology of respiratory allergies: current data].

Respiratory allergic diseases include seasonal allergic rhinitis or hay fever, perennial allergic rhinitis and allergic asthma. Prevalence of asthma is difficult to assess through epidemiological questionnaires. In France hay fever roughly affects 6% of children and 18% of teenagers and nasal allergies, more than one fourth of young adults. Prevalence of asthma is equal to 10 to 15% in teenagers and 7 to 9% in young adults. Risk factors include genetic as well as environmental factors. The role of the former have been exemplified in family studies, especially twin studies, and surveys of inbred populations. Environmental factors can be allergic or non-allergic. The influence of allergenic exposure on sensitization, occurrence and severity of respiratory allergic disease is well documented. The triggering influence of non-allergenic factors on established allergic diseases is also clear. In contrast, their implication in allergic sensitization and occurrence of allergic diseases need to be clarified.

Adult↗

[Evaluation of a questionnaire on the home environment of asthmatic patients].

Indoor environment outpatient asthmatics plays a major role in modulating asthma severity. Therefore many surveys devoted to studying risk factors for asthma include a questionnaire about housing characteristics. However no such questionnaire has been to date validated. In this study, we tried to validate such a questionnaire by comparing answers of a group of asthmatics outpatient to a questionnaire to de visu finding performed by a field worker during a home visit. Thirty asthmatic patients were included in the study. Housing characteristics were generally correctly acknowledged. Questions on the heating system should be clearly and simply formulated. Energetic supply of stoves and ventilation system is not always known. In the field of house equipment, especially bedding, photographs or drawings can be useful.

Asthma↗

The prevalence of reported asthma is independent of exposure in house dust mite-sensitized children.

In areas with low house dust mite (HDM) allergen exposure, both mite sensitization and asthma prevalence are low. In most other areas, HDM allergen exposure is higher than the threshold for sensitization. In this setting, is HDM allergen exposure a factor which is causally related to the development of asthma in HDM-sensitive individuals? To answer this question, the cumulative prevalence of asthma was evaluated in a group of 157 schoolchildren, aged 10 and 11 yrs, who were allergic to HDM allergen, and compared it with HDM allergen exposure and atopic status, using univariate and multivariate analysis. HDM allergen levels were measured in mattress dust using an enzyme-linked immunosorbent assay (ELISA) method. Of mattress dust samples, 94% had an HDM allergen level >2 microg x g dust(-1). Atopy was evaluated by means of skin prick tests using five common allergens. Among the predictive variables studied by means of univariate analysis, only the number of positive skin tests and male sex correlated with asthma prevalence, but not HDM allergen exposure. Logistic regression analysis also demonstrated that the number of positive skin tests correlated with asthma prevalence (odds ratio (OR)=1.38, p=0.05), whereas the OR for HDM allergen exposure was 1.0. This survey suggests that, in a geographical area with high HDM allergen exposure, asthma prevalence is not linked with HDM allergen levels.

Allergens↗

Role of allergens in the natural history of childhood asthma.

This review article deals with the role of allergens in the natural history of asthma. Several studies clearly demonstrate a strong relationship between allergen exposure, especially mite-allergen exposure, and risk of sensitization. Those studies have led to the proposed threshold equal to 2 micrograms/g dust. However, more recent evidence shows that there is no threshold for sensitization, especially in children born to atopic parents. As far as occurrence of asthma is concerned, geographical comparisons of asthma prevalence across Europe, Australia or in other populations with contrasted exposure to mite allergens do show such a relationship. The latter is not exemplified in studies performed within the same geographical area, probably because the exposure categories are not contrasted enough. Finally, asthma severity in mite sensitive asthmatics is partly modulated by allergen exposure but repeated exposure to low amounts of allergen can trigger disease activity. In conclusion, allergen exposure is involved at each step of the natural history of asthma. Even low doses can play a significant role. Thus avoidance methods, in order to be efficient in primary and secondary prevention, should lead to a drastic decrease in allergenic exposure.

Allergens↗

[Risk factors in severe asthma].

Risk factors for severe acute asthma involve the patient, the environment and the society in general. In addition, there are strong interrelationships between these factors. Personal characteristics linked to acute severe asthma include age (teenagers), denial leading to poor compliance, depression with atypical symptoms in children, and some medical features of asthma associated with increased severity. Environmental factors include airborne allergens, infections, irritants such as air pollutants and passive smoking. Life events have not been extensively studied but are likely to play a predominant role. The social setting, particularly the health care system, acts as an interface between the patient and the environment. Most all asthma deaths are avoidable and related to dysfunctions in the health care system.

Adolescent↗

[Pollution and allergy: the epidemiological data].

This area is controversial, mostly because of disagreement between experimental and epidemiological data. Even though modulation of asthma by the level of atmospheric pollution has been well shown by panel and ecological studies, the relationship between pollution and genesis of allergic diseases has not been confirmed by epidemiological studies. Comparison of the frequency of asthma in urban and rural surroundings in general shows, in the urban environment, an advantage of irritation symptoms but not for asthma. In contrast, the prevalence of atopy seems higher in the urban environment, which is perhaps a reflection of a different way of life, like that shown in east-west studies. Several recent investigations showed that at the centre of a development additional respiratory symptoms related to the intensity of automobile traffic, but no relationship was shown with atopy. In the same way, no epidemiological investigation has shown a relationship between automobile pollution and prevalence of atopy. Thus, at present no solid elements exist to support an increase of the frequency of asthma and especially atopy, in a relationship with modern atmospheric pollution, essentially of automobile origin.

Air Pollutants↗