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Biomedical subjects

H E Adrogué

Publications and source records attributed to H E Adrogué.

2 recordsLinked to original sources

Prevalence of hypertension in junior high school-aged children: effect of new recommendations in the 1996 Updated Task Force Report.

The 1996 "Update on the 1987 Task Force Report on Blood Pressure in Children and Adolescents" adopted the fifth Korotkoff phase to define diastolic blood pressure and added height, in addition to age and gender, to develop new standards for blood pressure (BP) in children. The present study was performed to determine whether these changes altered the previously reported prevalence of hypertension in junior high school-aged children. Blood pressure screening was conducted in 19,452 fifth to eighth grade students. All students with a systolic blood pressure more than the 70th percentile had their BP measured a second time (rescreening). Using the 1996 criteria, systolic hypertension was found in 2.7% and diastolic hypertension in 2% after the screening. After the rescreening, systolic hypertension had fallen to 0.8% and diastolic hypertension to 0.4%. The prevalence of systolic hypertension was slightly higher and diastolic hypertension slightly lower than in 1987. These reports show that the overall prevalence of hypertension (1%) using the 1996 Updated Task Force criteria is similar to the prevalence using the original 1987 criteria. These results also confirm the importance of the Task Force recommendation that multiple BP measurements should be obtained before making a diagnosis of hypertension.

Adolescent↗

Acid-base physiology.

Acid-base homeostasis involves chemical and physiologic processes responsible for the maintenance of the acidity of body fluids at levels that allow optimal function of the whole individual. The chemical processes represent the first line of defense to an acid or alkali load and include the extracellular and intracellular buffers, whereas the physiologic processes modulate acid-base composition by changes in cellular metabolism and by adaptive responses in the excretion of volatile acids by the lungs and fixed acids by the kidneys. The need for the existence of multiple mechanisms involved in acid-base regulation stems from the critical importance of the hydrogen ion (H+) concentration on the operation of many cellular enzymes and function of vital organs, most prominently the brain and the heart. The task imposed on the mechanisms that maintain acid-base homeostasis is large, since metabolic pathways are continuously consuming or producing H+, and the daily load of waste products for excretion in the form of volatile and fixed acids is substantial. We review the determinants of the acidity of body fluids, the mechanisms that maintain normal acid-base composition, and the overall defense to disruption in acid-base equilibrium. Specific topics include an examination of the scales of acidity, buffer systems, intracellular acid-base regulation, excretion of acids, alkali and acid loading, and normal acid-base composition. The limitations of arterial blood sampling in the assessment of acid-base status are also evaluated.

Acid-Base Equilibrium↗