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Biomedical subjects

H E Cannon

Publications and source records attributed to H E Cannon.

4 recordsLinked to original sources
PubMed1978

Are paranoid schizophrenics biologically different from other schizophrenics?

Two studies were undertaken to verify the presence of lowered platelet monoamine oxidase activity in chronic schizophrenia. In the first study, a retrospective chart analysis, the mean platelet activity of patients with chronic schizophrenia (7.73+/-0.64 nmol of benzylaldehyde product per 10(8) platelets per hour [S.E.M.]) differed significantly from that of normal controls (12.13+/-0.2, P less than 0.001). Chronic paranoid schizophrenics (4.81+/-0.46) differed significantly from chronic nonparanoid schizophrenics (8.6+/-0.75, P less than 0.03). A separate prospective study confirmed significantly lower values for monoamine oxidase activity in chronic schizophrenic patients diagnosed as paranoid (5.97+/-1.17) or as having secondary paranoid features (6.28+/-0.71) as compared to chronic nonparanoid schizophrenics (9.81+/-0.87, P less than 0.001). Chronic paranoid schizophrenia may be a separate disorder from the other chronic forms of schizophrenia, and this difference may be related, at least in part, to biochemical characteristics.

Blood Platelets↗
PubMed1978

Burned-out schizophrenia: evidence for age effects on schizophrenic symptomatology.

The long-term outcome of chronic schizophrenia has classically been accepted to be pessimistic, most often leading to a terminal demented state. An examination of recent literature that has followed schizophrenic patients into the involutional years is not so convincing. The few studies that so report upon elderly schizophrenics demonstrate substantially altered symptomatology, most often coinciding with the onset of the involutional years (ages 55-64). This under-investigated phenomenon has real implications for the continuing need of institutionalization and/or pharmacologic treatment for these older schizophrenic patients and warrants rigorous investigation.

Aged↗