AN ELECTROENCEPHALOGRAPHIC STUDY OF SOME STRUCTURAL ASPECTS OF D-AMPHETAMINE ANTAGONISM IN PHENOTHIAZINE AND RELATED COMPOUNDS.
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Biomedical subjects
Publications and source records attributed to H E HIMWICH.
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Chlorpromazine was found to have an antagonistic action against the electroencephalographic (EEG) alerting produced in rabbits by cholinergic agents, particularly eserine salycilate and acetylcholine chloride. This cholinolytic action occurs at a prepontine, precollicular level where adrenergic agents fail to elicit EEG alerting. These results emphasize the importance of cholinergic mechanisms in EEG alerting.
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