Scintillation proximity assay (SPA)--a new method of immunoassay. Direct and inhibition mode detection with human albumin and rabbit antihuman albumin.
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Animals↗
Biomedical subjects
H E Hart
Publications and source records attributed to H E Hart.
Scintillation-proximity assay of antigen-antibody binding kinetics: concise communication.
Tritiated latex particles and scintillant latex particles have been covalently coated with an antigen (human albumin) and both types of particles are than combined in dilute aqueous suspensions. The formation of antibody-induced dimer and higher-order aggregation resulted in scintillations that could be measured in a standard liquid-scintillation counter, energy-gated for H-3. Rabbit anti-human antiserum was easily detected at a titer of 1:10(6). Human albumin, in the inhibition mode, was also easily detected at 0.1 ng/ml. Since the samples are nondestructively assased, it was possible to examine the kinetics of aggregation under a variety of conditions.
Albumins↗
Three-dimensional imaging of multimillimeter sized cold lesions by focusing collimator coincidence scanning (FCCS).
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Mathematics↗
Vascular and extravascular calcium interchange in man determined with radioactive calcium.
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Adult↗
Resolution characteristics of tomographic rotating collimator systems.
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Biomedical Engineering↗
A tomographic magnifying collimator system for the gamma camera.
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Mathematics↗
Magnifying collimators.
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Radiographic Magnification↗
Discrete formulation and error minimization in applying the integro-differential equation approach to mono-compartment data.
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Computers↗
Comparative resolution of single gamma counting and coincidence counting in focusing collimator scanning systems.
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Methods↗
Analysis of tracer experiments. 8. Integro-differential equation treatment of partly accessible, partly injectable multicompartment systems.
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Biological Transport↗
Geometric efficiency and other performance characteristics of focusing collimators.
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Mathematics↗
Analysis of tracer experiments. VII. General multi-compartment systems imbedded in non-homogeneous inaccessible media.
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Mathematics↗
Analysis of tracer experiments. V. Integral equations of perturbation-tracer analysis.
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Biological Transport↗
Thermal dissociation of antigen-antibody-antigen-like systems.
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Antigen-Antibody Complex↗