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Biomedical subjects

H Ehringer

Publications and source records attributed to H Ehringer.

At least 109 records · Page 6Linked to original sources

Prevention of postvenographic thrombosis by heparin flush: fibrinogen uptake measurements.

The incidence of postphlebographic venous thrombosis was investigated by 125I-labeled fibrinogen uptake tests in 60 patients whose veins were flushed with saline solution containing 10,000 IU of heparin after leg phlebography. Ionic methylglucamine iodamide was used as the contrast medium. In six patients superficial thrombophlebitis extending from the contrast-medium injection site was observed after phlebography. The incidence of deep venous thrombosis was 3.3%, significantly less than that reported for studies using triiodinated ionic contrast media without flushing the veins with a heparin solution. It is comparable to the incidence of venous thrombosis reported after using nonionic contrast media. The authors conclude that flushing the veins with heparinized saline solution can improve the safety of phlebography considerably.

Adult↗

[Acute venous thrombosis: localization, extent and aetiology with special consideration of paraneoplasia].

Among 279 consecutive patients (average age 53.8 years) with acute venous thrombosis, "complete" or "nearly complete" search for neoplasm was undertaken in 93 (average 60.6 years), "not complete" search in 186 (average 50.1 years). Subsequently the patients were followed regularly for possible malignant tumour (average follow-up period 36.9 months). In the group as a whole the following causes of thrombosis were identified: contraceptives 9.3%; post-operative 9%; malignant tumour diagnosed immediately or within 12 months 5.8%; traumatic 5%; immobilization 3.2%; post-partum 2.9%; diverse other causes 8.2%; unknown 59.5%. Neoplasm was found in 12.9% of 93 somewhat older "completely" examined patients. Taking into account age, 7.8% of all patients over 50 years developed thrombosis in association with neoplasm. In 6 of 16 patients with malignant tumour the venous thrombosis followed a particular course. Extensive thromboses in several bouts predominated. In 48.4% there were three-bout thromboses, in a further 27.4% four-bout thromboses involving also the pelvic vein. Isolated lower-leg venous thrombosis occurred in 9.2%, while the remaining one or multiple-bout thromboses occurred only in a few. Massive pelvic and leg vein thrombosis occurred in 43% of patients with malignant neoplasm, much more frequently than in those without neoplasm.

Acute Disease↗

[Transaminase increase: a largely unknown side-effect of heparin treatment (author's transl)].

GOT, GPT and some other enzyme levels were measured systematically in 46 patients receiving subcutaneous heparin treatment. The heparin dosage varied between 5,000 and 15,000 IU, given every eight hours. During heparinisation a rise in GPT (average maximal values 67.0 +/- 7.3 U/l on the eighth treatment day) occurred in 89% of patients, while a rise in GOT (mean maximal values 39.7 +/- 3.9 U/l on the fifth treatment day) occurred in 82%. On reaching maximal value, enzyme activity decreased to the initial value despite continuing heparin treatment. A certain dependence of the incidence and (or) extent of the transaminase increase on heparin dosage was noted, especially comparing low-dose and full heparinisation. An increase in gamma-GT during subcutaneous heparinisation occurred in 37% of patients, while there was no significant change in alkaline phosphatase and lactate dehydrogenase.

Adolescent↗

[Enlargement and complications of symmetrical aneurysms of the femoral artery--a case report (author's transl)].

The enlargement of symmetrical aneurysms of the femoral artery was followed up angiographically in a 67 year-old patient. The left aneurysm caused compression of the femoral vein and disturbance of venous outflow; surgical removal of the aneurysm, followed by Gore Tex bypass, resulted in a normalisation of arterial inflow and venous outflow. Rupture of the right aneurysm was immediately treated as a surgical emergency and a Gore Tex bypass was implanted on this side too. This unusual case and its complications and treatment is compared with, and discussed in the light of reports of similar cases in the literature.

Aged↗

Acute action of guanfacine on peripheral circulation in hypertensive patients: measurements of arterial flow of the calf and of the forefoot, of venous capacity of the calf, of the blood pressure and of the heart rate.

1. The acute action of an intravenous infusion (5 min) of guanfacine in doses of 0.01, 0.02 and 0.04 mg/kg on peripheral circulation was studied in five hypoertensive patients and compared with a placebo in a randomized study. The observations were combined for 2 h after drug administration. 2. Two phases of drug action were seen during and immediately after the administration of guanfacine; a dose-dependent decrease in blood flow mainly of the forefoot but also in the calf was combined with an increase in systolic and diastolic blood pressures and a decrease in heart rate. Peripheral resistance was increased in this phase. Later, an increase in blood flow to the foot combined with a tendency towards a decrease in blood pressure were observed. 3. These preliminary results show that this second phase of action of guanfacine is dependent on the dose given.

Adult↗

[Automatically controlled angiological tilting table for standardised plethysmographic evaluation of partial functions of the veins of the leg: method and normal values].

A preadjustible, electrically driven, automatically controlled tilting procedure is prevented by fixing them below with an adjustible bicycle saddle (passive orthostasis during the measurement) and above with shoulder pads. Automatic standardized tilting by means of this table with simultaneous plethysmographic registration (strain gauges or air-filled plethysmographs) of the volume changes of the calf or/and the forefoot results in objective quantitative parameters of the following venous partial functions: A) Efficiency of venous outflow (tilting from head up 20 degrees to head down 60 degrees) and B) Venous insufficiency (swelling more than normal arterial inflow during tilting from head down 20 degrees to head up 60 degrees). The very good reproducibility of this method is shown. The range of normal values in healthy subjects is compared with those of patients suffering from different venous diseases of the legs. The method enables long-time observations by means of objective functional parameters.

Humans↗