Biomedical subjects

H Ekberg

Publications and source records attributed to H Ekberg.

112 records · Page 7Linked to original sources

PubMedDate not supplied

Angiography as diagnostic, prognostic and therapeutic tool in liver metastases from a colo-rectal primary tumor.

Angiograms from 60 patients with liver metastases from colo-rectal carcinoma were reviewed in retrospect to find prognostic parameters. All patients were treated with intraarterial cytostatic drugs. Patients with a small tumor mass in the liver survived significantly longer than those with a huge tumor burden. A longer survival was seen also in patients who developed occlusion of the hepatic arterial tree. When the tumor showed reduction in size or was stationary at the follow-up angiographic examinations after institution of therapy survival was markedly improved. When compared with the findings at laparotomy, angiography adequately demonstrated tumor growth in the right lobe of the liver but repeatedly failed to do so in the left lobe. In 14 patients computed tomography was also performed. Tumor localization by CT corresponded well with the findings at laparotomy and was thus more accurate than the results by angiography. Information about tumor volume and number of tumor nodules was approximately the same with the two methods.

Angiography↗

PubMedDate not supplied

Computed tomographic angiography of the liver via the coeliac axis.

Sixty computed tomographic angiographic (CTA) examinations of the liver were performed with contrast injection into the coeliac axis. Data from both an arterial and a portal venous phase were recorded. In 41 patients it was possible to compare the results of CTA with palpation of the liver during laparotomy. The results from CTA and laparotomy were the same in 35 patients (85%). In one patient CTA disclosed verified liver lesions not diagnosed at laparotomy. There were 2 false negative and 3 false positive CTA examinations. In the remaining 19 patients, a clinical follow-up period of at least 6 months was used to evaluate the results of CTA. In the 7 patients in whom CTA showed benign lesions or a normal liver parenchyma, the clinical follow-up revealed no evidence of tumour growth in the liver.

Follow-Up Studies↗

PubMedDate not supplied

Site and number of liver tumors recorded at angiography and computed tomography compared with the findings at laparotomy and of resected liver specimens.

Angiography and computed tomography (CT) were performed in 96 patients before laparotomy for an intended liver resection. Of these, 73 patients underwent liver resection, from a local excision to a trisegmentectomy. The accuracy of angiography in tumor localization was 77 per cent when the results were compared with the findings at laparotomy and from resected specimens. With CT the accuracy was 85 per cent. In 47 patients an analysis of the number of tumor nodules was possible. There were 76 nodules, and 42 (55%) were correctly identified by angiography and 58% (76%) by CT. Thirty-four tumor nodules were not seen at angiography, with the majority of these situated in the left liver lobe. At CT, 18 nodules were not observed, about equal numbers in right and left lobes. Five lesions thought to be present at angiography (9 at CT), could not be verified upon inspecting the resected specimens. Neither angiography nor CT seems to be reliable enough for an accurate prediction of resectability of liver tumors prior to laparotomy.

Adult↗

PubMedDate not supplied

Radiologic diagnosis of liver metastases in colo-rectal carcinoma. Prospective evaluation of the accuracy of angiography, ultrasonography, computed tomography and computed tomographic angiography.

To evaluate the accuracy of radiologic methods in liver metastases from colo-rectal carcinoma, a prospective investigation of 71 patients was performed. These patients were examined by angiography, ultrasound (US), computed tomography (CT) and computed tomographic angiography (CTA). The primary aim of the investigation was to determine the accuracy of CTA. The results of these examinations were then compared with the results from inspection and palpation of the liver at laparotomy. An analysis of liver tumor distribution, as well as a lesion-by-lesion analysis, was performed. In 20 patients, tumor growth was found in the liver in 36 lobes/segments at laparotomy. Three patients called false positives (angiography 2, US, CT and CTA 3 patients) turned out to be true positives since the lesions were overlooked at operation. The changes in sensitivity obtained when these patients are considered are given in parentheses. Of the lobes/segments affected by tumor growth at surgery, angiography revealed 47 (48) per cent, US 69 (71) per cent, CT 80 (82) per cent and CTA 83 (84) per cent. At a lesion-by-lesion analysis, angiography showed 33 per cent, US 69 per cent, CT 61 per cent and CTA 76 per cent of the lesions. Because of a larger number of false positives recorded with CTA compared with CT the former examination is not suitable as a single method for evaluating resectability of liver metastases.

Adult↗