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Biomedical subjects

H Elias

Publications and source records attributed to H Elias.

At least 19 recordsLinked to original sources

[Substitute drug-assisted treatment of drug dependent patients in general practice].

An evaluation carried out on 15. 12. 1989 of the treatment of drug addicts with substitute substances in my practice, confirms the palliative effect of a substitute substance reported in other countries. The mortality rate of substituted addicts is below that of untreated patients. Compliance with treatment using dihydrocodeine is lower than that seen with methadone, which, at least in part, is probably due to the fact that the patients have to pay for the substitute substance themselves. Voluntary acceptance of inpatient long-term treatment was 3% a year, and was thus better by a third in my patients as compared with untreated drug addicts.

Ambulatory Care

Nuclear fragmentation in colon carcinoma cells.

The nuclei of the epithelial cells of well differentiated adenocarcinoma of the large intestine show characteristic appendages, the nucleotesimals, connected with the main nucleus by lamellar bridges. We interpret this phenomenon as being the result of a hitherto unknown type of amitosis that permits rapid cancer growth in spite of a low mitotic index.

Adenocarcinoma

Stereology of parallel, straight, circular cylinders.

New stereological formulae are developed to quantify an array of straight, parallel, circular cylinders. The problem arose through the necessity to determine the average length and surface density of the crypts of the large intestine. These crypts or glands have the shape of test tubes.

Animals

Three-dimensional structure identified from single sections.

Errors in the identification of objects have been made frequently because of faulty interpretation of their flat images or sections. Such errors are perpetuated through a strange psychological chain reaction. 1) The first author who observes sections of an object, although presenting faithful pictures of sections of it, identifies its shape incorrectly. Such an initial mistake may be due to identification of the flat image with the object itself or to failure to consider the shape of the image as a function of the shape of the real object and the angle and level of cutting. 2) The first author describes verbally his personal concept of the object. 3) The reader reads the text of a publication before or without examining the pictorial evidence. 4) The reader's belief in the authority of the printed word immunizes him against critical evaluation of the evidence. 5) The reader regards a published opinion as a "fact." 6) A mechanism of suppression of new evidence is set up in the brain of the reader in favor of previously published, verbalized concepts. His brain unconsciously rejects new concepts that might arise intracerebrally. The printed word supersedes visual evidence. 7) A secondary mechanism parallels steps 3 to 6. An observer notices an unfamiliar figure in the microscope. Following established procedures for scientific investigations, he refrains from forming an opinion about his observation. Instead he rushes to the library searching for similar, published observations. If he finds a previous report about a similar shape, he accepts it as a "fact" and he "confirms" the previously printed viewpoint. Let me interject a personal experience concerning this mechanism. I investigated the arrangement of blood vessels in the human liver by means of corrosion preparations. The work was divided between an assistant and me. He was assigned the task of preparing drawings of two specimens. In his drawings he showed a structure which was absent from the specimens but had been described in a previous publication. This article shows simple ways for correct initial identification of shape and structure and for the breaking of the reverberating circuit of erroneous thinking.

Animals