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Biomedical subjects

H F Bao

Publications and source records attributed to H F Bao.

8 recordsLinked to original sources
PubMed1992

An image analysis on pathological changes in pulmonary arteries in chronic obstructive pulmonary disease.

The changes in small pulmonary arteries of 15 patients with chronic obstructive pulmonary disease (COPD) were investigated by light and electron microscopy, image analysis etc. It was found that the structural changes in the pulmonary arteries of the patients with COPD were characterized by muscularization of non-muscular arterioles, media hypertrophy, longitudinal smooth muscle bundles in the intima and fibrosis in both the media and intima. In the course of time, these lesions resulted in thickening of the arterial wall and narrowing of the lumen. Clinically, the patients developed pulmonary hypertension causing cor pulmonale. Initial data on the structure of arterial wall at different segments were compared statistically. There was very significant difference between the COPD and control groups (P less than 0.001). By Fisher's auto-classification (automatic pattern recognition), the rate recognized was correct in more than 90% in the small arteries of less than 200 microns in diameter. It is suggested that these arteriolar changes are closely related to pulmonary hypertension. The image analysis showed that the ratios of MWA/MVA and MWT/MD were of great value in evaluating the degree of the changes in the arteries of the patients with COPD.

Female↗
PubMed1991

Reconstruction of the frequency distribution of A- and B-cell size in the pancreatic islets from several animal species--an important stereological operation in QMSOC.

The stereological algorithms for the conversion of the profile-size frequency distribution (PSFD) observed in histological section to the sphere-size frequency distribution (SSFD) in three-dimensional space was developed to a computer program and its practical application was described in this paper. The reconstructions of SSFD were based on the data of PSFD of A- and B-cells measured in sections of the pancreatic islets from ophiocephalus argus, toad, chicken, cat, rabbit and rat. The sizes of both profile and sphere were expressed by their caliper diameters. The experimental results showed that the patterns of SSFD of A- and B-cells from six animal species were somewhat different, and that all the peaks of them, however, occurred in the range from 6 to 12 microns in caliper diameter.

Algorithms↗
PubMed1991

Information medicine and its primary functions of exploitation of medical resources.

The aim of this paper is to continue the discussion on the defects of the structures of medical resources and their applicability at the present time, and then to design the qualitative networklike subsystem of the new research Quantitatively Medicine Simulating and Operating by Computer (QMSOC) and a five-library model of the new knowledge-base of QMSOC. Finally, a set of results from the primary functions of exploitation of pancreas-glucagon-insulin information by QMSOC are presented.

Databases, Factual↗
PubMed1990

The new functions of quantitatively medicine simulating and operating by computer (QMSOC).

The preliminary results from integration-evaluation on a set of 310 binary relations in current data base of the new research Quantitatively Medicine Simulating and Operating by Computer (QMSOC) are presented in this paper. Through the function derived from the reciprocity in analysis of conditions, subjects and objects, in the given biomedical events, the number of routes for observation of glucagon and insulin was increased by 38.1% and 136.4% over the conventional object-oriented searching, respectively. The intersection operation of condition sets indicates that it is possible through QMSOC to increase markedly the degree of definity of causality of biomedical events. 70 new binary quantitative relations have been created through operator 1, achieving an increment of 22.6% over the total of original binary relations in the data base. The characteristics and the significance of QMSOC are discussed.

Causality↗
PubMed1989

Structure characteristics of QMSOC and the relevant operators.

This article presents a further description on the background, significance, and structure characteristics of Quantitative Medicine Simulation and Operation by Computer (QMSOC). Also some basic operators were recommended for calculations of biomedical events such as estimation of substance concentrations, exploration of etiology, evaluation of biomedical effects, etc. At last some differences of QMSOC from other artificial intelligent systems in the medical field were discussed.

Computer Simulation↗
PubMed1988

Application of the method of multiple thresholding to white blood cell classification.

A new method of image segmentation based on the principle of multiple grey level thresholding has been applied to a data set consisting of 1149 white blood cells of 13 different, clinically important types, randomly chosen on 20 blood smears from leukemia patients. Classification of these cells on the basis of quantitative measurements in the segmented images yields an accuracy of 82.6%. Some of the erroneous classifications must be attributed to intrinsic problems in the assignment of a priori labels. Correcting for such cases, the performance of the method, as measured on the present data set, increases to 89.8%. This illustrates the practical applicability of the segmentation method in automated white blood cell and possibly other cytological and histological analysis systems.

Acute Disease↗
PubMedDate not supplied

Automated white blood cell classification revisited.

A novel approach to the problem of automated white blood cell classification is described. Whereas in most earlier attempts the segmentation of the cells has been recognized as the most difficult and most critical step in the sequence of operations resulting in the classification, the method described here eliminates the necessity of the detection of the contour of the nucleus and of the cytoplasm, and is therefore less sensitive to such disturbing factors as the presence of granules, of other cells touching the cell of interest, etc. The multiple sequential threshold method to be described here in two slightly different variants yields a correct classification rate of 94.7% for a 4 class problem (90 cells in the test set), and 91.8% for an 8 class problem (279 cells in the test set). Both experiments include immature cell types.

Densitometry↗