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Biomedical subjects

H F Koch

Publications and source records attributed to H F Koch.

12 recordsLinked to original sources
PubMed1978

Biochemical treatment of precancerous oral lesions: the effectiveness of various analogues of retinoic acid.

Leukoplakia is neither a clinical, aetiological nor histopathological entity. Therefore treatment is difficult particularly in multifocal and advanced lesions. Since 1970, we have tested the therapeutic effect of different derivatives of all-trans-retinoic acid. The study includes 75 cases with homogeneous leukoplakia without or with minimal epithelial dysplasia. Over 60% of the cases treated showed positive early results. In follow-ups from 1 to 6 years about 45% of cases showed complete or partial remission. The rest showed relapses or even progression. In cases with recurrence without changes in the morphological characteristics, positive effects were achieved with 1 to 4 repeated courses of therapy. All derivatives of retinoic acid tested so far have shown undesirable side effects with systematic manifestations or local symptoms: interruption of treatment (4) or reduction of dosage (9) were unavoidable for that reason. Regarding the side effects, retinoic acid should only be given under clinical supervision. Of the derivates tested to date, aromatic retinoid seems to have the best curative potential in homogenic leukoplakia.

Humans↗
PubMed1977

Irregular cervical dissemination of tumours of the maxillo-facial region.

In nearly 90% of lymphatic disseminations, metastasis of carcinomata of the oral cavity follows the normal regional anatomy of the efferent lymphatic system, and usually manifests itself in three homolateral filtering groups. More than 90% of lymphatic metastases occur in the first year following diagnosis of the primary tumour. Such a sequence may be regarded as "regular" metastasis. Anatomical variations and metastasis-induced or therapy-induced blockage of the efferent lymphatic system can change the pattern of metastasis to "irregular". The present studies are specially directed towards recurrence of metastasis, lymphangiosis blastomatosa, the so-called late metastasis as well as the problem of branchiogenic carcinoma. The explanation of clinical aspects has been substantiated with topographic-anatomical and histological findings as well as experience gained in lymphography and lymphoscintigraphy of the cervical lymphatic system.

Carcinoma↗
PubMed1977

Visceral leishmaniasis acquired in Greece: diagnosis and treatment in an American child.

Reported is a case of visceral leishmaniasis acquired in Greece by a 3-year-old American child. Untreated, this protozoan infection causes a high mortality. Specific treatment is available, making early recognition of the illness important. This child's infection responded dramatically to a course of sodium antimony gluconate. Repeat bone marrow cultures demonstrated persistent organisms and a second course of treatment was required. Monitoring of his response to therapy suggested that serial bone marrow cultures and the neutrophil response may be sensitive means for following the course of this infection.

Antimony Sodium Gluconate↗