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Biomedical subjects

H F Seeley

Publications and source records attributed to H F Seeley.

14 recordsLinked to original sources
PubMed1996

The practice of anaesthesia--a stressor for the middle-aged?

Surveys conducted in the United Kingdom over the last few years have revealed decreased job satisfaction and increased anxiety and depression in both hospital specialists and general practitioners. Anaesthesia is perceived to be a stressful specialty and there is evidence, albeit patchy, that certain stress-associated conditions are more common in anaesthetists. The 'middle years' seem to be a danger period. The analogy between the work of anaesthetists and airline pilots is often drawn and the principles underlying the assessment and maintenance of pilot competence could be adopted in anaesthesia. While outcome studies are numerous much less attention has been paid to the structure and process of anaesthetic practice. Models for studying these aspects have been developed for investigating stress in general practitioners and doctors in training. Even minor degrees of professional impairment may place patients at risk and an investigation into the effects of the specialty on those who practise it is justified.

Anesthesiology↗
PubMed1991

Effects of pancuronium and vecuronium on plasma levels of immunoglobulins, IgG, IgM and IgE, in patients undergoing minor gynaecological surgery.

1. The effects of two competitive neuromuscular blocking agents, pancuronium and vecuronium, on plasma levels of immunoglobulins, IgG, IgM and IgE, were studied and compared, using the ELISA assay, in patients undergoing minor gynaecological surgery. 2. The results showed that neither pancuronium (0.1 mg/kg) nor vecuronium (0.1 mg/kg) had any significant effect on IgG, IgM and IgE levels in these patients. However, the underlying trend was that both pancuronium and vecuronium slightly increased the IgG and IgM levels, (by 19.5%, 22.1%, of control IgG, and by 17.3%, 28.8% of control IgM, respectively), with vecuronium being more effective than pancuronium). In addition, pancuronium, but not vecuronium, also slightly increased the IgE levels (by 5.9% of control IgE). Vecuronium, on the other hand, slightly decreased the IgE level (by 4.9% of control IgE). However, these increases or decreases were not statistically significant. 3. The significance of the present results are discussed in relation to changes in immunoglobulins and adverse effects induced by drugs, such as muscle relaxants.

Adult↗
PubMed1987

Assessing blood volume, blood loss and blood replacement.

Blood volume has two components: red cell volume, which can be measured with reasonable precision, and plasma volume, which is more difficult to measure accurately. Measurement of blood loss is discussed with respect to clinical practice and research, and topical issues concerning blood replacement are reviewed.

Blood Transfusion↗
PubMed1987

Pathophysiology of haemorrhagic shock.

Following massive blood loss a number of compensatory mechanisms are activated which are remarkably successful for a limited period. Ultimately the functions of many organs are affected, leading to a vicious circle of impaired cardiac performance and oxygen delivery. The only therapeutic manoeuvre of proven benefit in man is early restoration of circulating volume.

Animals↗
PubMed1986

The Nellcor N-101 pulse oximeter. A clinical evaluation in anaesthesia and intensive care.

The accuracy of the Nellcor N-101 pulse oximeter has been evaluated in adult patients receiving general anaesthesia or intensive care. Readings obtained noninvasively with this instrument were compared with measurements made on arterial blood using a Radiometer OSM2 oximeter. The pulse oximeter was easy to use and within the range tested (70-100 percent saturation of haemoglobin with oxygen) the readings were within I digit of the values obtained by in vitro measurement.

Adult↗
PubMed1978

The clinical management of the aspiration of gastric contents.

The management of the aspiration of gastric contents is considered under five different headings - clearance of the airway, the problem of oxygenation, the use of steroids, the possible use of prophylactic antibiotics and the general measures applicable to the care of any seriously ill patient. An illustrative case report is presented.

Adult↗
PubMed1977

Spontaneous ventilation with the Bain anaesthetic system.

Measurements of ventilation and of inspired gas composition were made while volunteers breathed a non-anaesthetic gas through a Bain anaesthetic system. It was found that rebreathing occurred when the fresh gas flow was between two-and-a-half and three times the minute volume. Fresh gas flows at least three times the minute volume appear to be necessary to prevent rebreathing when using this system.

Anesthesiology↗
PubMed1977

Controlled ventilation with the Mapleson D system A theoretical and experimental study.

A theoretical analysis has been performed to show the interrelationships between alveolar carbon dioxide concentration, carbon dioxide output, alveolar ventilation and fresh gas flow during controlled ventilation with the Mapleson D system. The model and forms of equation used have been substantiated by experiments in which dogs were ventilated through a coaxial version of the Mapleson D system at varying levels of fresh gas flow and alveolar ventilation. By assuming that man ventilated with this system behaves as does the dog, a nomogram has been produced to predict alveolar carbon dioxide concentrations at any levels of fresh gas flow and minute volume.

Anesthesia, Inhalation↗
PubMed1976

The Lack anaesthetic system. An assessment during spontaneous ventilation.

The Lack anaesthetic system is a coaxial modification of the Magill circuit. The resistance of the system was found to be unacceptably high. When air was administered through the system to spontaneously breathing trained volunteers, marked evidence of rebreathing was present when fresh gas flow equalled minute volume. It is suggested that a fresh gas glow equal to one and a half-times minute volume would be required to prevent rebreathing of alveolar gas.

Anesthesia, Inhalation↗