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Biomedical subjects

H F Walker

Publications and source records attributed to H F Walker.

6 recordsLinked to original sources

Comparison of three methods of thiamine supplementation by measurement of urinary thiamine excretion in sheep.

The relative efficacy of thiamine supplementation to sheep by injection, subcutaneous implant and orally administered protected thiamine bolus was compared in two experiments using a grass and hay ration and a ration containing bracken rhizomes to induce thiamine deficiency. In both experiments, urinary excretion of thiamine was significantly higher in supplemented sheep than in the controls, and in sheep supplemented by injection than in sheep supplemented by implant or protected boluses. Thiamine excretion was lower in sheep fed the ration containing bracken rhizomes than in sheep fed the grass ration.

Administration, Oral

The vitamin B6 status of pigs given a diet containing linseed meal.

1. Pigs consuming a diet containing 300 g linseed meal/kg and a pyridoxine supplement showed greater growth, nitrogen retention, blood packed cell volume and haemoglobin than those receiving only the basal diet. 2. Tryptophan-load tests on unsupplemented pigs revealed an increased excretion of kynurenine, Nalpha-acetylkynurenine and xanthurenic acid compared to those receiving additional pyridoxine. 3. The results suggest that the unsupplemented pigs were marginally deficient in vitamin B6. 4. When the same diet was fed to rats there was no evidence of vitamin B6 deficiency.

Animals