Biomedical subjects
Publications and source records attributed to H F Zaglul.
We report on a child with congenital bilateral cervical lung herniation with associated retrosternal (Morgagni), posterolateral (Bochdalek), esophageal hiatal, and inguinal herniae, and with multiple urinary bladder diverticuli. These multiple herniations may be secondary to a defect in the embryonic celomic mesoderm.
OBJECTIVE: To report the occurrence of vesicular lesions on the skin of a child receiving intravenous acyclovir therapy. CASE SUMMARY: A 12-year-old boy with presumed herpes simplex encephalitis developed cutaneous vesicular lesions following intravenous acyclovir administration. The lesions were initially thought to be herpetic. Further evaluation of the vesicle fluid and the temporal relationship of the development of the lesions with acyclovir administration led to the conclusion that the reaction was drug induced. DISCUSSION: Although inflammation and phlebitis are fairly common after acyclovir infusion, the development of vesicular lesions appears to be rare. Only two cases, both in adults, have been published in the medical literature. Although several theories have been proposed, including hypersensitivity, local drug toxicity, and tissue damage associated with extravasation, the mechanism of this reaction remains unclear. CONCLUSIONS: Vesicular eruption is a rare adverse reaction in patients receiving acyclovir. Careful evaluation is necessary to differentiate this reaction from herpetic lesions.
External hydrocephalus (EH) was identified in 58 infants under 3 years of age during the period 1 June 1986 to 28 February 1990. Radiological images and clinical features were compared with 11 cases of cerebral atrophy (CA). Significant differences were found in delivery, head circumference, and the incidence of motor and developmental abnormalities. The population with EH was found to be quite heterogeneous, with a male preponderance. Intracranial pressure was normal in 15 cases in which lumbar puncture was done. The flow of cerebral spinal fluid was considered to be within the normal range in 6 cases. The results of a few cases examined with metrizamide cisternography are presented. The prognosis in our cases was not as benign as previously published, and use of the name EH is questioned. The less committal term "hypodense extracerebral images" is proposed when computed tomography (CT) is the only study done. The hypothesis that encephalocranial disproportion is the basic underlying entity for the CT images is proposed.