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Biomedical subjects

H Fässler

Publications and source records attributed to H Fässler.

6 recordsLinked to original sources
PubMed1978

Assay with chromogenic substrates of in vivo activated proteases.

The proteolytic enzymes of the coagulation and fibrinolysis systems as well as others such as kallikrein, activated under pathological conditions can be determined directly, without manipulations of the plasmas, with the synthetic chromogenic substrates. With these substrates it is possible to follow the protease activity in disseminated intravascular coagulation, during thrombolysis and under other conditions. The lack of absolute substrate specificity makes it imposssible to identify the activated proteases.

Blood Coagulation↗
PubMed1977

[The determination of plasma proteolytic activity].

Experience with different peptide substrates for coagulation and fibrinolysis is reported. As the specifity of these substrates is relative, appropriate characterization of the proteolytic activity of defibrination syndromes is only achieved by simultaneous assays with various substrates. The influence of contact activation on blood sampling must be strictly defined.

Anilides↗
PubMed1977

[The therapeutic scope of oral anticoagulation].

Evaluation of the therapeutic range of oral anticoagulation for different commercial thromboplastins in comparison with Quick's human brain thromboplastin and Thrombotest is based on simultaneous performance of all methods for each blood sample, on strict adherence to the manufacturer's instructions and on adequate statistical analysis.

Blood Coagulation Tests↗
PubMed1976

[Cerebrospinal fluid protein electrophoresis in non-inflammatory central nervous system diseases].

Cerebrospinal fluids (CSF) (N = 365) from patients with non-inflammatory diseases of the central nervous system were analyzed for protein distribution by agar gel microelectrophoresis. After subdivision into diagnostically well defined groups, these patients were compared with 79 normal controls. Most of the diseases investigated were found to follow the "plasma-type" pattern. In some of them the deviations from normal were so extensive that a CSF-protein pattern similar to the "acute-phase reaction" in the serum occurred. Moreover, the following characteristics were found: a considerable increase in total protein and the gamma-globulin fractions in neurinomas; a reproducible increase in the alpha1-globulins in metastases of the central nervous system; and a statistically significant difference of CSF protein findings between male and female patients with protrusion of lumbar intervertebral discs.

Albumins↗