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Biomedical subjects

H Feiner

Publications and source records attributed to H Feiner.

33 records · Page 2Linked to original sources
PubMed1987

Long-term effects of etretinate on the liver in psoriasis.

Etretinate is an aromatic retinoid and derivative of vitamin A soon to be approved for general use in the U.S. as therapy for severe psoriasis. We report on liver morphology and function in 18 subjects who received the drug for at least 5 years as part of a clinical trial. The majority (14) suffered no or mild and reversible structural liver changes; mild transient elevations in serum triglyceride and liver enzymes were noted occasionally. Of the remaining four patients, mild periportal fibrosis was documented in two, another had changes similar to chronic active hepatitis, and a fourth had cirrhosis that was unrelated to alcohol use. Liver function data, cumulative drug dose, and treatment duration were generally not reflective of these changes. The results of this study suggest a need for periodic liver biopsy to monitor patients on long-term etretinate therapy.

Adult↗
PubMed1985

Nephrotoxic serum nephritis with hypertension: amelioration by antihypertensive therapy.

We have examined the effects of antihypertensive therapy on glomerular dynamics and on the clinical and morphologic features of a model of nephrotoxic serum nephritis (NSN) in which hypertension occurs. NSN was induced in uninephrectomized male Sprague Dawley rats, which drank 0.9% sodium chloride ad libitum. One-half were assigned randomly to a treated group whose blood pressure was normalized on a regimen of reserpine, hydralazine, and hydrochlorothiazide. Hypertension continued throughout the 6 weeks of study in untreated rats (blood pressure 148 +/- 5 vs. 103 +/- 3 mm Hg in treated rats, P less than 0.01). Urinary protein excretion was greater (437 +/- 110 vs. 254 +/- 81 mg/24 hr, P less than 0.005), and serum albumin lower (1.6 +/- 0.4 vs. 2.9 +/- 0.3 g/dl, P less than 0.01) in hypertensive animals. Diffuse glomerular endo- and extracapillary proliferation and arteriolar medial hypertrophy were observed frequently in nephritic rats with untreated hypertension. By contrast, structural abnormalities were limited primarily to focal segmental proliferation involving fewer than one-third of glomeruli in the absence of vascular changes in treated normotensive rats. Micropuncture studies performed 8 to 16 days after induction of nephritis showed a reduction in glomerular capillary pressure (46 +/- 1 vs. 55 +/- 1 mm Hg, P less than 0.001), glomerular plasma flow rate (115 +/- 20 vs. 160 +/- 20 nl/min, P less than 0.01), and single nephron filtration rate (42 +/- 4 vs. 56 +/- 5 nl/min, P less than 0.001) with antihypertensive treatment, suggesting that a hemodynamic mechanism may have been responsible for enhanced glomerular injury in the hypertensive nephritic animals.

Animals↗
PubMed1984

Active and chronic phases of Berger's disease (IgA nephropathy).

Berger's disease, or IgA nephropathy, is generally considered as pursuing a chronic course, often with recurrent attacks of gross hematuria or persistent microscopic hematuria. However, little attention has been paid to the acute changes that may accompany this nephropathy, and there are few reports of follow-up renal biopsy studies in these patients. We have had the opportunity to study two patients with Berger's disease (IgA nephropathy) in whom initial and follow-up renal biopsy studies were available. Both of these patients presented clinically with gross hematuria and moderately heavy proteinuria. In both cases, the initial renal biopsy disclosed diffuse mesangial proliferation associated with crescent formation, while follow-up biopsy disclosed only mild mesangial proliferation and no crescents. In one case electron microscopy revealed prominent subendothelial and small mesangial deposits in the initial biopsy, which became almost solely large mesangial in the second biopsy. The other case demonstrated only mesangial deposits in both biopsies.

Acute Disease↗
PubMed1984

Intracardiac leiomyomatosis: diagnosis and treatment.

Intracardiac leiomyomatosis is the presence of a benign smooth muscle tumor within a cardiac chamber reaching the heart by direct intravenous extension from an extracardiac source. After a case report and a review of the 13 previously reported cases, the clinical features, diagnostic considerations, differential diagnosis and treatment modalities of intracardiac leiomyomatosis are discussed.

Adult↗
PubMed1983

Amyloid fibril in hereditary cerebral hemorrhage with amyloidosis (HCHWA) is related to the gastroentero-pancreatic neuroendocrine protein, gamma trace.

Amyloid fibrils were isolated from the leptomeningeal blood vessels obtained at autopsy from three Icelandic patients dying of Hereditary Cerebral Hemorrhage with Amyloidosis (HCHWA) and verified by Congo red staining and electron microscopy. Gel filtration on Sephadex and Ultrogel columns yielded predominantly one component (molecular weight 11,500 daltons) and also another minor component (molecular weight 15,800 daltons). Automated amino terminal sequencing showed these proteins to be similar (36 residues) to a recently described human protein, gamma trace, beginning at its eleventh amino terminal residue. The amyloid deposits in all three patients stained with rabbit anti-gamma trace antiserum. Although the function of gamma trace is not known, it appears to have structural homology with several hormones and has been localized to the brain, pancreas and pituitary. The amyloid fibril subunits seem to have polymerized after cleavage of the amino terminal decapeptide from gamma trace-related proteins. Therefore, HCHWA appears to be the first genetically determined disease related to the gastroenteropancreatic neuroendocrine system.

Adult↗
PubMed1980

Papillary elastofibroma of the left ventricular septum.

Papillary elastofibromas of the heart are usually incidental findings at autopsy. They occur more commonly on the surfaces of the valves than on the mural endothelium and are characterized by a papillary configuration with fronds composed of a collagenous and elastic tissue core lined by hyperplastic endothelial cells. Echocardiography and cardiac catherization demonstrated the lesion preoperatively in this case.

Adult↗
PubMed1978

The role of electron microscopy in the diagnosis of unusual peripheral lung tumors.

The ultrastructure of the lung provides a cytomorphologic basis for the identification of unusual pulmonary neoplasms or unusual histologic variants of more common pulmonary lesions. Comparison of tumor cells with bronchioloalveolar lining cells and with pleural components has aided in the diagnosis of a spindle cell variant of a peripheral neuroendocrine cell tumor (carcinoid) and a tumor composed of cells resembling bronchioloalveolar epithelium (sclerosing hemangioma of lung).

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMed1978

Electron microscopy of neoplasms of pancreatic islet cells.

Neoplasms of pancreatic islet cells that produce widely divergent clinical syndromes cannot be distinguished from one another by conventional microscopy. Differentiation among these tumors by electron microscopy is possible in some cases only. Coordinated clinical evaluation, histochemical and ultrastructural studies, and assay of serum and neoplastic tissue for various polypeptide hormones afford the best characterization of these neoplasms.

Adenoma, Islet Cell↗
PubMed1977

Ultrastructure in glomerulonephritis associated with cryoglobulinemia. A report of six cases and review of the literature.

Renal tissue from 6 patients with glomerulonephritis associated with cryoglobulinemia was studied by light microscopy, immunofluorescence microscopy, and electron microscopy. Fibrillar deposits in glomerular capillaries were observed in electron micrographs in 4 of 6 patients. The ultrastructure of these deposits is compared with those in 6 previously reported cases, with the ultrastructure of the serum cryoprecipitates, and with fibrillar glomerular deposits in other glomerulonephritides. It is concluded that serum cryoprecipitates are structurally similar to glomerular deposits and that these fibrillar deposits are a frequent and possibly distinguishing morphologic feature of glomerulonephritis associated with cryoglobulinemia.

Adult↗
PubMed1976

Pancreatitis after cardiac surgery; a morphologic study.

Acute pancreatitis is a well known occurrence after upper gastrointestinal and biliary tract surgery when local trauma plays a major role in the pathogenesis of this complication. The incidence of pancreatitis after surgical procedures during which local trauma to the pancreas does not occur is extremely low (less than 0.1%). In the present study the incidence of unexplained pancreatitis in 182 patients who died after cardiac surgery was 16%. The role of ischemia in the pathogenesis of pancreatitis in this setting is evaluated.

Cardiac Surgical Procedures↗
PubMed1976

Ultrastructural evidence of myofibroblasts in circumscribed fibromatosis.

The myofibroblast, which exhibits ultrastructural features of both smooth muscle cells and fibroblasts, is the predominant cell type in the granulation tissue of healing wounds. Similar cells were identified in an ultrastructural study of a case of circumscribed fibromatosis. Myofibroblasts have been described in several apparently unrelated conditions, suggesting that the acquisition of smooth muscle-like features is one of a limited number of ways in which fibroblasts may react to abnormal stimuli.

Adult↗