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Biomedical subjects

H Feldner

Publications and source records attributed to H Feldner.

14 recordsLinked to original sources
PubMed1994

Sensitization to storage mites in house dust mite (Dermatophagoides pteronyssinus) allergic patients. Comparison of a rural and an urban population.

In this study, sera collected from 50 patients (24 females, 26 males) with Type I allergy to house dust mite (Dermatophagoides pteronyssinus) were investigated for IgE antibodies specific for eight different mite species including storage mites of the families Pyroglyphidae, Glycyphagidae and Acaridae. According to their environment the patients were divided into two groups. Group I consisted of 24 (11 women, 13 men) farmers working and living in rural regions of Austria (Styria, Lower Austria), group II included 26 citizens of Vienna (13 women, 13 men). As expected, RAST investigations revealed a higher rate of sensitization to storage mites in the farmer group. Comparing the two patient groups, sensitization to Lepidoglyphus destructor and Tyrophagus putreus was markedly increased in the farmer group. However, the sensitization rate to storage mites was also considerably high in city dwellers. Elevated levels of IgE specific for Euroglyphus maynei were more frequently observed in the urban collective. RAST-inhibition experiments suggest a partial crossreactivity between house dust mites and storage mites. In their living environment, patients with perennial Type I allergy are exposed to multiple different mite-derived allergens in addition to the well-known house dust mite allergens. These allergens lead to sensitization and are therefore of clinical importance.

Allergens↗
PubMed1989

Characterization of Micropolyspora faeni antigens by human antibodies and immunoblot analysis.

IgG, IgM and IgA antibody responses against Micropolyspora faeni (Mf) antigens were studied by means of immunoblotting experiments using 70 sera derived from three groups of farmers, namely patients with extrinsic allergic alveolitis (EAA) due to thermophilic actinomycetes (n = 25), patients without EAA but with hay exposure (n = 14), and patients suspected to have EAA (n = 31), and 27 sera from two groups of control persons (healthy laboratory workers, n = 13; healthy farmers, n = 14). Patients with EAA showed IgG, IgM and IgA antibody responses mainly against the antigens with molecular weights (MW) of 11, 12, 25, 35 and 60 kD ("major antigens"), and in addition, but less often, against six antigens with MW in the range of 15 to 62.5 kD ("minor antigens"). The other two groups of patients and also the exposed control persons showed very similar results; however, the antibody response in healthy farmers was substantially weaker in comparison to the three groups of patients and was almost limited to the major antigens with MW 11, 25 and 60 kD. Although patients with proven EAA had higher amounts of antibodies, there was no correlation between this antibody response and the onset of disease. The results indicate the necessity of including at least the major antigens with MW of 11, 25 and 60 kD in all extracts used for in vitro diagnosis of Mf-induced EAA.

Adult↗
PubMed1986

[Health management--physical therapy in chronic nonspecific airway diseases. Prevention and rehabilitation].

First of all there is a description of the temporal change of a cure at a spa to a modern treatment for rehabilitation. Today treatments for rehabilitation are methods treating COLD in addition to medical care of a general practitioner or a specialist and the function of a hospital in acute and severe diseases the third practicability of treatment. Treatment in a sanatorium is preferred by social assurances. Diagnostic management and physical treatment, physical training and education in health represent an extensive medicine program. The cooperation of sanatorium of medicine rehabilitation with social workers for professional rehabilitation guarantees a transition from medical to professional rehabilitation, with the purpose to achieve an improvement for patients with bronchopulmonal handicaps in their social and professional situation.

Airway Obstruction↗
PubMed1983

[Extrinsic allergic alveolitis: comparison of 2 methods (Ouchterlony gel precipitation and ELISA) for antibody detection in routine diagnosis].

Sera from 58 patients with suspected extrinsic allergic alveolitis (EAA) were tested in parallel by the double diffusion test and the "enzyme-linked immunosorbent assay (ELISA)" using 10 different antigen solutions (extracts from thermophilic actinomycetes, various mycetes, pigeon serum, pigeon droppings and the wheat weevil sitophilus granarius). The ELISA technique was more sensitive than the double diffusion test in detecting antibodies to the panel of antigens used. However, by using several antigen dilutions the number of sera positive sera with the double diffusion test increased and an overall correlation of 93.1% with the ELISA was achieved. The results of the study are discussed with regard to the advantages and disadvantages of both test systems for the in vitro diagnosis of EAA.

Adult↗
PubMed1981

[Some observations on farmer's lung (author's transl)].

Sera from 72 patients--29 females, 43 males--with symptoms suggestive of farmer's lung were tested by the Ouchterlony double diffusion technique using 10 different antigen solutions (extracts from mycetes and thermophilic actinomycetes, pigeon serum, extracts from pigeon droppings and Sitophilus granarius). In 23 cases precipitating antibodies were observed and Micropolyspora faeni was the most common antigen responsible for positive reactions. In 17 seropositive patients the diagnosis of exogen allergic alveolitis was established by clinical and laboratory findings. Measurements of immunoglobulins in these sera showed pronounced elevation of IgG and slightly elevated levels of IgA; IgM, IgE and C 3 c levels were in the normal range. The results are discussed with regard to the classification of farmer's lung as an occupational disease in Austria since December 30th, 1980.

Complement C3↗