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Biomedical subjects

H Fernández

Publications and source records attributed to H Fernández.

At least 19 recordsLinked to original sources
PubMed1992

[Test with vasoactive drugs: its predictive value in the diagnosis of erectile sexual dysfunction of venous origin].

The practicability and sensitivity of the test with vasoactive drugs, the first method performed in our flow studies, make it an invaluable method for orienting the diagnosis. Our findings show that in 65% of the patients with a partial response to the drug-induced erectile test, dysfunction may arise from pure or associated venous leakage, which must be confirmed by dynamic cavernosometry and/or cavernosography.

Adult↗
PubMed1991

Benzodiazepine receptor ligands and sexual behavior in the male rat: the role of GABAergic mechanisms.

Diazepam and chlordiazepoxide produced a dose-dependent inhibition of ambulatory activity, motor execution and sexual behavior. The benzodiazepine antagonist flumazenil had no effect on these behaviors, while the inverse agonist FG 7142 inhibited sexual behavior without affecting motor functions. The GABA antagonist bicuculline was ineffective in all behavioral paradigms, while picrotoxin inhibited all behaviours. Picrotoxin blocked the motor effects of low doses of the benzodiazepines, but not those of higher doses. Neither did this drug block the effects of benzodiazepines on sexual behavior. Bicuculline was unable to block the effects of benzodiazepines on all behaviors. FG 7142, in a low dose, inhibited the effects of diazepam and chlordiazepoxide on ambulatory activity, but not their effects on motor execution or sexual behavior. The effects of the benzodiazepines and picrotoxin on sexual behavior could be a consequence of the motor impairment produced by these drugs, since the doses required to affect these two behaviors were similar. However, the fact that picrotoxin could block the motor deficiencies induced by the benzodiazepines without restoring sexual behavior suggests that these behavioral actions of the drugs can be differentiated. While some evidence was obtained suggesting a role of GABA in the motor effects of benzodiazepines, no evidence could be found for a role of GABA in their effects on sexual behavior.

Animals↗
PubMed1991

Campylobacter intestinal carriage among stray and pet dogs.

The natural distribution of thermotolerant Campylobacter sp. in dogs (150 stray animals and 64 pets) was studied. Campylobacters were more frequently isolated (p < 0.01) from stray dogs (51.3%) rather than from pet dogs (21.9%). All the biotypes described by Lior for C. jejuni and C. coli were found among stray animals, whereas only C. jejuni biotypes I and II and C. coli biotype II were found among pet dogs. The need for more studies related to the role of environmental sanitary conditions in the spreading of Campylobacter species is noted.

Animals↗
PubMed1990

Effect of chronic administration of verapamil in Duchenne muscular dystrophy.

1. In DMD patients the effect of chronic treatment with verapamil was investigated in the p-nitrophenylphosphatase from erythrocytes, the CK and LDH in serum and the functional activity of the muscle. 2. A different behaviour in the p-nitrophenylphosphatase from untreated compared to treated DMD patients and controls is supported by the following findings: (a) values of "n" altered in F- inhibition of the enzyme with Hill coefficients -1.43, -2.18 and -2.19; (b) Arrhenius plots between 16 and 40 degrees C with inflection points for the enzyme from treated DMD patients and controls and not from untreated DMD patients. 3. Although CK and LDH in serum and the muscular evaluation showed no statistical difference between both groups, evidence is presented that in treated DMD patients the interaction membrane-enzyme is different from untreated DMD patients.

4-Nitrophenylphosphatase↗
PubMed1989

Dopamine and sexual behavior in the male rat: a reevaluation.

In castrated male rats treated with a low dose of testosterone propionate (0.40 mg/kg per week), the dopamine agonists amphetamine and amfonelic acid reduced mount latency without affecting other aspects of sexual behavior. Apomorphine, in doses between 0.05 and 0.15 mg/kg, and 1-DOPA 5-45 mg/kg + carbidopa 50 mg/kg, lacked effect on sexual behavior. Both amphetamine and amfonelic acid increased locomotor activity in a dose-dependent manner. Apomorphine, in the lowest dose, produced a reduction whereas the higher doses of this drug as well as all doses of 1-DOPA lacked effect on this behavior. In castrated animals implanted with a testosterone-filled Silastic capsule, showing a level of sexual activity indistinguishable from that of intact animals, amphetamine and amfonelic acid did not affect sexual behavior. The dopamine receptor antagonists haloperidol and cis(Z)-flupentixol reduced sexual behavior, whereas pimozide was without effect in the dose range used. The doses of haloperidol and flupentixol that were required to reduce sexual activity were such that they also affected motor execution measured in a treadmill test. It is suggested that increased dopaminergic neurotransmission may stimulate sexual behavior in an indirect way, augmenting behavioral arousal. The inhibitory effects of dopamine antagonists could be explained either by a reduced arousal level or by motor deficiencies.

Amphetamines↗
PubMed1989

Relationships between the Goodenough-Harris Draw-a-Person Test and a body-image test in Costa Rican children.

Although researchers have used drawings of the human figure to evaluate body-image in adults and children, test measures of the concepts involved have not been precisely constructed, so the purpose of this study was to estimate the body-image concept relations measured on the Goodenough-Harris Draw-a-Person Test and on the Prueba para Diagnóstico de Imagen Corporal--Universidad Nacional for 90 kindergarten, first and second graders. Factor analyses (sex by grade, 2 x 3; and sex by age, 2 x 7) showed that sex was not a significant factor on either measure, but grade and age were. A Pearson correlation for the total scores on both tests was a moderate, significant value of .45. Correlations of the total with subtest scores varied from .30 to .50. Values were strongest for first grade children from 6 to 6 1/2 yr. of age (.59 to .78), at the beginning of the developmental period in which children gradually gain an awareness of the parts of the body, their functions and left-right concepts.

Art↗
PubMed1989

[Is it useful to ask questions to assess the strength of urination flow?].

In order to determine the value of the interview conducted to assess the micturitional stream of our patients, we compared in 200 cases what the patients said about their micturition against their maximum flow rate (QMx). We demonstrated that 79% of those who said they voided with a "bad stream" had QMx less than or equal to 10 ml/sec. Only 65% of those who said they voided with a "good stream" had a QMx less than or equal to 15 ml/sec. Of those with QMx less than or equal to 10 ml/sec. (73 patients), only 15% had reported a "bad stream". Thus, we believe it is not reliable and of little interest to ask our patients about the strength of their micturitional stream. It would only be useful in those who reported a "bad voiding". To our knowledge, this is the first study that documents the discrepancy between data from the interview and the maximum flow rate.

Adolescent↗
PubMed1988

Allosteric transition of erythrocyte alkaline phosphatase from Duchenne muscular dystrophy (DMD) patients and Duchenne muscular dystrophy carriers (Homo sapiens).

1. The kinetic properties of the p-nitrophenylphosphatase (EC 3.1.3.1) from erythrocytes was investigated in DMD-patients and DMD-carriers. 2. A different allosteric behaviour in the p-nitrophenylphosphatase from DMD-patients and DMD-carriers compared to controls is supported by the following findings: (a) values of n altered in F- inhibition of (K+)-activated p-nitrophenylphosphatase with Hill coefficients -1.5, -2.2 and -3.1; (b) heterotropic effect of increased concentration of Mg2+ on F- inhibition which is reverted by K+ in DMD-carriers and in control, but not in DMD-patients. 3. Evidence is presented showing that in DMD-patients and in DMD-carriers the interaction membrane-enzyme is different from the corresponding controls.

4-Nitrophenylphosphatase↗
PubMed1987

4-Nitrophenylalkaline phosphatase inhibition in muscular dystrophy.

The allosteric behaviour of 4-nitrophenylphosphatase from membrane erythrocytes was investigated in Duchenne muscular dystrophy (DMD) patients, in female carriers and in healthy controls. Cooperative type kinetics with a Hill coefficient of -2.19, -1.71 and -1.54 has been obtained from the inhibition by fluoride in controls, female carriers and Duchenne patients, respectively. Our observation supports the previously described membrane abnormalities in DMD erythrocytes and may extend then to female carriers.

4-Nitrophenylphosphatase↗
PubMed1987

Differential effects of GABA transaminase inhibitors on sexual behavior, locomotor activity, and motor execution in the male rat.

The GABA transaminase inhibitors gamma-acetylen GABA (GAG) and sodium valproate were administered intraperitoneally and their effects on locomotor activity, motor execution and sexual behavior were analyzed. It was found that sodium valproate, administered 15 min before observation, reduced locomotor activity only at a dose of 200 mg/kg. Doses of 100 and 400 mg/kg had no effect. Motor execution was impaired in a dose-dependent way, the lowest effective dose being 200 mg/kg. Sexual behavior was also dose-dependently reduced. Sodium valproate, administered 60 min before observation, inhibited all behaviors. The lowest effective dose was 200 mg/kg for locomotor activity and 400 mg/kg for motor execution and sexual behavior. GAG also inhibited all behavior, in doses ranging from 25 mg/kg (locomotor activity) to 100 mg/kg (motor execution and sexual behavior). The data showed that there is no relation between effects on locomotor activity and the effects on sexual behavior, whereas sexual behavior is inhibited whenever motor execution is impaired. Moreover, there is no correlation between effects on locomotor activity and motor execution. It is suggested that GABA transaminase inhibitors effect sexual behavior only indirectly, via an impairment of motor execution. Therefore it is doubtful whether GABAergic mechanisms play any role in the normal regulation of sexual behavior.

4-Aminobutyrate Transaminase↗