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Biomedical subjects

H Ferrari

Publications and source records attributed to H Ferrari.

13 recordsLinked to original sources
PubMed2004

Myelopathy with syringomyelia following thoracic epidural anaesthesia.

Under general anaesthesia and muscle relaxation, a thoracic epidural catheter was inserted at the T8-T9 level in a 7-year-old boy scheduled to have a Nissen fundoplication to provide postoperative analgesia. After 4 ml of lignocaine 1.5% was injected through the catheter, hypotension resulted. Fifty-five minutes later 5 ml of bupivacaine 0.25% produced the same effect. In the recovery room a similar injection resulted in lower blood pressure and temporary apnoea. Sensory and motor deficits were noted the next day and four days later magnetic resonance imaging demonstrated spinal cord syringomyelia extending from T5 to T10. Four years later, dysaesthesia from T6 to T10 weakness of the left lower extremity and bladder and bowel dysfunction persist. The risks of inserting thoracic epidural catheters in patients under general anaesthesia and muscle relaxation are discussed, emphasising the possibility of spinal cord injury with disastrous consequences.

Anesthesia, Epidural↗
PubMed1989

[In vitro action spectrum of a new antifungal agent derived from morpholine: amorolfin].

The minimal inhibitory concentrations of amorolfin against yeasts, dermatophytes, Sporothrix schenckii and moduls were determined on Sabouraud's dextrose agar by dilution test procedure (Dixon's agar for Malassezia). The yeasts (Candida, Torulopsis, Trichosporon) present various susceptibility, MIC ranged from 0.01 to 1 micrograms/ml-1 for sensible strains particularly Malassezia (0.005-0.5 microgram/ml-1) ranged from 20 to 100 micrograms/ml-1 for resistant isolates. Amorolfine is also effective on Sporothrix schenckii (0.5 microgram/ml-1) Scopulariopsis brevicaulis (0.2-5 micrograms/ml-1) but with Aspergillus and Fusarium higher concentrations (10-100 micrograms/ml-1) are necessary. Dermatophytes are largely susceptible to amorolfine (MIC ranged to 0.005 to 0.2 microgram/ml-1) whatever the tested species were belonging to Microsporum, Trichophyton or Epidermophyton. So, amorolfine seems to be a very effective antifungal agent against those pathogenic fungi.

Antifungal Agents↗
PubMed1986

[In vitro spectrum of action of a new antifungal derivative of naftifin: terbinafin (SF 86-327)].

Terbinafine (SF 86-327) is a new antifungal agent derived from naftifine and effective by the oral route. We studied the in vitro antifungal activity of terbinafine (SF 86-327) against several pathogenic fungi responsible for human disease. Tested pathogens included yeasts (Candida), dermatophytes (Microsporum, Trichophyton, Epidermophyton), molds (Aspergillus, Scopulariopsis) and dimorphic fungi (Sporothrix schenkii). Broth dilution (Sabouraud) or agar dilution (Sabouraud, Kimmig) were used. 322 strains of pathogenic fungi belonging to 23 different species were tested. The yeasts showed varying degrees of susceptibility (MICs ranging from 10 to 100 micrograms/ml) except for Candida parapsilosis (MICs 1 to 2 micrograms/ml). Strong susceptibility was found for molds (MICs 0.1 to 2 micrograms/ml), especially Scopulariopsis brevicaulis and Sporothrix schenkii (MICs 0.2 microgram/ml). Dermatophytes were also highly susceptible to terbinafine (MICs 0.001 to 0.02 microgram/ml).

Antifungal Agents↗
PubMed1985

[In vitro action of a new antifungal agent, naftifine, on dermatophytes].

Naftifine is a new antifungal agent derived from naphtalenemethane amine and highly active in vitro against dermatophytes. We studied this action against more than 100 strains belonging to 16 different species of the Trichophyton, Microsporum and Epidermophyton genera. MICs were determined in a liquid or solid medium using YMA and YMB Sabouraud broths. Yeasts (Candida, Torulopsis) and certain molds such as Scopulariopsis brevicaulis showed little susceptibility. In contrast, MICs for dermatophytes ranged from 0.01 to 0.2 microgram/ml on agar (YMA Sabouraud) and from 0.2 to 2 microgram/ml in broth (YMB Sabouraud). These values are lower than those obtained under similar conditions with imidazoles and equivalent to those obtained with tolnaflate or griseofulvin.

Allylamine↗
PubMed1983

[Medico-psychological interconsultation and the physician-patient relation].

Clinicians and psychoanalysts have been working together sharing responsibilities for the clinical care of patients with somatic illness. This has opened a new field for interdisciplinary action, the so-called Medical Psychological consultation (MPC). The MPC is the application of psychoanalytic understanding to this new field. In the present paper, the medical setting and the analytic setting are defined and clearly distinguished. The most significant goal in MPC is to assist or help in the assistance or care of the patients. To attain a good standard of clinical care means to provide a highly personalized help to a patient based on an adequate discrimination of his physical and emotional needs. The MPC is a new scientific development that works on that direction.

Humans↗
PubMed1976

[Medical discharge from a hospital].

Admission and discharge procedures are prominent aspects in the assistential care of hospitalized patients. A great deal of attention has been paid to the reasons why they stay overtime when they apparently are ready for discharge. Lab routine delays and other technical difficulties have been traditionally blamed for failing to operate on schedule. However, even when studies are completed and diagnosis and treatment performed, the patient still remains overtime. This paper presents a research on discharge from a medical ward of a general hospital. According to rules, they were not supposed to stay more than two weeks, time enough for usual diagnostic and therapeutic procedures. However, 18 out of 121 patients were exceeding the limit and were subject to the present investigation. The Medical-Psychological Interconsult was the research instrument. The patient, the family, the doctor and the nurses were interviewed in each case. In every one of the 18 cases, problems were found in the doctor-patient relationship, as well as other difficulties in different institutional levels. The value of a multidisciplinary approach in problems of this kind is emphatically stated (clinicians, psychologists and medical auditors).

Adult↗
PubMedDate not supplied

Surgical treatment of giant left ventricular aneurysms. The intraventricular resection technique.

The intraventricular resection technique for giant aneurysm of the left ventricle decreases anoxic cardiac arrest time and controls the detachment of intramural thrombus. To perform this technique, it is necessary to expose only a longitudinal segment on the anterior aspect of the aneurysm to permit a ventriculotomy parallel to the anterior descending coronary artery 4-5 cm away. In the same way, to resect a giant aneurysm of the diaphragmatic aspect, only a segment parallel to the posterior descending coronary artery needs to be exposed. Then with the clear intraventricular vision of the limit between the fibrous sac and the contracting left ventricle, the surgeon rapidly detaches the aneurysm. In any case besides the relation of this limit, the transecting line must keep away at least 4 cm from the implantation of the papillary muscle of the mitral valve, in order to leave an adequate functional chamber for the left ventricle. The early visualization of the mitral apparatus during the resection of giant aneurysm is another basic advantage of the intraventricular approach. The ventriculotomy is closed with a running suture and coronary circulation is restored. Anoxic cardiac arrest averaged 15 minutes in the five out of six cases of giant aneurysm treated with this technique. In the period July 1972-December 1973, 28 aneurysms of the left ventricle with varied associated pathology have been treated in this surgical unit, with 14% (4 cases) mortality. By contrast, no death has been registered in this severely ill group of six patients with giant left ventricular aneurysm. In cases I and VI myocardial revascularization was added. Two important aspects contribute to the excellent long term result in this group. 1. Correction of the altered geometry and consequent dysfunction of the left ventricle. 2. Correction of the functional ischemia of the contracting myocardium. The presence of giant aneurysm increases the left ventricle wall tension, including the contracting mass, and consequently the myocardial oxygen consumption.

Aged↗