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H Finger

Publications and source records attributed to H Finger.

At least 73 records · Page 4Linked to original sources
PubMed1976

[Studies on the mechanism and duration of antibody-mediated immunosuppression (author's transl)].

The simultaneous injection of either 10(8) or 5 X 10(5) sheep erythrocytes (SE) and an allogeneic anti-SE serum into mice produced not only a suppression of the primary immune response, but, moreover, the secondary immune reaction elicited, either 4, 8, 12, 16 or 30 weeks after the primary antigenic stimulation, was found to be impaired. This was mainly demonstrated by the significantly reduced numbers of 7 S antibody-synthesizing spleen cells. The suppression of the secondary immune responses is hardly compatible with the conception that the antibody-mediated immunosuppression is solely due to an inactivation of the antigenic determinants by the passively administered specific antibody in the periphery of the immune system. This objection against the so-called "peripheric theory" is supported by a further finding. When mice primarily immunized by a simultaneous injection of 10(8) SE and anti-SE-serum were treated with 2 X 10(7) SE 24 hours before boostering with 10(8) SE, in order to eliminate a possibly existing residual activity of the passively administered specific antibodies given together with the primary antigenic stimulus, the secondary 7 S response was likewise found to be significantly suppressed. On the basis of these findings it is suggested that besides the "peripheric mechanism" a "central" effect plays a significant role in the phenomenon of antibody-mediated immunosuppression, this being due to the reversible or irreversible inactivation of immunocompetent precursor cells by the attachment of antigen-antibody-complexes which results in an inhibition of their differentiation into antibody-producing cells.

Animals↗
PubMed1975

Listeria monocytogenes infection in nude mice.

As compared to phenotypically normal (nu/+)NMRI mice showing the typical course of an experimental listeric infection, that of congenitally hypothymic (nude, nu/nu)NMRI mice was found to be characterized from the outset bya chronic trend. During the early phase of the infection, significantly reduced numbers of Listeria monocytogenes were observed in the spleens of nude mice.

Animals↗
PubMed1975

Studies on the immunizing capacity of orally administered particulate antigens. II. Production of immunological memory in germ-free mice by orally administered sheep erythrocytes.

A study was perfromed to find out, whether or not the oral administration of sheep erythrocytes results in a general primary immune reaction as well as in effective priming for the secondary response in both conventional and germ-free NMRI mice. Whereas negative results were obtained with conventionally held mice, five oral applications of 0.3 ml of a 60% suspension of sheep erythrocytes to germ-free mice, each dose separated by an interval of 24 hr, resulted in a general primary immune response both at the cellular and humoral levels. When such pretreated mice were given an i.p. injection of 4 times 10(8) sheep erythrocytes as a secondary antigenic stimulus 32 days after the last of the five oral applications, the subsequent response was characterized by the predominant development of 7S hemolysin-producing spleen cells. This evidently indicates that effective priming for the secondary response has taken place by the orally administered antigen.

Administration, Oral↗
PubMed1975

[Tetanus immunity during senescence (author's transl)].

The circulating concentrations of antibodies directed against tetanus toxoid were determined by means of the mouse protection test in the serum samples of 2554 patients with an age between 60 and 98 years. Additionally, a part of the sera was tested by a radioimmunologic procedure. Immunity (neutralizing antitoxin titer greater than or equal to 0.01 International Units/ml serum) was only demonstrable in a small percent of the samples (15.3%). Compared to women, a larger percentage of men were found to be protected. Active immunization of aged persons (60-93 years old) resulted in the finding that usually also during senescence powerful immunity may develop following suitable vaccination.

Aged↗
PubMed1975

Adjuvancy of streptococcal nucleic acids.

A study was performed to find out whether or not RNA and DNA isolated from Group A streptococcal cytoplasm does possess adjuvant activity. The findings obtained indicate that the adjuvancy of streptococcal RNA is very similar to that of poly I:C. The adjuvant activity of poly I:C is characterized by its capacity to increase the number of pre-existing hemolysin-producing spleen cells and by its ability to increase the development of 19S and 7S producers early in the 12-day-period of primary immune response. The adjuvancy of streptococcal DNA was considerably less pronounced than that of RNA. Neither poly I:C nor streptococcal RNA and DNA were found to be capable of increasing the process of priming for the secondary immune response.

Adjuvants, Immunologic↗
PubMed1975

Studies on the immunizing capacity of orally administered particulate antigens. I. The efficiency of killed Bordetella pertussis cells.

The single i.p. injection of 2.5 times 10-8 killed B. pertussis cells protected 23 out of a group of 24 NMRI mice (95.8%) against the subsequent intracerebral infection, whilst 13 out of 24 mice (54.2%) survived the intracerebral challenge with virulent B. pertussis cells after prior oral administration of 2.5 times 10-11 killed B. pertussis cells, as demonstrated by the mouse protection test. Similar treatment with non-specific substances, such as egg white and saline, did not result in any increase of resistance. Systemic anaphylactic hypersensitivity to bovine serum albumin could also be achieved, when either both the protein antigen and the B. pertussis vaccine were given by the oral route or when the B. pertussis vaccine was injected intraperitoneally into mice which had received the soluble protein antigen by the oral route. Such effects were not produced at all in the reverse situation, when the B. pertussis vaccine was orally administered in mice, which were given the soluble protein antigen by the intraperitoneal route. After oral inoculation of 6 times 10-11 killed B. pertussis cells neither splenomegaly nor blood lymphocytosis became detectable. It is still unknown, in which manner the orally administered B. pertussis vaccine effects protection against the intracerebral infection with virulent bacteria as well as susceptibility for systemic anaphylaxis. The data presented do not favor the view that those effects are due to the phenomenon of persorption.

Administration, Oral↗
PubMed1975

Influence of Bordetella pertussis and bacterial endotoxins on the immunological reactivity of germfree mice.

As compared to specifically pathogen-free NMRI mice, in principle, the immunological reactivity of germfree mice of the same strain and age was not found to be reduced. This is documented by the cellular kinetics of the primary immune responses, evoked by the intraperitoneal (i.p.) injection of either a "saturated" dose of 4 times 10(8) sheep erythrocytes (SE) or the simultaneous injection of 4 times 10(8) SE and 3 times 10(9) killed Bordetella pertussis organisms (PO). Thereby, adjuvancy of PO was not found to be reduced in germfree mice. The only difference consisted in the demonstration of significantly reduced numbers of both direct and indirect plaque-forming spleen cells (PFC) on the 4th day after primary antigenic stimulation. This is suggested to be due to a lack of sufficient training of the immunological apparatus of germfree mice. Both in germfree and conventional mice significant splenomegaly, blood leukocytosis as well as increase in the numbers of pre-existing "background" PFC became detectable following a single i.p. injection of 3 times 10(9) PO without SE. Similarly, the injection of endotoxin from Serratia marcescens produced a moderate increase in the numbers of "background" PFC. From the data presented it is suggested that strict gnotobiotic conditions do not cause noteworthy deficiency in immunological competence.

Adjuvants, Immunologic↗
PubMed1975

[Immunosuppression mediated by antibodies (author's transl)].

Until quite recently, it was generally believed that antibody-mediated immunosuppression is purely effected by virtue of covering up antigenic determinants in the periphery of the immune system, thus preventing any contact of the antigen with immunologically competent cells within the central parts of the immune system. But this conception was not able to give a plausible explanation of experimental data obtained during the last years. It was therefore repeatedly postulated that the passively administered 7S antibody may have a "central" effect, whereby both B- and T-cells were considered as target cells. The experimental data available are discussed in connection with the possible consequences for the administration of antibodies in man.

Adjuvants, Immunologic↗