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Biomedical subjects

H Fischer

Publications and source records attributed to H Fischer.

At least 19 recordsLinked to original sources
PubMed1979

[Serum activity of leucine aminopeptidase in lymphotropic infections and in malignant lymphomas].

Increases of the leucine aminopeptidase according to data of literature are regarded as a sensitive parameter of lesions in liver diseases. In patients with active generalised lymphadenitis (viral infections, toxoplasmosis) as a typical enzyme constellation a relatively strong leucine aminopeptidase increase in the serum with missing or relatively slight enzyme deviation of the transaminases could be found. The quotient of the activities of LAP/ALAT was clearly above that of inflammatory liver diseases. In chronic lymphatic leukosis, plasmocytoma and malignant lymphomas the leucine aminopeptidase serum activities were within the normal. Increases of leucine aminopeptidase in lymphotropic infections are probably partly of extrahepatic origin.

Humans↗
PubMed1979

[Gunshot wounds by military weapons].

The review is based on 34 recent publications. Bullet-wounds by military weapons either in drill or war are to be regarded as special kinds of wounds, needing profound knowledge of wound ballistic. However, the therapy of late developing complications may lead to problems.

Anesthesia, Local↗
PubMed1979

[Gunshot wounds in peace and their treatment. Review of the literature].

For therapy of bullet-wounds in peace profound knowledge of their pathogenesis is necessary. This may be especially true for wounds evoked by new developed weapons. It may be assumed that often therapists are not familiar with the effects of these modern weapons. This review of 27 international publications therefore represents particularities of wounds of the body cavities and the extremities. Furthermore the problem of bulletembolies is represented.

Abdominal Injuries↗
PubMed1979

Effects of angiotensin II and angiotensin II antagonist saralasin on cell growth and renin in 3T3 and SV3T3 cells.

Components of the renin-angiotensin system were studied in established cell culture lines of 3T3 and SV3T3 mouse fibroblasts. The renin content in 3T3 cells was significantly higher than in virus-transformed SV3T3 cells. With time after infection, renin decreased in Simian virus 40 transformed cells, while it increased steadily in mock-infected 3T3 cells. In contrast to renin, angiotensinase activity was higher in SV3T3 cells. Angiotensin II stimulated cell proliferation in 3T3 mouse fibroblasts and decreased their renin content in a dose-related manner. In contrast, saralasin, an angiotensin receptor antagonist, inhibited cell growth in 3T3 and SV3T3 cells and caused an increase of cellular renin concentration. The angiotensin fragments angiotensin (2-8) heptapeptide and angiotensin (4-8) pentapeptide had no effect on cell growth. A significant negative correlation was found between cell proliferation and renin levels in 3T3 and SV3T3 cells irrespective of the treatment. Our results indicate (1) that angiotensin II may be involved in cell growth regulation, (2) that a negative feedback exist between angiotensin II added and intracellular renin content, and (3) that virus infection causes a decrease in intracellular renin synthesis, while non-specific angiotensinase activity is increased under this condition.

Angiotensin II↗
PubMed1979

Sclerosing angioma of the lung. Case report and electron microscope investigation.

Electron microscopy of a sclerosing angioma of the lung, a coincidental finding in the upper lobe of a 32-year-old woman. The rare, benign tumor, whose vascular proliferation by light microscopy is reminiscent of an angioma, exhibits a clear epithelial structure by electron microscopy. The tumor may develop out of immature pneumocytes. The paper discusses histogenesis and problems of differential diagnosis (potential confusion with carcinomas).

Adult↗
PubMed1979

SV40-related T-antigen expression in human meningiomas with normal and G-22-monosomic karyotype.

Six of 16 meningiomas tested in early subcultures by indirect immunofluorescence showed SV40 T-antigen. Two different antisera specific for T-antigen were used. One serum gave a positive reaction with six tumours and the other with only two. In one T-antigen positive meningioma, the typical nuclear fluorescence changed, beginning with the second subculture, into an unusual brilliant granular pattern irregularly distributed over the nuclei. In six meningiomas, a specific chromosome aberration (monosomy G 22) was established. However, up to now, no clear correlation between karyotype and T-antigen expression could be found: cells from three meningiomas with positive reactions had normal karyotypes, whereas those from three tumours with typical chromosome loss showed no T-antigen.

Antigens, Neoplasm↗
PubMed1979

[A method of suture-free anastomosis of nerve transplantation is being reported, using facial nerve as the example (author's transl)].

After microsurgery preparation, the endings of the nerve trunk, which have been freed from epineurium, are approxiamated on top of a gelatin platelet (gel foam) which has been soaked in a nutrient solution. The gelatin platet is then formed like a tube and wrapped around the ends of the anastomosis. Using this procedure, suture-induced reactions in the vicinity of the anastomosis are prevented. The connection is sufficiently firm so as to withstand tension incurred in chewing and in movement of the head. Additionally, the gelatin coating prevents early onset of fibrosis, which as a process is normally induced by the surrounding tissues onto transplants. Simultaneously, nutrition of the transplant is guaranteed during the first post-operative days. In all cases operated hitherto, good to satisfactory return of function has been observed. The earliest onset of function-return was observed at four (4) months after the operation and the latest completion occurred at eighteen (18) months. Thus far, no negative results have been observed using this method.

Facial Nerve↗
PubMed1979

[Clinical forms of venous leg ulcers].

The different clinical features of venous leg ulcers have different etiology and pathogenesis, and therefore require different therapy. One should distinguish between ulcerations with origin in the external or internal fascia; also between periphlebitic, engirdling, "blow-out", hypodermitic and siderosclerotic ulcers, and between ulcers due to erosion or venous stasis. The differentiation into leg ulcers caused by rheumatoid disease, hematological disorders and organic diseases of large and small vessels is of importance for the proper treatment.

Humans↗
PubMed1979

[Compression therapy].

Elastic support is of primary importance for the treatment of chronic venous stasis. Elastic pressure bandages are helpful to remove edema and to restore venous reflux. Elastic pressure stocking can, if properly applied, maintain the improvement and avoid new swelling. The compression is standardized in four different degrees each having its own indication. Bedstockings should be used of patients confined to bed in order to prevent thrombophlebitis. Inflated supportive devices with changing air pressure have their own limited application.

Bandages↗