Toad-lickers psychosis--a warning.
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Animals↗
Biomedical subjects
H Foerstl
Publications and source records attributed to H Foerstl.
"Pseudodementia" and "pseudodepression": a short review on the coexistence of cognitive and affective impairment in the elderly.
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Cognition Disorders↗
Multiinfarct and Alzheimer-type dementia investigated by transcranial Doppler sonography.
Primary degenerative dementia of the Alzheimer type and multiinfarct dementia exhibit differences in cerebrovascular blood flow velocity profiles, which were investigated by transcranial Doppler sonography. The pulsatility indices, as angle-independent parameters of peripheral vascular resistence, measured in middle cerebral and basilar arteries of patients with multiinfarct dementia were significantly increased (p less than 0.005) compared with cases of primary degenerative dementia of the Alzheimer type and with healthy age-matched controls.
Aged↗
Capgras' delusion: an example of coalescent psychodynamic and organic factors.
The case of a 33-year-old woman with a right hemisphere lesion after subarachnoid bleed is reported. She developed the false belief that her husband, her mother, her children, and herself had been replaced by doubles after the birth of her fourth daughter. The multifactorial etiology of the Capgras delusion is discussed with a brief review of the literature.
Adult↗
Association analysis of genes involved in cholesterol metabolism located within the linkage region on chromosome 10 and Alzheimer's disease.
Epidemiological studies identified a higher risk of developing Alzheimer's disease (AD) among subjects with elevated cholesterol levels. This association may be caused by a modulation of the amyloid precursor protein (APP) processing in response to the cellular cholesterol content. High cholesterol levels may favor the amyloidogenic pathway by inhibition of the alpha-secretase probably leading to elevated beta-Amyloid (Abeta) production. The identification of a linkage peak on chromosome 10q using high Abeta as quantitative trait led us to examine polymorphisms of genes located on chromosome 10 involved in cholesterol metabolism, like Lipase A (LIPA), Cholesterol 25 hydroxylase (CH25H), and FLJ22476, a high density lipoprotein binding related protein. Using 286 patients with AD and 162 controls we analyzed several single nucleotide polymorphisms (SNPs) within LIPA, CH25H, and FLJ22476. None of the polymorphisms showed significant association with AD which contradicts recent findings on CH25H. From our results we conclude that the investigated genetic variations do not contribute to the genetic risk of AD.
Aged↗