PubMed Health⌕ Search

Biomedical subjects

H Forster

Publications and source records attributed to H Forster.

30 records · Page 2Linked to original sources
PubMed1991

Characterization of the renal microvascular effects of angiotensin II antagonist, DuP 753: studies in isolated perfused hydronephrotic kidneys.

The renal microvascular effects of DuP 753, an orally active imidazole angiotensin II (ANG II) receptor antagonist were assessed directly in isolated perfused hydronephrotic rat kidneys. Unilateral hydronephrosis was induced to facilitate direct visualization of renal microvessels. Hydronephrotic kidneys were perfused in vitro and microvessel diameters were measured by automated computer-assisted image processing. The administration of 0.3 nmol/L ANG II decreased afferent arteriolar (AA) and efferent arteriolar (EA) diameters by 34 +/- 3% (from 17.9 +/- 0.6 to 11.9 +/- 0.6 microns, P less than .001, n = 11) and 28 +/- 3% (from 17.1 +/- 1.3 to 12.3 +/- 1.3 microns, P less than .001, n = 11), respectively. The subsequent administration of 0.1, 1.0, and 10 mumols/L DuP 753 reversed ANG II-induced vasoconstriction of the AA by 39 +/- 10%, 81 +/- 8%, and 103 +/- 9%, and of the EA by 22 +/- 7%, 51 +/- 6%, and 87 +/- 13%, respectively. These observations indicate that DuP 753 completely blocks both the renal afferent and efferent arteriolar actions of ANG II. In light of the pathogenetic role of ANG II in mediating the deranged renal hemodynamics associated with hypertension, congestive heart failure, and some forms of renal insufficiency, our findings provide a theoretical framework for future studies assessing the potential therapeutic applicability of DuP 753 in reversing ANG II-mediated renal vasoconstriction.

Angiotensin II↗
PubMed1989

[Conditions of the gingiva around endosteal implants with attached and unattached mucosa].

The condition of the peri-implant mucosa is critical for the long-term success of endosteal implants. 111 endosteal implants (IMC and Brånemark) were examined to see whether peri-implant gingival attachment to bone and peri-implant inflammatory reactions correlated with implant stability. A direct relation was found exist between peri-implant mucosal attachment and pocket depth around implants, while the severity of peri-implant inflammatory reactions did not correlate with implant stability. But this might be explained by the relatively short implant residence of 5 years at the time of the follow-up study.

Biocompatible Materials↗
PubMed1988

Effects of islet grafts of MHC-compatible donors on glucose metabolism in the spontaneously diabetic BB/Wor rat.

Complete recovery of the diabetic process occurred in spontaneously diabetic BB/Wor rats after the transplantation of islets of MHC-compatible donor rats. Islets were isolated from diabetes-resistant BB/Wor rats and were cultured for 4 days at 37 degrees C. The islets were then hand-picked and each BB/Wor rat with spontaneous diabetes received a total of 10 islets per g of body weight injected either into the immunologically privileged abdominal testis or into the non-immunologically favored renal subcapsular space. No immunosuppression was given to the recipients. After a period of at least 80 days of normoglycemia, the effects of an intravenous glucose injection on serum glucose and insulin levels were assessed. The grafts and the pancreases were then surgically removed and the insulin content of each organ site determined. The results showed that normoglycemia and a rapid weight gain were induced whether the rats were given an intratesticular or a renal, subcapsular islet graft. The amounts of extracted insulin recovered from the grafts after 83-259 days of normoglycemia were not significantly different from the pancreatic insulin content of age-matched control rats. But, despite the survival of a large mass of insulin-producing cells, glucose tolerance was impaired with a blunted insulin response and a delayed return of serum glucose to basal levels. Histologic examination of the islet grafts between 214 and 269 days after transplantation showed remarkable preservation of the islets with no evidence of an inflammatory reaction. Successful transplantation did not, however, lead to a recovery of the native pancreas of the BB/Wor recipient.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1984

[The changing picture of ski accidents. Evaluation of ski injuries during the 1981/1982 Winter in Bavaria].

During the last few decades a great change has taken place in the patterns of ski injuries. This could be shown by an evaluation of the ski accidents of winter 1981/82 in Bavaria. These accidents were compared with those of winter 59/60 in the same area. We found a significant increase in serious injuries, injuries of the head, the knee joints and the upper extremities. This is demonstrated by four cases. Consequences are discussed to improve the management of seriously injured skiers.

Adolescent↗
PubMed1977

[Effect of plant gums (swelling materials) on intestinal absorption in experimental animals].

The influence of various gums on the intestinal absorption of glucose and maltose was investigated in the experimental animal. The alterations in the concentrations of sodium and potassium were determined additionally. The following gums were used: alginate (sodium, potassium, calcium salts), Carrageenan, guaran, methylcellulose, carboxymethylcellulose. The absorption of glucose (concentration: 5% = 278 mmol/l) and maltose (concentration: 5% = 139 mmol/l) was not influenced by the addition of gums (concentration: 1%-2%). The hydrolysis of maltose was not inhibited also. Sodium was absorbed from the intestinal lumen if the concentration was higher than 120-150 mmol/l, otherwise sodium was excreted into the lumen. Potassium was absorbed if the potassium concentration was raised above 6-10 mmol/l, otherwise potassium was excreted into the lumen. The neutral gums did not influence the alterations in ion concentration. The gums tested do not influence the digestion and absorption of maltose or glucose. The acid gums are present in the small intestine in the form of their sodium salts. In the large intestine, sodium is exchanged for potassium.

Alginates↗
PubMed1976

Acute alterations in stroke volume during exercise at 3,100 m altitude.

Following 3 weeks exposure to an altitude of 3,100 m, the cardiac output response to upright submaximal exercise was examined in 3 healthy subjects breathing ambient air and breathing 60% oxygen. The procedure allowed acute alteration of the 2 conditions within a single testing period of 30 min, 60% oxygen breathing either preceding or following breathing ambient air. Cardiac output was also measured in two of the subjects during maximal exercise under these two conditions. Administration of the high oxygen inspirate during exercise had little effect on the level of cardiac output but resulted in an immediate bradycardia and a dramatic increase of approximately 16% in stroke volume. Stroke volumes during maximal exercise were also increased by approximately 10% by the administration of high oxygen. It is suggested that the condition of decreases exercise stroke volume which develops with chronic exposure to altitude may be largely the result of diminished myocardial contractility stemming from a condition of myocardial hypoxia.

Altitude↗