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Biomedical subjects

H François

Publications and source records attributed to H François.

At least 19 recordsLinked to original sources
PubMed1996

A curable cause of chronic idiopathic intestinal pseudo-obstruction in children: idiopathic myositis of the small intestine.

We report an intestinal pseudo-obstruction syndrome occurring in a 6-month-old infant girl suffering from acquired major and persistent abdominal distension, which 2 months later required ileostomy. Histologic examination of samples of the small intestine showed considerable inflammatory reaction in the muscular layers of the intestinal wall. Steroid therapy, begun as soon as the histologic results were known, resulted in recovery. In a similar case, reported previously, steroid therapy used after the lesions had already caused fibrosis and atrophy of the intestinal wall, proved ineffective. This particular form of pseudo-obstruction is classified as "idiopathic myositis of the small intestine." It is important to identify the condition because an early course of steroid therapy, before the appearance of fibrotic lesions, could improve the prognosis.

Female↗
PubMed1996

[Total rectal prolapse in children. Diagnostic and therapeutic trends. Statistics apropos of 52 cases].

Rectal procidentia represents classically only 2% of rectal prolapse in children. This rarity is more apparent than real, because peritoneographies showing the excess of migration of the rectogenital pouch, allows to diagnose more often this pathology. The normal trend of this anomaly of the infant and the young child even if it could be serious with strangulation is usually a spontaneous healing. Accordingly therapeutic indications should be cautious. Surgery is only indicated in confirmed or complicated forms. After analysis of the statistic of 52 observations, the modified Lockhart-Mummery is our prefered procedure. It needs a short and simple surgery and the results appear satisfactory.

Age Factors↗
PubMed1996

[Trophoblastic tumor on the placenta. Diagnosis, prognostic factors, treatments].

Previously known under other terms, placenta site trophoblastic tumor (PSTT) is a specific entity among trophoblastic diseases. Outcome is highly variable depending on the clinical course which may range from benign disease to high-grade malignancy. Histology and biology, including mitotic count, the degree of tumor invasion, the process of necrosis within the tumor and plasma beta-hCG level, provide important indications for prognosis. Survival without recurrence can be achieved with wide surgical excision. Complete hysterectomy with or without bilateral salpingooophorectomy is required. Chemotherapy and radiotherapy have no effect. In case of desired pregnancy, the acceptability of conservative treatment must be judged on the basis of hysteroscopy with MRI or endoscopic sonography findings. In cases with good prognosis, conservative management may be proposed with hysteroresection for an endouterine tumor or complete resection of the PSTT, the uterus remaining in situ during the laparostomy. Obstetrical prognosis, still to be determined, depends on the validity, feasability and fertility rate after such procedures. Curettage must be abandoned.

Adult↗
PubMed1994

[Calcifying fibrous pseudotumor].

The case of a 17-year-young woman with Calcifying Fibrous Pseudotumor is reported. This observation emphasizes 1) A distinctive histologic appearance and the broad spectrum of this entity, 2) The differential diagnosis to consider, 3) The excellent prognostic and the low risk of local recurrence.

Adolescent↗
PubMed1992

[Peritoneal dirofilariasis fortuitously disclosed].

Peritoneal dirofilariasis probably due to Dirofilaria repens is reported from a 52 years old woman. The parasite discovery is fortuitous during a surgical cure of intestinal adenocarcinoma. The patient lives in Provence and Corsica (Southern France), an endemic region. The authors present the histological aspects of the parasite.

Dirofilariasis↗
PubMed1992

[Endometriosis and diaphragmatic defect in catamenial pneumothorax].

Two cases of catamenial pneumothorax are reported, a rare condition characterized by its sudden occurrence in a female patient between the ages of 30 and 40 years, always at the onset of the menstrual cycle. Its exact origin is unknown, but the frequent co-existence of endometriosis and a defect in the diaphragm suggests that endometriosis may be important in the etiology both of the pneumothorax and the diaphragmatic lesion. Pelvic endometriosis was present in both our patients, one of whom also had diaphragmatic endometriosis. The treatment of the pneumothorax in both our cases consisted of pleural decortication with excellent results so far.

Adult↗
PubMed1991

[Calcificated necrotic inflammatory granuloma after intradiscal injection of triamcinolone hexacetonide].

Recently, it has been demonstrated that symptomatic epidural calcifications represent a complication of intradiscal injection of triamcinolone hexacetonide (Hexatrione). Out of our three cases, pathological examination showed lesions of necrosis with granulomatous inflammatory reaction and bone metaplasia. Necrosis seems to be the primary cause of calcifications so we propose to call the lesion inflammatory and necrotic granuloma. The incidence of these granulomas is unknown. They are unpredictable and appear with a mean range of a year following the intradiscal injection. The treatment is surgery if they become symptomatic.

Anti-Inflammatory Agents↗
PubMed1989

[Eruptive collagenoma. Apropos of a case with ultrastructural study].

A 29-year-old male patient was examined for numerous asymptomatic dermal nodules symmetrically distributed over the back and the shoulders. The nodules were firm, round to oval and varied in size from a few millimeters to 2 centimeters. They had appeared in normal skin without any known previous inflammation or injury, and they has been present without modification for nine years. At histological examination a dermal accumulation of abundant and large collagen bundles was observed. Elastic fibers seemed to be less numerous than normally. Alcian blue showed no increase in acid mucopolysaccharides. An ultrastructural study displayed normal, mature collagen fibers arranged in large bundles. Cutaneous collagenoma, initially described by Colomb as "eruptive collagenoma" is a rare disorder of unknown etiology occurring in young adults as symptomless dermal nodules without previous history of illness or injury and mostly localized to the back. No change is usually observed in these nodules for several years. Histologically, the nodules are characterized by a proliferation of collagen in the dermis; elastic fibers are generally reduced in number. Our ultrastructural study showed that proliferation of normal collagen fibers is the main morphological finding.

Adolescent↗
PubMed1989

[Endometriosis and ureteral stenosis. Apropos of 4 cases].

If endometriosis is particularly well known by Gynecologists, ureteral complications of this disease are very rare. We have had the occasion to observe four cases of ureteral stenosis by extrinsic compression of a pelvic endometriosis, and about these four cases, we have reviewed one hundred and fifty six cases in literature. We have emphasize that the fibrosis provoked by endometriosis can look like a neoplastic lesion, and get involved in very heavy therapeutic gestures. We insist on the fact that every endometriosis discovered should be on surgery of kidneys and ureters.

Adult↗
PubMed1988

Prostate-specific antigen (PSA) in the management of 500 prostatic patients.

Blood samples from 500 patients with clinical prostatic symptoms were radioimmunoassayed with prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP) kits. On the basis of histological data, directed by PSA results and other investigations, 200 prostatic cancers (adenocarcinomas), 276 benign prostatic hypertrophy (BPH), 16 cases of prostatitis, 5 cancers of the bladder, and 3 prostatodynias were diagnosed. All of the serum samples from prostatic cancer patients showed elevated PSA levels at diagnosis, whereas about 70% of these showed normal PAP values. The sensitivity of the PSA assay is 100% when 2.5 ng/ml is taken as the upper limit of normal. However, the specificity and the positive predictive value are better at 10 ng/ml: 99 and 79%, respectively. High PSA values alerted the clinician when diagnosing a cancer without symptoms on rectal or ultrasonographic examination (3%). In BPH, when the PSA level is between 2.5 and 10 ng/ml, a PSA control must be performed within 2 months. If PSA increases above 10 ng/ml, the risk of cancer has to be considered. In the follow-up, PSA is a better marker than PAP to detect disease progression and seems to constitute an evolutive tumor mass index. PSA is the most sensitive, the earliest, and the most prognostically reliable marker for diagnosis and follow-up of prostate cancer patients.

Acid Phosphatase↗
PubMed1987

[Treatment of chondrosarcoma of the tibia by cryosurgery. Apropos of 2 cases].

Two grade II central tibial chondrosarcomata of have been treated by extensive curettage and cryotherapy as described by Marcove. No recurrences or metastases were present after a follow-up of six and eight-and-a-half years respectively. A review of the treatment of these tumours was made and the advantages and disadvantages of liquid nitrogen considered. The indications for cryosurgery are described. The frequency and time of onset of recurrences and metastases is discussed in the light of published papers.

Adult↗
PubMed1987

[A case of very destructive dorsal spondylodiscopathy surgically treated in ankylosing spondylitis complicated by amyloidosis].

An ankylosing spondylarthritis was complicated by a D9-D10 spondylo-discopathy, with severe destructive alterations. After strict immobilization for three months, when the lesions partly regressed, non-steroid anti-inflammatory (NSAI) drugs were unable to cause a cure. An excellent result was obtained with a surgical arthrodesis after 5 years. The vertebral location was filed with fibrous tissue. The patient died from an amyloid disease with renal insufficiency. The presence of amyloid tissue in the vertebral location did not prevent a good healing of the vertebral arthrodesis.

Adult↗
PubMed1984

[Computed x-ray tomography in the detection of venous extension in renal cancer].

With reference to eleven cases of renal cancer with involvement of the inferior vena cava, CT semeiology of this venous complication is detailed. Furthermore, the authors suggest that the images are capable of a pathological interpretation which may indicate whether the obstruction is caused by the tumor or a thrombus. Lastly, the value and limitations of CT scan for detecting caval obstructions associated with renal cancer are analyzed.

Adult↗