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H Franke

Publications and source records attributed to H Franke.

At least 19 recordsLinked to original sources
PubMed1992

Quantitative studies on fatty acid metabolism in isolated parenchymal cells from normal and cirrhotic livers in rats.

Parenchymal cells isolated from normal and thioacetamide-induced micronodular cirrhotic rat livers were used to evaluate changes in hepatocellular fatty acid (FA) metabolism in cirrhosis. Exogenous free FA (FFA) are rapidly taken up by hepatocytes obtained either from normal or cirrhotic livers. They are predominantly esterified to triglycerides and accumulate intracytoplasmatically as lipid droplets with increasing cellular FFA uptake. In the parenchymal cells of cirrhotic livers, however, the following changes were observed when compared with controls: (i) decreased cellular output of esterified FA derived both from exogenous sources and from de novo FA synthesis; (ii) increased total ketone body production, mainly as beta-hydroxybutyrate; (iii) decreased cholesterol synthesis; and (iv) enhanced incorporation of newly synthesized FA into phospholipids in spite of an unaffected rate of FA synthesis. In summary, the data provide evidence for intrinsic alterations in the lipid metabolism in the parenchymal cells of cirrhotic livers which are preserved in the isolated hepatocytes under optimum incubation conditions for oxygen and substrate supply.

3-Hydroxybutyric Acid↗
PubMed1979

[Multiple illnesses of the gastrointestinal tract. Part 2: So-called second diseases of the upper abdominal organs].

Today are multiple illnesses, pertaining the internal maladies (illnesses), almost a regularity. You differentiate between combination-illnesses, which represent primarily dependent illnesses and associated illnesses independent from each other. In the following summary illnesses are mentioned, which according to present information, appear more often together or cancel each other out. Of special interest are such procedures, by which a second disorder to the one existing can appear. The patient will experience a change in his illness. The appearance of a so called second sickness is especially to be observed in such organs as liver, gallbladder and pancreas. The study of multiple illnesses is more meaningfull, because statements for the basic research can be met and next to these more aetiologic or pathogenic associated questions lead to the next step, to the clinical symptoms which experience a change, and further to certain therapeutic considerations and consequences. Finally also the prognostic statements change.

Biliary Tract Diseases↗
PubMed1979

Studies on the ultrastructure of the term amnion in pathological pregnancy.

The ultrastructure of the amniotic epithelium at term was examined in cases of intrauterine growth retardation of the fetus and compared with amnions obtained from women with a clinically unremarkable pregnancy. In uterine growth retardation the amniotic cells exhibit a general deficiency of a series of functionally significant cell organelles. The RER is insufficiently developed, there is a diminution of the normally numerous free ribosomes as well as of those cell organelles which are involved in secretory function. A further atypical finding is the common lack of intercellular canals playing an important role in the transamniotic exchange of material. Besides this, a very poor development or a complete disintegration of the microfilamentous cytoskelet is generally noticed. The present findings give once again evidence for a very close relation between the structural appearance of the intercellular diffusion canals and the microfilamentous system. The results presented are suggestive of an amnion which is in a state of reduced secretory activity, additionally, due to the common lack of intercellular canals an inhibition of the interepithelial passage between the maternal and amniotic compartment cannot be excluded.

Amnion↗
PubMed1979

[Theories of longevity (author's transl)].

Any modern theory of longevity has to take into account the multifactorial combined effect of biological-medical, social and psychological factors and of factors pertaining to molecular biology, each with their different weighting. For this reason research into greater-than-average life expectancy and longevity is only possible on an interdisciplinary basis. Many theories of longevity despite convincing arguments also have their weak points. Critical analysis of the theories available to date reveals that longevity rests on an optimal combination of two major factors: 1. on a genetic predisposition in people with longevity in the family--this is the case in most instances. 2. on additional exogenous factors of a social, psychological, ecological and medical kind.

Aged↗
PubMed1979

[Ligation of the yolk sac circulation and its effect on the yolk sac ultrastructure and development of the rat fetus].

The effect of an interruption of the yolk sac circulation on the rat visceral yolk sac and the development of the fetoplacental unit was examined in the last third of pregnancy. The yolk sac ischaemia was induced by ligating the blood vessels of the yolk sac stalk which connect the vitelline circulation with that of the fetus. A 3-hour ligature caused an extensive swelling of most cell organelles in the epithelial cells and in the capillary endothelia of the yolk sac. Other structural changes were indicative of a cessation of pinocytosis. A 6-hour ligature resulted in a common increase of cell swelling and in a beginning disintegration of the endothelial cells lining the vitelline capillaries. A 15-hour ligature caused severe ultrastructural cell lesions and macroscopical alterations suggestive of a progressive necrolar finding of a nearly complete loss of the amniotic fluid and the death of the fetus, although the maternal blood flow appeared to be still intact in the placenta.

Amniotic Fluid↗
PubMed1978

Findings in computerized axial tomography after intrathecal methotrexate and radiation.

Medulloblastoma and acute lymphocytic leukemia patients treated by intrathecal methotrexate and radiation were investigated by means of computerized axial tomography. More than 50% of them turned out to have acquired encephalopathy. Only gross morphologic brain defects, as visualized by computerized tomography, caused manifest clinical signs of brain dysfunction, such as epilepsy, mental retardation, paresis, and apallic syndrome. Mild morphologic changes were found even in asymptomatic children. The preferred site of defects in brain substance was the paraventricular white matter.

Brain↗
PubMed1978

Improved sodium and PAH transport in the isolated fluorocarbon-perfused rat kidney.

The effect of an artificial O2 carrier (emulsion of the perfluorochemical FC43 with Pluronic-F-108) on the functional capability of the isolated perfused rat kidney was tested. In control series hydroxyethyl starch (HES) instead of fluorocarbon was used. Improving O2 supply in FC 43 experiments raised Na reabsorption to 149 mumol/g x min compared to 84.1 mumol/g x min in HES experiments. In the presence of PAH, however, Na reabsorption in FC 43 experiments was only 115 mumol/g x min. In both series, perfusion flow, calculated on the basis of CPAH, remained below the directly measured flow rate, unless analysis included all metabolites of PAH. N-acetylated metabolites of PAH were released at a 5 times higher rate by kidneys perfused with FC 43 than by HES-perfused organs. These results demonstrate that sufficient O2 supply is critical both for reabsorption of Na+ and for handling of PAH. Increased tubular Na reabsorption in the absence of PAH indicates that even during perfusion with FC 43 O2 supply is marginal.

Acylation↗
PubMed1977

[The idiopathic respiratory distress syndrome from the obstetrical point of view].

Frequency of idiopathic respiratory distress syndrome (IRDS) of low birth weight children was examined over 15 years (1960 to 1975) in the Frauenklinik of the Ernst-Moritz-Arndt-University of Greifswald. Possible pathogenetic risk factors were proofed. The validity of the Apgar-score and blood gas analyses for the development of IRDS was investigated. Finally, the coincidence between mode of delivery, early rupture of membrane and imminent intrauterine infection in relation to the frequency of IRDS was shown.

Apgar Score↗
PubMed1977

[The different inactivation of isoniazid in intermittent chemotherapy (author's transl)].

A ratio-test (Isoniazid: acetyl-isoniazid) is used for phenotyping the Isoniazid-inactivation. The border-line between both the phenotypes is determinated. The influence of age and weight of the patients is studied. Usefully results are obtained after application per os of an uniform dosage and a sampling period for urine of 4 hours. Increasing the dosage to 900 mg the portion of isoniazid arises mmore than proportionally, more distinct in rapid than in slow inactivators. Therefore the differences between the two phentoypes are diminished. The clinical importance of these results is discussed.

Adult↗
PubMed1977

[Electron microscopic investigations on the influence of lymphocytes of sensitized and non-sensitized guinea pigs on the visceral yolk sac epithelium of the rat (author's transl)].

Rats on day 19 of pregnancy were intrauterinely injected lymphocytes from guinea-pigs, sensitized or not sensitized to trophoblast antigens of the rat placenta. In the first case locally severe cytolytic effects were observed on the yolk-sac surface, in the second case--the controls--no immune reaction was evident.

Animals↗