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Biomedical subjects

H Franken

Publications and source records attributed to H Franken.

9 recordsLinked to original sources
PubMed1996

Head injuries from bicycle accidents.

This study comprises a total of 159 victims from bicycle accidents treated as inpatients at the Department of Neurosurgery, University of Bonn between January 1987 and June 1995. It was our aim to define the severity and features of bicycle-related head injuries in a defined population. Our results show that 33% of admitted bicycle victims sustained severe head injuries (Glasgow Coma Score 3-8). Neurosurgical operations were performed in 49% of patients and were mainly related to the evacuation of an extracerebral hematoma. Of the 159 bicycle victims, 112 (70%) made a good recovery, 11 (7%) remained moderately and 4 (3%) severely disabled, and 26 (16%) had died at follow-up (mean 2 years). In conclusion, our data indicate that bicycle-related trauma accounts for a substantial proportion of all head injuries requiring neurosurgical treatment. Active (e.g. traffic regulations, education of riders) and passive measures (e.g. safety helmets) can be expected to reduce both incidence and severity of head injuries among bicyclists.

Accidents, Traffic↗
PubMed1989

Plasma spermidine and putrescine as markers of cancer management.

The hypothesis was tested that dying tumor cells release spermidine and putrescine into the bloodstream. Therefore, a rhabdomyosarcoma was implanted in rats, irradiated and its growth and subsequent reduction compared with spermidine and putrescine plasma concentrations of the venous effluent from the tumor side and contralateral side. In the experimental set-up used the hypothesis could not be verified. It appeared that irradiation only, implantation and growth of a tumor only and an irradiated tumor, all caused elevated spermidine and putrescine concentrations in the effluent of both sides in approximately the same order of magnitude, compared to untreated controls.

Animals↗
PubMed1985

Forced oscillation technique: comparison of two devices.

The respiratory impedances in healthy subjects and patients with advanced obstructive lung disease were measured between 2 and 32 Hz, using two forced oscillation techniques: the setup used previously by Grimby et al. (J. Clin. Invest. 47: 1455-1465, 1968) and a modified device in which the pneumotachograph is replaced by a 2-m-long tube and the ratio of pressures at both ends of the tube is determined. The advantages of the latter device are that 1) its impedance and frequency characteristics can be predicted by classical physics, 2) the only requirement for correct measurements are a match of the pressure transducers, and 3) high-pass filters are not needed to suppress the influence of breathing. On the other hand, the device is more sensitive to the turbulences induced by the subject's own breathing. This drawback can be avoided by interposing a piece of tubing between the mouth and proximal pressure recording site.

Airway Resistance↗