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Biomedical subjects

H Frisch

Publications and source records attributed to H Frisch.

At least 37 records · Page 2Linked to original sources
PubMed1979

[Intestinal obstruction following necrotizing enterocolitis (author's transl)].

The increase in survival from necrotizing enterocolitis results in an increased rate of late sequelae. We would like to take the opportunity to emphasize these new complications by a review of our patient material. 11 (23.9%) patients from a total number of 46 showed signs and symptoms of intestinal obstruction at different points in the course of the disease. In two surviving patients out of this group of 11, a resection of postinflammatory gut stenosis had to be performed within the first year. In the 9 children who died, particular emphasis is being paid in the autopsy reports to obstructive lesions in the gastrointestinal tract. Due to this rather frequent event (23.9%) of postinflammatory formation of strictures and stenoses in the recovery from NEC a functional radiographic study of the intestinal patency seems mandatory before discharge of any patient with NEC with operative or conservative treatment.

Enterocolitis, Pseudomembranous↗
PubMed1978

[Delivery of a normal child after chemotherapy of acute promyelocytic leukaemia during pregnancy (author's transl)].

Upon chemotherapy with daunorubidomycin and cytosinarabinoside, a patient suffering from acute promyelocytic leukaemia during the 28. week of pregnancy achieved complete haematological remission. In spite of complicating disseminated intravascular coagulopathy and aggressive chemotherapy a normal child was delivered by cesarian section during the 34. week of pregnancy. Specific problems in the treatment of acute leukaemia during pregnancy are discussed.

Cesarean Section↗
PubMed1978

[Ring chromosome 15 in a child (author's transl)].

A report is given of the occurrence of a ring chromosome 15 in a 5.6 year-old girl. The features of this case are mental retardation, small stature, microcephaly, malformation of the kidney, congenital heart disease and congenital dislocation of the hips. The features of this syndrome are very variable. Only 4 cases have been described up to 1975.

Child, Preschool↗
PubMed1978

Bayley-Pinneau, Roche-Wainer-Thissen, and Tanner height predictions in normal children and in patients with various pathologic conditions.

Bayley-Pinneau, Roche-Wainer-Thissen, and Tanner height predictions at various chronologic ages were compared with final adult height in 56 normal subjects and in 34 patients with abnormal growth pattern (11 with familial tall stature, 7 with idiopathic precicious puberty, 6 with Turner syndrome, and 10 with primordial small stature or Silver-Russell syndrome). The two recent methods (Roche-Wainer-Thissen and Tanner) gave very accurate results and were superior to the Bayley-Pinneau method in normal subjects and in patients with familial tall stature. However, they overestimated adult height grossly in precocious puberty and moderately in Turner syndrome and in primordial small stature. It is concluded that calculations based on coefficients and regression equations obtained from normal children (as in the Roche-Wainer-Thissen and Tanner methods) can only be used in normal children or in patients with normal growth potential under adequate treatment. Calculations based on percentages of adult height (as in the Bayley-Pinneau method) are preferable in conditions in which the growth potential in relation to bone maturation is inherently reduced and cannot be corrected by treatment.

Adolescent↗
PubMed1978

[Duodenal ulcer in a newborn infant with gastro-intestinal hemorrhage (author's transl)].

A newborn infant was transferred to our hospital because of gastro-intestinal hemorrhage, starting a few hours after birth. Because of fetal distress a cesarean section had been necessary. The clinical examination as well as the results of the laboratory tests revealed nothing abnormal. In an upper gastro-intestinal X-ray series there was evidence for a duodenal ulcer. Under conservative treatment the baby recovered and has remained in a good condition without any bleeding episode until now. A repeat upper gastro-intestinal X-ray series was done at the age of 5 months and no evidence of ulceration could be found. The incidence and the reason of such an ulcer in the new born period is shortly discussed.

Duodenal Ulcer↗
PubMed1978

[Artificial ventilation of preterm and term infants (author's transl)].

One of the first aims of the neonatal care unit of the Paediatric Department of the University of Innsbruck (Austria) consists in taking care of dangerously ill children of Tyrol including the neighbouring federal states and the alpine part of Italy (South Tyrol). From SUMMER 1974 to the end of October 1976 1342 preterm and term infants were treated. 142 of these children died (mortality rate 10.5%). In 94 patients, i. e. 6.9% mechanical ventilation was necessary. 39 of these children, i. e. 41.5% survived. Two indications of artifical ventilation were predominant: Hyaline membrane syndrome in 59 children (survival rate 49%) and apnoe in 22 children (survival rate 27%). Electroencephalography was performed in 39 children during the neonatal period. 34 of these children were severely ill (gestational age of 24 to 37 weeks), 5 children were born at term nevertheless moribund. 18 of the 23 dead children of this group showed severe alterations in electroencephalography. The cause of death of 10 of these children was cerebral bleeding as verified by autopsy. 8 of the 16 surviving children showed a regular psychomotoric development, 5 children of this group had a normal electroencephalogram.

Apnea↗
PubMed1978

[Fosfomycin, a new antibiotic drug (author's transl)].

After i.v. injection of 25 mg/kh/BW and 50 mg/kg/BW to children age 5--6, no difference in the pharmakokinetic action can be found. The pattern of the plasma concentration allows the assumption of a 2 compartment model. There is a decrease of the plasma concentration in the steady state with a half life of 1,6 and 1,7 hours resp. The total volume of distribution is 30% of the body weight. Fosfomycin is eliminated by glomerular filtration only. The drug is not metabolished, as 98% and 95% of the dosage are recovered in active form in the urine. In premature and newborn babies there was a 1 compartment model assumed after i.v. administration of 25 mg/kg/BW. The distribution volumes with 41% of the body weight considerably greater then in older children. Elimination is again by glomerular filtration only. Plasma levels are decreasing considerably slower so that less of the drug is excreted in the 24-hour-urine. There is a sufficient penetration of the drug into the CSF. Bactericidal levels are reached within 48 hours by cumulation of the drug.

Age Factors↗
PubMed1978

[Bird-headed-dwarfism. A case report (author's transl)].

The case history and symptoms of a girl aged 12 months are reported suffering from bird-headed-dwarfism or Seckel-Syndrom: low birth weight in spite of prolonged pregnancy, typical "bird-headed-face", mikrocephaly, dwarfism, dystrophy, mental-motoric retardation.

Abnormalities, Multiple↗
PubMed1978

[Heroin-withdrawal-syndrome in the newborn (author's transl)].

A case of a heroin-withdrawal-syndrome is reported. Diagnostic, therapeutic and social aspects of this syndrome are discussed. Newborn infants delivered from mothers addicted to heroin often develop a deprivation syndrome. 40% of these children are small for date babies. Symptoms of deprivation begin after delivery or between the 1st and 4th week of life. Generally the onset of symptoms lies between the 1st and 3rd day of life with irritability, tremor, restlessness, and shrill cry. The degree of illness depends upon mother's last heroin intake. Treatment for drug addicts are tinctura opii (3--5--10 drops orally following 4 hours) and Chlorpromazine (2,2 mg/kg/25 hours orally or i. m.). The mortality rate increases when treatment is missing.

Electroencephalography↗
PubMed1978

[Thrombosis of the renal artery in a newborn (author's transl)].

Very rare informations about thrombosis of the renal artery in newborns in the literature could be found. In a six years old girl in the course of a perinatal asphyxia complicated by shock a renal artery thrombosis was observed. Profuse bleeding, anemia, thrombopenia, prolonged bleeding time and coagulation time and a low percentage of the thrombotest suggested an intravascular coagulation as a possible factor of this disease. The treatment of the coagulopathia was effective. The physical and psychical development of the girl is normal. The inhibition of the renal function, however, is in a compensated state.

Child Development↗
PubMed1978

[Thanatophoric Dwarfism (author's transl)].

Four cases of thanatophoric dwarfism which appeared between 1974 and 1977 are described. Thanatophoric dwarfism was firstly described in 1967. In the mean-time there are reports about 44 cases. The frequency of thanatophoric dwarfism is considered to be 1 to 6393 newborns. There is no clear evidence about the occurrence of thanatophoric dwarfism, chromosone patterns have been always normal. This type of dwarfism is differentiated from other similar syndromes.

Diagnosis, Differential↗
PubMed1978

[Prevention of neonatal apnea with theophylline (author's transl)].

To the well known methods for prevention of neonatal apnea like stimulation, CPAP, and mechanical ventilation the treatment with theophylline has been added recently. We studied the efficiency of theophylline therapy in 10 premature infants with apnea. The initial dosage was 6 mg theophylline/kg body-weight, followed by a dosage of 2 mg/kg for the next 12 h. The frequency of apnea thereby was significantly reduced. Only in two cases the heart rate rose above 180/min as a side effect. In no case an additional therapy was necessary.

Apnea↗
PubMed1977

Response of gonadotropins to stimulation with luteinizing hormone -- releasing hormone (LH-RH) in children with precocious puberty before, during and following therapy with cyproterone acetate or an ethisterone derivate.

9 children with precocious puberty were treated over a period of 6 months to 6 3/12 years with Cyproteron acetate or an Ethisterone derivate. LH-RH tests with radioimmunological estimations of LH and FSH were performed before therapy was begun, during and after completion of treatment. In children with untreated precocious puberty the mean basal LH levels were the same as in normal prepubertal children but the increase and the peak values after i.v. LH-RH were found to be considerably greater than in normals. In the treated patients this stimulatable LH release was suppressed; after completion of therapy it was again elevated. The basal FSH levels in untreated children were elevated; however the increase and the peak values were comparable to the collective norm. Results were not altered considerably by therapy, however these parameters were given elevated after completion of therapy. Despite the marked suppression of stimulatable LH by therapy acceleration of bone age is practically not affected. After completion of therapy this drug-induced suppression of gonadotropines is promptly reversible.

Age Determination by Skeleton↗
PubMed1977

[Influence of the age of old primiparae on the perinatal infant morbidity and mortility (author's transl)].

157 old primiparae (greater than 30 a) have been compared to a randomised control group of primiparae between the 16th and 30th year of age. In addition to the perinatal infant mortality rate, the number of children with malnutrition, the frequency of premature babies, the presence of a low Apgar score (less than or equal to 7) and pathological pH-values in the umbilical artery (pH less than or equal to 7,10) were cheked. Moreover the frequency of early neonatal morbidity (presence of one of the following criteria: 1 minute Apgar score less than or equal to 7, pH of the umbilical artery less than or equal to 7, 10, a transitoric or severe RDS and neurological complications during the newborn period) was investigated in both groups. In the group of the old primiparae a significantly higher perinatal infant mortality rate was found compared to the control group (3,8% versus 0,6%, p less than 0.05). The rate of small for date babies was remarcably higher than in the control group (14,6% versus 6,4%, p less than 0.05). There was no difference in the prematurity rate in both groups. The children of old primiparae had more frequently a low Apgar score (less than or equal to 7) than infants of the randomised control group (18,5% versus 11,5%), but the difference is statistically not significant. Furthermore no difference in the number of pathological pH values in the umbilical arteries (pH less than or equal to 7, 10) were found in the both groups. The children of old primiparae show a higher early neonatal morbidity rate compared to the control group (21.7% versus 14.0%); however, the difference is statistically not significant. According to our results the risk for the newborns is increased already with primiparae over 30 rather than 35 years of age.

Adult↗
PubMed1977

[Cerebral gigantism (Sotos-syndrome) (author's transl)].

Case report of a nine month old girl with Cerebral Gigantism. It is a gigantism syndrome characterized by advanced bone age, a typical craniofacial dysmorphia and a not progredient mental retardation. Etiology and pathogenesis of this syndrome are unknown.

Abnormalities, Multiple↗
PubMed1977

[A new antigonadotropin in the treatment of precocious puberty and pubertal gynaecomastia (author's transl)].

A synthetic steroid compound derived from testosteron (isoxazol-ethisterone), Danazol, with gonadotropin-depressing activity, was used in the treatment of 4 cases of idiopathis sexual precocity (age 2 1/2 to 4 years) and in 10 cases of severe pubertal gynaecomastia. In sexual precocity the suppression of menstruation as well as of breast-enlargement was good, while the suppression of acceleration of longitudinal growth and bone maturation was inferior compared with cyproteron-acetate. In most boys with gynaecomastia a marked regression of breast enlargement occurred within a few weeks or months. With the dosage used (200-300 mg/day in the sexual precocity patients, 300-400 mg in the gynaecomastia patients) the changes in plasma hormone levels (LH, FSH, progesterone, estradiol, testosterone) were within a non significant range. Depression of testosterone seemed to be a rather regular finding. No untoward side-effects of the medication were noticed in the 14 patients studied. In summary, Danazol did not show any advantages compared with the compounds used in the treatment of isosexual precocity sofar. In contrast, the drug proved to have useful effects in pubertal gynecomastia, a condition which in severe degrees certainly deserves medical treatment.

Adolescent↗