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Biomedical subjects

H Fritzsche

Publications and source records attributed to H Fritzsche.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Diagnosis of radionuclide uptake using samples and excretion measurements].

Diagnosis of internal contamination with radionuclides can be achieved by body or organ counting and by analysis of samples of intake or excretion. Sample counting from air, drinking water, food etc. is preferred in environmental contamination and may be used to estimate average body burden and internal dose. For complete monitoring of intake numerous samples have to be measured. Unknown internal contamination with alpha and low energy beta emitters is detected by excretion analysis. For determination of body or organ burden, based on standard man models, time and frequency of intake, physical, chemical and biological behaviour of radionuclides have to be taken into account. Sample sources are mainly urine, feces, exhaled air and in special cases sweat, blood and hair. The collection of excreta needs the cooperation of the contaminated individuals. The results of analysis is usually delayed because of time consuming radiochemical procedures. Repetition of measurement is necessary to increase precision of dose estimate and for detection of single, recurrent or continuous uptake.

Accidents↗
PubMed1986

[A so-called atypical adenoma of the thyroid in an endemic struma area].

In view of the benign clinical course of the atypical adenoma and the high diagnostic accuracy of our frozen sections we feel that subtotal strumectomy with in toto removal of the adenoma and closely spaced follow-ups constitutes an adequate treatment of this thyroid neoplasm. In our opinion primary lobectomy means unnecessarily exposing a disproportionately high percentage of patients to the higher complication risk of this more radical surgery. From 1977 to 1982 there were 47 cases of atypical adenoma among our patients. The ratio men: women was 1:3.7, the mean age of the patients was 44 years. The patients underwent subtotal strumectomy. In the period under review "atypical adenoma" diagnosed on the basis of frozen sections turned out to be carcinoma in 5 instances. The follow-up period of the 47 patients that underwent surgery ranges from 1 1/2 to 7 years. None of the patients has had tumor regrowth so far.

Adenoma↗
PubMed1985

[The supply of iodine in the province of Vorarlberg].

For evaluation of iodine supply in Vorarlberg, Austria, iodine urine excretion was measured in 299 patients. The Mean was 74,3 +/- 53,6 micrograms J/g Cr, the Median 61 micrograms J/g Cr. 79% of the patients showed an iodine deficiency I according to WHO classification and 41% an iodine deficiency II. In this patient group were included 44 subjects with no thyroid disease who showed an iodine excretion of 70.8 +/- 56,5 micrograms J/g Cr and a Median of 50,5 micrograms J/g Cr. There was no statistical difference to the values of the patient group. Regional evaluation of iodine supply showed an iodine deficiency I in 78% and an iodine deficiency II in 38% in the industrial region of the Rheintal. In the region Walgau with mixed industrial-rural population an iodine deficiency I was found in 81% and an iodine deficiency II in 45%. In the rural areas of Bregenzerwald and deep valleys an iodine deficiency I could be demonstrated in 81% and 83% respectively and an iodine deficiency II in 47 and 57% respectively. This moderate but statistically not significant differences show the minor influence of alimentation in iodine supply. Assuming a constant table salt consumption the results support the common belief that iodine supply in iodine deficient areas is strongly connected to incorporation of iodinated table salt. Therefore an increase of the iodination of table salt in Austria seems to be necessary to guarantee sufficient iodine supply.

Adolescent↗
PubMed1985

[Sonographic findings in autonomous adenoma of the thyroid gland in a goiter-endemic region].

Ultrasound scanning was carried out in 84 patients with autonomous nodules and 67 patients with inactive nodules. The echo pattern was correlated to the macro- and microscopic findings as well as to the function of the nodules. The autonomous nodules showed a low echogenicity in 57%, a normal parenchyma-identical echogenicity in 10% and a high echogenicity in 33%. In comparison the echo pattern of the inactive nodules showed low level echoes in 31%, normal in 36% and a high level echoes in 31%. Only one third of the nodules showed a homogeneous echo pattern, one third showed liquid degeneration and one third a mixed echo pattern. There is no correlation between the echo pattern of the autonomous nodules and the metabolic function of the nodules. 65 patients have been operated (37 autonomous and 28 inactive nodules). The macroscopic findings showed bleeding and cysts in most of the echo-poor nodules, also those with homogeneous structures. In the histological findings microfollicular structures were found in both high- and low-echogenicity nodules (18/16%). Macrofollicular changes and mixed forms were found mainly in nodules with parenchyma-identical and high echogenicity (58/48%). Ultrasound is very helpful in the morphological diagnosis of thyroid nodules, but there is no significant correlation to metabolic activity or to microscopic structures of the nodules in the thyroid gland.

Adenoma↗
PubMed1978

[Serum concentrations of thyroid hormones in severe non-thyroidal illnesses (author's transl)].

Pathologically low serum total triiodothyronine (T3) concentrations are a characteristic finding in patients with severe non-thyroidal illnesses. No adequate explanation has yet been offered for this phenomenon. We have, therefore, investigated the serum concentrations of total thyroxine (T4), total T3 and total 3,3',5'-triiodothyronine (reverse T3)--the metabolically-inactive metabolite of thyroxine--and of TSH in 13 patients with acute myocardial infarction, in 12 patients with compensated liver cirrhosis, in 9 patients with decompensated liver cirrhosis and in 15 patients with chronic renal failure on chronic intermittent haemodialysis by radioimmunoassay. The values obtained were compared to corresponding values of a normal control group (n - 23). According to our results the decrease in serum T3 combined with normal T4 concentrations in severe non-thyroidal illnesses seems to be a consequence of an alteration in thyroxine degradation. Two different possibilities of alteration can be considered: 1. inhibition of the overall deiodinationof T4, leading to low total T3 serum concentrations with concomitant normal to low reverse T3 serum concentrations (chronic uraemia), 2. a shift in the monodeiodination of T4 towards enhanced reverse T3 production, leading also to low total T3 concentrations, but with a concomitant increase in reverse T3 serum concentrations (myocardial infarction, liver cirrhosis). The results obtained in our patients with liver cirrhosis show, moreover, that this alteration of T4 metabolism depends on the severity of the illness.

Humans↗
PubMed1977

[Determination of pregnancy duration following terminated hormonal contraception].

The duration of pregnancy as assessed by the rule of Naegele was significant different between patients who became pregnant following termination of oral contraception and patients, who had not taken oral contraceptives. The intervall between stopping the pill and pregnancy was two month. We found a relatively high pregnancy rate in the first three month. The clinical significance is discussed.

Contraception↗
PubMed1977

[Screening for hypothyroidism in the newborn with a total T 4-RIA method (author's transl)].

A screening method for detection of congenital hypothyroidism is presented in detail in cooperation with the "Austrian Program for Inborn Errors of Metabolism". Screening is performed by measuring the total T4-content of 1/8 inch filter paper dots filled with dried blood of newborns. The strategy for recall of newborns with borderline or pathological T4-values used, results in a definite diagnosis on day 55 of life. The advantages of additional TSH determination in the filter paper dots are discussed. So far (Sept. 1976) 8645 newborns have been investigated, covering the regions of Vienna and Carinthia (Austria). Preliminary studies reveal a slight dependency of the measured T4-values on the day of sampling. Two congenitally hypothyroid children have been diagnosed so far, corresponding fairly well with the reported frequency in the literature (1 : 6000).

Humans↗
PubMed1976

Infrared dichroism of the DNA-caffeine complex. A new method for determination of the ligand orientation.

Infrared linear dichroism (LD) measurements on films of the DNA-caffeine complex in terms of the relative humidity (r.h.) show two main effects. Firstly, there is an insertion of caffeine molecules into the DNA double helix (B form), as evidenced by a very strong parallel LD behaviour of the 745 cm-1 band due to the C-H out-of-plane deformation vibration of caffeine. Furthermore, a high r.h. values a modified B form occurs in the complex similar to the B form recently reported by BRAHMS and coworkers for DNA-polypeptide complexes. The reversible B-A transition of the DNA in dependence of the r.h. is not affected in general in the presence of caffeine.

Animals↗