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Biomedical subjects

H Fritzsche

Publications and source records attributed to H Fritzsche.

At least 109 records · Page 6Linked to original sources
PubMed1976

Infrared dichroism of the DNA-caffeine complex. A new method for determination of the ligand orientation.

Infrared linear dichroism (LD) measurements on films of the DNA-caffeine complex in terms of the relative humidity (r.h.) show two main effects. Firstly, there is an insertion of caffeine molecules into the DNA double helix (B form), as evidenced by a very strong parallel LD behaviour of the 745 cm-1 band due to the C-H out-of-plane deformation vibration of caffeine. Furthermore, a high r.h. values a modified B form occurs in the complex similar to the B form recently reported by BRAHMS and coworkers for DNA-polypeptide complexes. The reversible B-A transition of the DNA in dependence of the r.h. is not affected in general in the presence of caffeine.

Animals↗
PubMed1976

Influence of diftalone on tolbutamide test and i.v. glucose tolerance test.

In 16 healthy volunteers tolbutamide tests or i.v. glucose tolerance tests were performed with and without previous oral administration of 1000 mg diftalone. Blood sugar and serum insulin were assayed in regular intervals. Both with and without previous administration of diftalone blood glucose after tolbutamide did not show any difference. IRI response to tolbutamide, measured by planimetrical integration showed a statistically significant augmentation (0.05 greater than p greater than 0.01) after diftalone. Glucose assimilation (K-value) after diftalone was decreased (0.05 greater than p greater than 0.01) yet within normal range. For the accompanying insulin levels however no statistically significant difference was observed. In addition a normalisation of pathological tolbutamide test after diftalone could be noted in five patients with subclinical diabetes. Our results indicate that diftalone seems to have the following three actions: 1. Enhancement of the tolbutamide action. 2. direct augmentation of IRI secretion, 3. a peripheral action on glucose metabolism.

Adult↗
PubMed1975

[Electroencephalographic findings in electronically monitored risk births].

Electroencephalograms showed - in accordance with many authors - important statements of perinatal damage and of her prognosis. The fetal monitoring (electronical and gasanalytical) is able to acknowledge in due time a hypoxic situation and procures favourable to the perinatal morbidity. Gross-pathological electroencephalograms we found in 5% of monitored high-risk babies in contrast to 17% of no monitored intrauterine patients.

Electroencephalography↗