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H Fukukita

Publications and source records attributed to H Fukukita.

15 recordsLinked to original sources
PubMed2000

Pilot study on sentinel node biopsy in breast cancer.

BACKGROUND AND OBJECTIVES: Sentinel node biopsy (SNB) in breast cancer using indigo carmine was started in January 1998, and this method has proved feasible and reliable. From our initial experience, sentinel lymph nodes (SLNs) were identified in 65 of 88 cases of breast cancer (74%). METHODS: Lymphatic mapping in breast cancer was assessed using radionuclide, technetium-99m human serum albumin or technetium-99m tin colloid. A pilot study on SNB with dye or a combined method was performed between August 1998 and January 1999. RESULTS: SLNs were identified in 55 of 59 cases (93%). False-negative SLNs were found in 2 cases. The sensitivity and accuracy in all cases were 92% and 96%. SLNs in 52 cases were also diagnosed by immediate frozen sectioning. The sensitivity and accuracy were 89% and 96%. CONCLUSIONS: SNB in the combined method was the best way to identify SLNs in breast cancer.

Axilla↗
PubMed1999

Mammary lymphoscintigraphy with various radiopharmaceuticals in breast cancer.

Sentinel node biopsy (SNB) in breast cancer is a promising surgical technique that avoids unnecessary axillary lymph node dissection. To optimize lymphatic mapping with radiopharmaceuticals, mammary lymphoscintigraphy with 30-50 MBq of technetium-99m-diethylenetriamine pentaacetic acid human serum albumin (99mTc-HSAD), technetium-99m-human serum albumin (99mTc-HSA), or technetium-99m-tin colloid (99mTc-TC) were investigated in 69 cases of primary breast cancer. Dynamic early images were obtained during the first 30 or 40 minutes, and static delayed images were obtained 6 hours after tracer injection. Hot spots as sentinel lymph nodes (SLNs) appeared in 51 of 69 cases (74%): in early images in 27 cases and in delayed images in 24 cases. SLNs were visualized more frequently in 23 of the 26 cases (88%) treated with 99mTc-HSAD and in 21 of the 24 cases (88%) treated with 99mTc-HSA than in only 7 of the 19 cases (37%) treated with 99mTc-TC. In 26 of the 51 cases, SLNs were identified as faint spots in delayed images. There was a significant difference in the first appearance of SLNs on the lymphoscintiscan between 43 cases of dense breast parenchyma and 26 cases of fatty breast parenchyma. These results suggest that 99mTc-HSAD or 99mTc-HSA is acceptable for lymphatic mapping, but in cases which have faint spots in delayed images or fatty breast parenchyma, gamma probe-guided SNB may result in failure or misleading false-negative SLNs.

Adult↗
PubMed1989

[Radioimmunoimaging of malignant melanoma with In-111-labeled monoclonal antibodies 96.5 and ZME 018].

This paper includes the results of imaging and kinetic studies on two kinds of In-111-labeled monoclonal antibodies (MoAbs), 96.5 and ZME 018, which are known to have capability of recognizing different surface antigens present in malignant melanoma cells. These MoAbs were supplied by Hybritech Inc. through Teijin Ltd. The former MoAb (96.5) was used on 11 cases of malignant melanoma and one case of basal cell carcinoma, and the latter MoAb (ZME 018) was used on 6 cases of malignant melanoma and one case of basal cell carcinoma. As for the malignant melanoma, the results obtained from both patients groups were compared to each other. Twenty-four out of 31 lesions in the former group and 9 (including 2 occult lesions) out of 10 lesions in the latter group were visualized. However, these positive ratios can not be compared to each other because of the very small number of the lesions in the latter group. One basal cell carcinoma each from both groups were faintly visualized. Distribution patterns of these In-111-labeled MoAbs were similar to each other. Except for the first two cases in the former group, labeling efficiencies were 94.3 +/- 0.7% with 96.5 and 92.0 +/- 0.6% with ZME 018. Urinary excretions on the 1st day were 8.3 +/- 0.9% with the former and 9.3 +/- 0.3% with the latter. However, there was no statistical difference. Following the 1st day, these values changed at the level of several per cent from the 2nd to 4th day, showing a subtle and gradual rise and slightly lower values for In-111-ZME 018. But, again, there were no statistical differences. Whole body retention curves in both groups were similar to each other, and blood clearance curves were also found similar in both groups. HAMA titers were checked in all patients and were found elevated after the administration in most of the cases. Although the number of patients tested in this series is small, especially with In-111-ZME 018, both MoAbs labeled with In-111 seem to be equally capable of visualizing malignant melanoma. Possibility of the treatment of malignant melanoma with this kind of technique was also discussed.

Adult↗
PubMed1986

Experimental study on the collimator for increasing the resolution of N-isopropyl-p-(123I)iodoamphetamine (IMP) SPECT imaging of the brain.

This study was carried out to design a new collimator for the present 123I-IMP SPECT imaging of the brain, which is hindered by the contamination of 124I and 126I. In this study we intended to increase spacial resolution along the transaxial direction and, at the same time, to compensate for the decrease of sensitivity by sacrificing the resolution along the axial direction to some extent. For this purpose, we developed 4 kinds of slat type units; ultrahigh resolution (UHR), high resolution (HR), high sensitivity (HS), and ultrahigh sensitivity (UHS). In practice, either UHR or HR is set to the detector together with either HS or UHS. After testing 4 kinds of combinations, we found that the combination of UHR-HS gave us far better images than those obtained with the conventional medium energy parallel hole collimator and was best suited for 123I-IMP SPECT imaging of the brain at present. We are now thinking of fusing these two units together into one collimator.

Amphetamines↗
PubMed1982

Clinical evaluation of single photon emission computed tomography of the brain.

Single photon emission computed tomography (ECT) was performed on 67 patients. ECT images were taken with a Shimadzu scintillation camera, LFOV-E, before a delayed scan. Eighteen of 67 patients showed abnormal findings on the ECT images. Fourteen of the 18 had a transmission X-ray CT (TCT) study as well. There were eleven cases with brain metastasis, and a surgical wound. Eleven of forty-nine ECT-negative patients had a TCT study as well, and intracranial lesions were found in five. The smallest lesion found by ECT was 0.5 cm in diameter on the TCT image and the largest lesion missed by ECT was a tumor in the corpus callosum, measuring 4.2 X 2.7 cm. As far as the patients who also received TCT study are concerned, both the ECT and the ordinary scan were thought to be equal in sixteen patients and ECT to be superior in seven whereas the ordinary scintigram was superior in two. At present, ECT is considered to be useful when it is used in addition to the ordinary scans. In the field of clinical nuclear medicine, the development of new radiopharmaceuticals which are labeled with single photon emitters and which can show the metabolic activity of the brain is eagerly awaited.

Adult↗
PubMed1982

A combined method of scintigram and echogram as a trial of integrated image diagnosis.

We developed a method which combines a scintigram and echogram(s) on the basis of precise positional correlation. In our method, an ordinary scintillation camera (Ohio Nuclear sigma 410S) and an ultrasound diagnosis equipment (Aloka Echo Camera) are used, both of which are connected through the interface made by us. This method presents a scintigram with dotted lines through which echograms have been taken, giving us more detailed inside information which we can not obtain from scintigram only. Also obtained are positional correlations between the organ of interest and its neighbouring organs. This method is easily applicable to ordinary scintillation cameras and is useful for our daily practice.

Aged↗
PubMed1981

[Basic studies on radionuclide computed tomography using a rotating chair (author's transl)].

Radionuclide Computed Tomography (RCT) was studied from the technical standpoint of view. In this study, a gamma camera (Ohio Nuclear sigma 410S) and a rotating chair designed by one of us were used. The computer used was Scintipac 1200 (32 kW memories and 2.4 MB X 2 disk memories). A cylindrical phantom having a diameter of 20 cm was also designed by us into which various-sized tubes could be inserted for resolution study. The phantom was set on the chair, the center of which was 20 cm off from the surface of the detector. The chair was rotated manually 10 degrees, and finally 36 digital images in the form of 64 X 64 elements were obtained, covering an entire circumference. RCT images were displayed in the form of 128 X 128 elements on a X-ray film through a Microdot Imager. At first, the phantom was filled with 99mTc solution and the uniformity of the RCT image on it was checked using several formulae for count rate correction to find out which one of the formulae was best fitted. For the reconstruction of the RCT image, "filtered back projection" was used. Then, we found that, as far as out phantom study was concerned, simple geometrical mean on the data from the two opposing directions was found the best for the count rate corrections, which was exclusively used thereafter. The fluctuation on the uniform source was found to be approximately 15%. For the resolution study, hot tubes having diameters of 1.0, 2.0, 3.0, and 4.0 cm and cold tubes of 1.5, 2.4, 3.5, and 4.7 cm were inserted into the phantom. As for the hot tubes, all the tubes were depicted on the RCT image whereas 2.4 cm was the smallest depicted for the cold tubes. FWHM was checked with a fine line source in the phantom and was found to be 2.0 cm regardless to its depth. The Alderson liver phantom was also used to detect defects in the air and it was found both balls having diameters of 2.7 and 3.7 cm could be depicted on the RCT image. Now we are evaluating clinical usefulness of this technique on the liver. The results will be published in the near future.

Evaluation Studies as Topic↗
PubMed1980

[Gamma dose estimation to the gastric wall after administration of a capsule containing a large dose of 131I (author's transl)].

Gamma dose to the gastric wall from a capsule containing 1.85 GBq (50 mCi) of 131I was estimated in 6 patients who had received total thyroidectomy for thyroid carcinoma some years before. The tests were done with a 37 MBq (1 mCi) capsule each in 5 patiens and with a 185 MBq (5 mCi) capsule in one patient. All the patients were requested to fast in the morning. The capsule was given with a glass of water (200 ml). Then, the patient kept supine position under the scintillation camera for a period of one hour except one patient on whom the test was suspended at 30 minutes because of early clearance of the radioactivity from the stomach. In one of 5 patients who were tested for a period of one hour, serial scinticamera images showed almost no movement and minimum dissolution of the capsule. The remaining 4 patients showed slight to moderate movements of the capsules with a variety of dissolution speeds. Data processings were done by Scintipac-1200. The estimated doses at the distance of 0.5 cm from the source were 3.820, 2.074, 1.445, 1.154 and 1.462 grays (382.0, 207.4, 144.5, 115.4 and 146.2 rads) per initial one hour and 375 mGy (37.5 rad) per initial 30 minutes, respectively. From these data, it is thought to be wise to advise the patient to rotate or shake the body on bed occasionally after swallowing the capsules containing a large dose of 131I for the treatment of thyroid cancer. It is also desirable to recommend the patient to walk around even though the controlled patient's room is small. Additional water may be also meaningful to avoid unnecessary irradiation to the gastric wall.

Adult↗
PubMed1980

Subtraction scintigraphy with 67Ga-citrate and 99mTc-colloid in the diagnosis of intrahepatic masses.

Subtraction scintigraphy of the liver with 67Ga-citrate and 99mTc-colloid (99mTc-phytate) was performed by subtracting the image of the latter from the image of the former in 34 patients who were suspected of having intrahepatic masses, especially hepatoma. The computer used was Scintipac 1200 (32 KW memories and 2.4MBX2 disk memories). Both images were taken in a digital form (128 X 128 elements). After normalizing both images, 4 different factors (0.6, 0.8, 1.0, and 1.2) were applied to the 99mTc image before the subtraction from the 67Ga image. We found that this technique was very useful for the detection of abnormal 67Ga accumulation in the liver.

Adult↗