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Biomedical subjects

H Fusamoto

Publications and source records attributed to H Fusamoto.

At least 199 records · Page 11Linked to original sources
PubMed1983

Gastric mucosal blood distribution and its changes in the healing process of gastric ulcer.

Changes in gastric mucosal blood volume in the healing process of ulcers were investigated by organ reflectance spectrophotometry performed during endoscopy. Spectra were taken from 24 regions in the stomach in 42 patients with gastric ulcers located at the angle of the stomach. Fifty-one patients with no gastric lesions were used as normal controls. In patients with active gastric ulcers, mucosal blood volume decreased significantly in most regions in the stomach. During the healing process, mucosal blood volume returned to the same levels as those of the controls. On the other hand, mucosal blood volume around the gastric ulcer increased significantly as compared with that of surrounding mucosal at the healing stage. The rise in mucosal blood volume of the ulcer margin at the healing stage (H2 stage) was 33% in cases where gastric ulcers healed within 3 mo, and 2% in cases where the gastric ulcer failed to heal after 3 mo of therapy. It was concluded that the mucosal blood volume changes during the healing process of gastric ulcer and that an increased blood supply to the ulcer margin at the healing stage has a strong effect on the healing periods of ulcer. The reduction of mucosal blood volume at the active stage of the ulcer may also be implicated in the pathogenesis of gastric ulcers.

Adult↗
PubMed1982

Gastric mucosal hemodynamics after thermal or head injury. A clinical application of reflectance spectrophotometry.

In order to elucidate the role of mucosal blood flow in stress ulceration in critically ill patients with thermal or head injury, we applied reflectance spectrophotometry to the human gastric mucosa. During gastrofiberscopy, the spectra of the corpus and antral gastric mucosa were taken using a flexible coaxial optic bundle and a computer-equipped spectrophotometer. The subjects were 27 patients with thermal or head injury, and they were compared with 8 young healthy volunteers and 9 age-matched patients who had GI symptoms but showed no gastric lesion endoscopically. In 8 patients whose gastric mucosal blood volume at the time of admission decreased to about 27% of the level of young healthy volunteers or 36% of that of age-matched controls, the acute gastric mucosal lesions appeared in the corpus mucosa mostly within a few days after the measurement of mucosal blood volume. In contrast, in cases with thermal or head injury and without acute gastric mucosal lesions, the mucosal blood volume did not decrease significantly as compared with that of the young healthy volunteers and age-matched controls. In conclusion, analysis of mucosal has revealed that ischemia in the gastric mucosa is the main cause of the acute gastric mucosal lesions in patients with thermal or head injury. Further, this study represented noninvasive methodology for the measurement of the gastric mucosal blood volume in patients with gastric diseases.

Adult↗
PubMed1980

Computerised tomography as an indication of long-term outcome after acute carbon monoxide poisoning.

21 patients with acute carbon-monoxide poisoning had repeated brain scans by computerised tomography (CT) between May, 1977 and June, 1979. On the basis of the initial CT findings, the 21 patients could be divided into two distinct groups. In 11, areas of low density were seen bilaterally in the globus pallidus. These areas were still present 3 months after initial CT. In all but one of these patients the outcome was poor. The remaining 10 had no abnormal findings on their initial brain CT scans; outcome was good in this group.

Acute Disease↗
PubMed1978

[Hyperamylasaemia in patients in shock (author's transl)].

In 69 patients, treated in the intensive care unit of the department of traumatology we have examined the blood amylase activity. We found, that traumatic shock produced an increase in serum-amylase. Hyperamylasaemia is strongly related to the duration of shock and is due to an increase in S-type amylase. The increase is probably caused by an increased production and not by decreased renal excretion. The mechanism of hyperamylasaemia and the source of it are discussed.

Adolescent↗
PubMed1977

Management of patients in shock.

Clinical study was conducted in the course of treatment of patients with hypovolemic and septic shock at Department of Traumatology, Osaka University Hospital. We have found large difference between data obtained in our study and experimental results obtained in animals. In hypovolemic shock of man, we could not observe "taking up phenomenon" to abdominal organs. Therefore, if the shock does not respond to transfusion and infusion, we must look for other causes. In patients whose shock state persisted more than 10 hours, death related to shock organs increased remarkably. The nature of septic shock in man is hyperdynamic state. Hemodynamic change during the development of septic shock from sepsis was described and the difference from experimental research on endotoxin shock in animals was discussed.

Adult↗
PubMed1977

Gastrointestinal bleeding following head injury: a clinical study of 433 cases.

The incidence of gastrointestinal bleeding was studied in 433 patients with head injury. This complication has a strong correlation to the severity of the injury. Other factors such as shock, arterial pO2 and glucocorticoid administration were not related to incidence of gastrointestinal bleeding. Forty per cent of patients developed bleeding within 48 hours and approximately and additional 40% within one week. Only nine patients required more than 1,000 ml of blood, and eight of these died and one requiring emergency abdominal surgery lived.

Adolescent↗
PubMed1977

Acute gastroduodenal lesions in head injury. An endoscopic study.

Early and serial endoscopic examinations were performed in patients with head injury to determine the actual incidence and course of the acute gastroduodenal lesions. Acute gastroduodenal lesions were found in high incidence of 35 in 47 patients (75%). It was stressed that the lesions were found in 16 of 25 cases without obvious gastrointestinal bleeding. The lesions were mainly found in the stomach (78%) and of these lesions erosive gastritis was seen in the greatest frequency. Gastric ulcer was found in 11 patients. Erosive gastritis was found within one week after the trauma, while gastric ulcer usually developed after one week. Erosive gastritis was mainly located in the body of the stomach and usually healed within ten days. Gastric ulcer also had a good course. There was no case in which the erosive lesion extended to the ulcer. Among 22 patients with gastrointestinal bleeding, three had intractable bleeding. Steroid administration seemed to have little effect on the occurrence of acute gastroduodenal lesions.

Adolescent↗
PubMed1976

Endoscopic observation of the gastric mucus in vivo stained with azure A.

Gastric mucus was stained with Azure A, a cationic dye, which had the highest affinity with macromolecular constituents of the mucus, under such conditions as 0.2% Azure A-0.5% NaHCO3 solution (pH 8.1) in dye concentration, staining for ten minutes, 37 degrees C in reaction temperature and the salt concentration and ionic strength below 6.0 x 10(-2). In rat and resected human stomachs, gastric mucus was clearly stained under these conditions. In human subjects, the in vivo stained muscu was observed endoscopically. The pyloric gland region. The difference was seen in the pattern of the gastric area between the fundic and pyloric gland region. Histological examination revealed that only the mucous layer was stained with Azure A. The stained macromolecules in the mucus and factors affecting the staining were discussed.

Adolescent↗