Biomedical subjects

H Futami

Publications and source records attributed to H Futami.

57 records · Page 4Linked to original sources

PubMed1985

Phase II study of 7-N-(p-hydroxyphenyl)-mitomycin C (KW2083) in patients with advanced non-small cell carcinoma of the lung and metastatic pulmonary tumors.

Twenty-six patients with non-small cell carcinoma of the lung and 25 with metastatic pulmonary tumors were treated by intravenous injection of 7-N-(p-hydroxyphenyl)-mitomycin C (KW2083), a derivative of mitomycin C, either at a single 70-mg/m2 dose or at a dose of 20-30 mg/m2 once a week for 3 weeks. Two patients with adenocarcinoma among 21 evaluable patients with non-small cell carcinoma of the lung, and one with embryonal cell carcinoma among 21 patients with metastatic pulmonary tumors achieved partial response lasting 5 to 7 weeks. In these three patients, KW2083 was administered by a single 70-mg/m2 dose, and no patients who received a dose of 20-30 mg/m2 weekly achieved objective response. Myelosuppression, primarily thrombocytopenia, was pronounced with either treatment regimen and it was the major dose-limiting toxicity.

Adult↗

PubMed1985

Preliminary phase II study of adriamycin (ADM) in patients with non-small cell lung cancer (NSCLC).

A phase II study of adriamycin (ADM) (60 mg/m2) was performed in 22 patients with non-small cell lung carcinoma (NSCLC). There were no responders in the 19 evaluable patients (16 with adenocarcinoma, two with squamous cell carcinoma and one with large cell carcinoma). The major side effects were alopecia (89%), leukocytopenia (73%), thrombocytopenia (58%) and upper gastrointestinal symptoms. Although ADM at 60 mg/m2 did not appear to have sufficient antitumor activity against NSCLC in this study, it is necessary to evaluate further the efficacy of ADM against NSCLC with another treatment schedule.

Adenocarcinoma↗

PubMedDate not supplied

A case of AFP-producing early gastric carcinoma with rapid growth liver metastasis.

An 84-year-old man presented with complaints of epigastric discomfort. Upper gastrointestinal series and endoscopy showed an elevated lesion at the posterior wall of greater curvature on the gastric fundus. Diagnosed as moderately differentiated tubular adenocarcinoma by biopsy, wedge resection and 4sa regional lymph node dissection were carried out. The tumor morphology showed type I with slight elevation, 2.5 x 1.7 cm in size; histological showed papillary, tubular, and solid formations having clear cytoplasm and large bizarre nuclei invading the deep submucosal layer (sm2). This case was evaluated as T1(sm) N0 M0 stage Ia early gastric cancer. In the 5th month after operation, multiple liver metastases were detected. He died of liver failure by rapid growth of metastatic tumors in the 6th month after operation. The serum alpha-fetoprotein level at recurrence was 1,900 ng/mL, and alpha-fetoprotein-positive cells were immunohistochemically detected in operative and liver biopsy specimens.

Aged↗