Biomedical subjects
H G Close
Publications and source records attributed to H G Close.
Buccal smears and numerical sex chromosome anomalies.
The results of buccal smear examinations of patients in five institutes for mental retardates, a psychiatric hospital, a home for physically handicapped children, two schools for the deaf, a normal primary school and a newborn nursery are reported. Extra X chromosomes were found in 4/1 000 mentally retarded males, in 1,8/1 000 mentally ill patients and in 1,3/1 000 newborn females. Extra Y chromosomes were found in 1,5/1 000 males, and 3,6/1 000 males were noted to have non-fluorescing Y chromosomes, a normal variant.
Down's syndrome with additional XYY aneuploidy.
A further case of Down's syndrome with additional XYY aneuploidy is reported. The child has been followed for 5 years. It has not been possible to recognise any phenotypical feature which distinguishes the patient from others with Down's syndrome.
The incidence of sex chromosomal abnormalities in mentally subnormal males.
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Chloride and water in the constitution of tissues.
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Variations in some of the constituents of the blood throughout the menstrual cycle in normal women.
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