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Biomedical subjects

H G French

Publications and source records attributed to H G French.

8 recordsLinked to original sources
PubMed1985

Chronic atlanto-axial instability in Down syndrome.

We studied the radiographs of thirty-two patients with Down syndrome for evidence of atlanto-axial instability. One of the patients had instability in 1970 and seven had it in 1983. The interval between the atlas and the odontoid process in the patients who demonstrated motion at that interval radiographically averaged 2.78 millimeters in 1970 and 6.93 millimeters in 1983 (p less than 0.005). Four patients whose radiographs showed atlanto-axial motion in 1970 lost that motion by 1983, and in seven patients who did not show atlanto-axial instability in 1970 it developed by 1983. Atlanto-axial instability was more likely to develop in boys who were more than ten years old. Accessory upper-cervical ossicles became evident in three patients, none of whom had atlanto-axial motion. However, one of these three patients had an abnormally wide atlanto-axial interval.

Age Factors↗
PubMed1984

Correlation of tissue reaction to corrosion in osteosynthetic devices.

This study evaluated the interaction of osteosynthetic plates to adjacent tissue. Eleven patients had 13 plates removed with simultaneous biopsies of the adjacent soft tissue. Four patients had pain localized to the area of the plate and 11 patients had routine removal or removal for fracture nonunion. Each plate was graded on a 0-5 point scale for the amount and severity of corrosion present at the screw-plate interface. The adjacent tissue was fixed in formalin and stained with hematoxylin and eosin. The tissue reaction was graded on a 0-5 point scale based on the inflammatory response. A positive correlation of corrosion and tissue reaction was found that was significant at p less than 0.005 in the asymptomatic group. The other good correlation showed that tissue reaction tends to decrease with time at p less than 0.005. There was no correlation of corrosion with tissue reaction in the symptomatic removal group. All patients with pain adjacent to the plates were relieved by implant removal. The findings suggest that stainless steel is minimally toxic to human tissue in most circumstances and that the toxic products are well tolerated. There was a significant group (4/11) that showed a different pattern of tissue response which did not appear to be toxic response. We do not recommend routine implant removal to prevent metal toxicity; however, there is a group of patients who have pain in the area of the implant that may be caused by an allergic reaction and is relieved by implant removal.

Adolescent↗
PubMed1984

Tissue reaction to a failed Bion hip prosthesis in a dog.

The tissue reaction in a dog to a failed constrained total hip replacement system with a Bion elastomer component was evaluated. The device consisted of Ti-6A1-4V alloy acetabular and femoral components connected with a Bion component. At necropsy the Bion component was found to have fractured. The tissue surrounding the Bion was granulomatous with numerous blackened regions. Histologically a severe chronic inflammatory response was present in the surrounding tissue with numerous giant cells and Bion laden macrophages.

Alkadienes↗
PubMedDate not supplied

A histologic and mechanical evaluation of carbon-coated polyester suture.

Ultra low temperature isotropic (ULTI) carbon-coated polyester suture material was evaluated histologically and mechanically in dogs. These results were compared to those obtained for uncoated polyester and polybutylate coated polyester. The suture materials were used in the repair of the surgically incised medial collateral ligament and subcutaneous tissues to evaluate the potential of the carbon-coated system for ligamentous repairs. Following surgery, the dogs were sacrificed at periods of 1-48 weeks postoperatively for evaluation of tissue biocompatibility and mechanical strength of the materials. The polybutylate-coated polyester suture broke at lower force levels than did comparable sizes of uncoated or carbon-coated polyester. All three types showed a high retention (greater than 98%) of mechanical strength at 48 weeks, often exhibiting an increase in tensile strength due to tissue ingrowth. The histologic response to carbon-coated polyester was equal to or better than the response to either the uncoated polyester or polybutylate-coated polyester. A greater degree of tissue growth into the carbon-coated material was evident at most time periods following an initial acute inflammatory response which was also present in the other materials.

Animals↗
PubMedDate not supplied

Upper cervical ossicles in Down syndrome.

Six patients with upper cervical spine ossicles and Down syndrome from a study population of 184 are described. The average age was 20.6 years at the time of diagnosis. Three of the patients were involved in tumbling. Radiographic anatomy of the ossicles and the dens, as well as serial radiographs in three of the six patients, suggest that this represents an avulsion of the upper end of the dens rather than an occipital vertebrae, ossiculum terminale, or os odontoideum, as previously described. The authors advocate restriction of high-risk activities for all patients with Down syndrome.

Adolescent↗
PubMedDate not supplied

Open reduction and internal fixation of comminuted radial head fractures.

Between November 1981 and November 1984, eight patients with comminuted radial head fractures were treated with open reduction and internal fixation. The recommended treatment for these fractures has been early motion, with or without radial head excision. According to the AO classification all were B3-1 or B3-2 fractures. All fractures were fixed through Kocher incisions using Kirschner wires and AO small fragment screws. All patients began motion 7 to 10 days following surgery. In a retrospective study, clinical results were reviewed in six patients with an average followup of 12 months (range, 4 to 40 months). Three patients had associated elbow dislocations, one requiring internal fixation of the coronoid process. Loss of range of motion averaged 3 degrees of flexion, 10 degrees of extension, 3 degrees of pronation, and 20 degrees of supination. Cybex testing demonstrated no significant difference in strength between injured and uninjured extremities. The only complication was a transient posterior interosseous nerve palsy. No patient had evidence of any radial shortening. Our findings suggest that open reduction and internal fixation gives satisfactory elbow function and avoids complications of radial shortening, loss of motion, and wrist symptoms that may subsequently occur following radial head excision.

Adult↗