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Biomedical subjects

H G Kohler

Publications and source records attributed to H G Kohler.

5 recordsLinked to original sources
PubMed1978

Low thymic weight in small-for-dates babies.

The thymic weights of 20 growth-retarded babies dying at or about birth were found to be less than normal for their birth weights. It is suggested that small-for-dates babies that survive may be immunodeficient as are children who suffer from extrauterine malnutrition.

Birth Weight↗
PubMed1978

Premature closure of the ductus arteriosus (P.C.D.A.): a possible cause of intrauterine circulatory failure.

In the course of some 800 perinatal necropsies (corresponding to approximately 26,000 deliveries), 3 stillborn infants were found to have an almost completely closed ductus arteriosus. Each of these showed cardiomegaly, dilatation of right-side chambers, pulmonary hyperaemia and oedema of varying degree and extent; intrauterine death was considered to be due to P.C.D.A. In several further cases the ductus was also narrowed but not necessarily responsible for intrauterine death. This frequency suggests that P.C.D.A. is more common than might be surmised from very scanty documentation in the literature. Possible aetiological factors of P.C.D.A. as well as its effects on the circulation are briefly discussed.

Blood Circulation↗
PubMed1978

Meckel's syndrome (dysencephalia splanchno-cystica) in two Pakistani sibs.

A Pakistani couple, who were first cousins once removed through their fathers, and whose mothers were also related, had two liveborn children, a boy and a girl. Both children died within 2 hours of birth with occipital encephalocele, microcephaly, polycystic kidneys, and cystic distension of intrahepatic bile ducts. Both children had normal karyotypes. These abnormalities constitute Meckel's syndrome (dysencephalia splanchno-cystica); this is the fifth report of parental consanguinity, adding further support to the evidence for autosomal recessive inheritance of the disorder.

Consanguinity↗