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Biomedical subjects

H G Laberke

Publications and source records attributed to H G Laberke.

30 records · Page 2Linked to original sources
PubMed1983

A contribution to the morphology and pathogenesis of thyroid-like lesions in the kidney.

The morphological variations of thyroid-like lesions in the kidney in 15 cases with chronic destructive interstitial nephritis as the basic alteration were examined with light microscopy and immunohistological methods. Reflux pyelonephritis was present in some cases. Thyroid-like lesions can develop at any age. "Mature" thyroid-like lesions possess large follicular structures and solid tubular epithelial cell complexes, whereas the follicular structures in "young" thyroid-like lesions are small. The hyaline casts are Tamm-Horsfall protein positive in between one- and two-thirds of the follicles. IgA is present in all follicular lumina. The thyroid-like lesions are the result of a regenerative process. They develop after subtotal parenchymal destruction of remaining tubular epithelial cells from the ascending limb of the loop of Henle, the distal convoluted tubules and the collecting ducts. They are pathognomonic for healed destructive bacterial interstitial nephritis, but can also be observed in analgesic nephropathy, hydronephrosis, and nephronophthisis when these basic diseases are preceded by pyelonephritis.

Adolescent↗
PubMed1983

[Traumatic bladder perforation in pelvic ring fracture. Case report with differential diagnostic aspects].

In the context to multiple traumata, a 19-year-old man suffered an extraperitoneal bladder rupture due to perforation by a fractured pubic ramus. Because of a rapid shock-induced decrease of hematuria and the misinterpretation of a bruise on the right flank as a renal contusion, the clinical diagnosis was not established. The patient died of head injuries and ruptures of the liver and diaphragm with hemothorax and intra-abdominal bleeding. The impressive bladder perforation was first documented at the postmortem examination. The diagnosis and differential diagnosis of hematuria are discussed.

Adult↗
PubMed1982

Juxtaglomerular apparatus of the human kidney: correlation between structure and function.

Electron microscopic and morphometric evaluation of the juxtaglomerular apparatus (JGA) of the human kidney showed the following: (1) The JGA of the human kidney consists of the epithelioid cells of afferent and efferent arterioles, the Goormaghtigh cells, and the macula densa, and it is abundantly supplied with sympathetic nerves. (2) The macula densa is in contact with the juxtaglomerular cell complex (JGC), the endocrine part of the JGA, via the Goormaghtigh cell field. The surface area of the macula densa is much larger than is the contact area with the JGA, totalling, in the healthy human kidney, some 66 cm2. (3) The total volume of all JGC's is 26 to 40 mm3. (4) Morphometric investigations of the JGC showed that appropriate stimulation by a decrease in the intrarenal or systemic blood pressure led to hypertrophy and hyperplasia of the JGC, which, in extreme cases, may also lead to a transformation of both the Goormaghtigh cells and mesangium cells into epithelioid cells.

Humans↗
PubMed1981

The possibility of scar formation due to intrarenal reflux in analgesic nephropathy.

Using an autopsy case of a 59-year-old man with analgesic nephropathy, papillary necrosis, and nephrolithiasis, it is shown that analgesic nephropathy may be complicated by damage resulting from intrarenal urine reflux. The morphologic alterations characteristic of intrarenal and/or pyelointerstitial reflux are caused by high intrapelvic pressure values during episodes of renal colic. Bacterially infected and possibly also sterile urine is then forced into the interstitium, directly within the papillary defect or indirectly via the tubular system after rupture of the tubule. The result is a severe interstitial process with inflammation, destruction, and scarring.

Analgesics↗
PubMed1981

[Morphologic substrate in bacterial urinary tract infections (author's transl)].

Bacterial urinary tract infections can lead to acute or chronic, nonspecific or specific lesions of the kidney, renal pelvis, ureter, urinary bladder, and urethra. The inflammatory process may be limited to the kidney and/or to segments of the urinary tract. The most important and frequent pathoanatomic alterations were defined; the microscopic findings were described and supplemented with selected macroscopic and pathogenetic aspects. Juvenile bacterial interstitial nephritis was differentiated from adult bacterial interstitial nephritis on the basis of age-dependent anatomic conditions.

Adult↗
PubMed1980

Treatment of acute interstitial nephritis.

Treatment for acute interstitial nephritis (AIN) was examined in a retrospective study of 27 cases of AIN confirmed by kidney biopsy, and the results were statistically evaluated. The clinically determined serum creatinine values were taken as the criterion. The observation period ranged from 9 months to 2 1/2 years. The prognosis for seven patients who had received steroid preparations in addition to antibiotic and diuretic drugs in the early phases of the disease was significantly better than that of the other 20 patients who had been treated with only antibiotics and diuretics (p less than 0.05). Since the grade of severity of AIN in the two groups was almost identical (determined by maximal serum creatinine values) the two groups could be compared statistically.

Anti-Bacterial Agents↗
PubMed1980

Acute interstitial nephritis: correlations between clinical and morphological findings.

The clinical and morphological findings in 30 cases of acute interstitial nephritis were compared in an attempt to find possible correlations. Patchy and/or incompletely diffuse interstitial infiltration was considered a milder form of the disease, the prognosis of which was significantly better than that of diffuse disease (P less than 0.01, Wilcoxon test). The prognosis was significantly poorer when acute renal failure persisted for three weeks or more (P less than 0.01), Wilcoxon test). Serum creatinine values served as a criterion for evaluating the course and prognosis of the disease. The patients were assigned to one of four prognosis groups.

Acute Disease↗
PubMedDate not supplied

[Fibromatoses in orthopedics--what is certain?].

Based on a cauistic observation, a survey of the rare fibromatoses and desmoid fibromas, respectively, is given from the orthopaedic aspect. Considerable risk factors may be present by incorrect interpretation of these tumors, concerning the differential diagnosis which can be problematic as opposed to harmless fibrosis and highly malignant fibrosarcoma. Thus, a detailed knowledge of these semi-malignant neoplasms is imperative for orthopaedic surgeons, although they will opposite to the more frequent abdominal localizations found in surgical medicine, expect rarely find affected the extremities and the area of the dorsal scapular arch, respectively by fibromatoses.

Bone Neoplasms↗