A CLINICAL AND EXPERIMENTAL STUDY OF THE ELECTROCARDIOGRAPHIC CHANGES IN EXTREME ACIDOSIS AND CARDIAC ARREST.
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Biomedical subjects
Publications and source records attributed to H G MORGAN.
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The techniques and interpretation of acid-base studies on patients undergoing open-heart surgery with extracorporeal circulation are described. The ;normal' range and duration of changes in 35 surviving patients are given; these were essentially of respiratory rather than of metabolic origin, being a respiratory alkalosis induced by the anaesthetist before perfusion, and a respiratory acidosis after assisted respiration was stopped. Gross metabolic acidosis was seen only where clinically severe complications had occurred.
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A patient with primary hyperparathyroidism is described in whom, pre-operatively, the renal tubular handling of phosphate was within the limits accepted by recent writers as normal. The tests they advocate were, therefore, shown to be unreliable in this disease. The hypercalcaemia of primary hyperparathyroidism is one type of hypercalcaemia that is apparently not reduced to normal after the administration of an adequate dosage of cortisone. In our patient, such a "cortisone-fast" finding is documented, and was a valuable aid in the decision to operate.
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