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Biomedical subjects

H G Pegels

Publications and source records attributed to H G Pegels.

4 recordsLinked to original sources
PubMed1986

Vindesine in refractory multiple myeloma.

In 12 of 18 patients with multiple myeloma refractory to treatment with the combination of vincristine, melphalan, cyclophosphamide, and prednisone, favorable results were obtained by replacing vincristine in this combination with vindesine. Although only three patients showed marked reductions (greater than 50%) of myeloma protein, this treatment, which was well tolerated, was also clearly beneficial to the other responding patients, thus postponing the need for more toxic treatment programs.

Adult↗
PubMed1980

Proliferation of T gamma cells with killer-cell activity in two patients with neutropenia and recurrent infections.

Two patients with severe granulocytopenia and recurrent infections of the skin and oropharynx had excess T lymphocytes with receptors for the Fc portion of IgG (T gamma cells) in blood and bone marrow. The abnormal T gamma cells killed antibody-sensitized target cells in vitro (killer-cell activity) but did not suppress immunoglobulin production by B lymphocytes (suppressor-cell activity). T gamma lymphocytes from normal persons showed both killer-cell activity and suppressor-cell activity. In the serum of one patient, granulocyte antibodies, possibly of an autoimmune nature, were detected. The clinical picture in conjunction with the hematologic and immunologic findings characterized the disease of both patients as a distinct entity among the chronic lymphoproliferative diseases of T-cell origin.

Aged↗