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Biomedical subjects

H G Rohner

Publications and source records attributed to H G Rohner.

At least 55 records · Page 3Linked to original sources
PubMed1980

[Cirrhosis of the liver and esophageal bleeding after chronic vitamin A intoxication (author's transl)].

A female patient with congenital ichthyosis took vitamin A in an uncontrolled manner throughout 3 years totalling 60 Mill. IU. This lead to cirrhosis of the liver confirmed histologically after biopsy; vitamin A could be demonstrated in tissue of liver and spleen by fluorescence microscopy. Bleeding from esophageal varices could not be stopped by conventional means, but only by sclerosing the esophageal mucosa in the areas affected. A relapse of bleeding from varices of the fornix was stopped by disconnection according to Hassab-Paquet. The patient died from hepatic failure in advanced hepatic cirrhosis. A long time treatment with high doses of vitamin A seems to be a doubtful therapeutic procedure, especially in view of the fact, that side effects of this therapy cannot be monitored by laboratory measurements; when a disturbed liver function becomes evident, irreversible damage, e.g. cirrhosis or fibrosis and portal hypertension, is already present.

Adult↗
PubMed1980

[Binding capacity of sex hormone binding globulin and corticosteroid binding globulin in serum of male patients with liver cirrhosis (author's transl)].

The binding capacities of SHBG and CBG were measured by agar gel electrophoresis in 63 men with cirrhosis of the liver and in 42 healthy male subjects. The normal range (X- +/- 2s) for SHBG was 8.3-17.1 microgram/l, for CBG 46.4-82.8 micrograms/l. SHBG binding capacity was significantly higher in men with liver cirrhosis (mean 18;1 microgram/l; p less than 0.001) but CBG binding capacity was significantly lower (mean 49.7 microgram/l; p less than 0.001). Although SHBG was lower in patients with decreased CBG binding capacity, a correlation between both steroid binding proteins did not exist. Moreover, there was no correlation between SHBG or CBG on one hand and other parameters of hepatic protein synthesis such as serum protein concentration, cholinesterase activity and the coagulation factors V and VII on the other hand. In contrast to liver cirrhosis, 12 patients with fatty liver and 11 patients with toxic fibrosis of the liver did not reveal changes in SHBG or CBG. Treatment with spironolactone (200 mg daily for one week in 9 subjects) did not change the steroid binding capacity of human serum.

Adult↗
PubMed1980

[Ulcer of the esophagus after intake of emeproniumbromide (author's transl)].

Two female patients were treated because of pollakiuria with emeproniumbromide tablets. They developed extended ulcers of the esophageal mucosa. The tablets had been taken late in the evening with only little fluid. Ulcer formation is thought to be due to prolonged passage time and to a locally damaging effect of the hygroscopic compound. There may be lesions of the esophageal musculature as well, as demonstrated by considerable disturbance of esophageal motility. Ulcers tend to be painfull; they heel fast without formation of scars.

Adult↗
PubMed1980

[Internal findings in mastocytosis].

45 patients with urticaria pigmentosa were thoroughly investigated and a systemic involvement concerning the bone marrow, the skeletal system, liver, spleen, and coagulation was often encountered. This systemization is no sign of malignancy. Benign systemic mastocytosis should be differentiated from malignant mastcell-reticulosis.

Age Factors↗
PubMed1980

[Early cancer and chronic erosions with foveolar hyperplasia of gastric mucosa (author's transl)].

A case report is given of a patient with an early gastric carcinoma (IIa + IIc), who had at the same time chronic erosions, accompanied by a reactive foveolar hyperplasia of the mucosa as could be demonstrated after surgery. A causal relationship of these lesions has not yet been proven, coincidence of the changes seems to be rare as judged from the literature. Nevertheless this case would suggest, that in patients with chronic gastric erosions each lesion should be carefully controlled throughout the course of the disease.

Adenocarcinoma↗
PubMed1979

Cimetidine for anastomotic ulcers after partial gastrectomy. A randomized controlled trial.

In a randomized double-blind multicenter trial, 15 outpatients with endoscopically proved anastomotic ulceration after Billroth I or Billroth II partial gastrectomy received cimetidine, 1 g daily over eight weeks, or a placebo. All patients also received antiacid. The ulcer healed completely in all seven cimetidine-treated patients and in one of the eight placebo-treated patients (P less than 0.01). Ulcers not healed during the double-blind phase of the trial were all subsequently healed on open cimetidine treatment. There was a trend toward improvement of daytime symptoms in favor of cimetidine (P = 0.06), and nighttime symptoms were significantly relieved during the initial four weeks of cimetidine treatment P = 0.02). We conclude that cimetidine, 1 g daily, promotes healing of anastomotic ulcers after partial gastrectomy.

Adult↗
PubMed1978

[Duodenal stenosis in chronic relapsing pancreatitis (author's transl)].

Duodenal stenosis in chronic relapsing pancreatitis occurs in 20% of our patients. In 21 of our cases, the stenosis was always in the descending portion of the duodenum, and in two-thirds it caused an obstruction. The stenosis is always concentric with destruction of the mucosal pattern, widening of the neighbouring folds, irregular contours, and, possibly, straightening of the medial margin of the duodenum. There may be widening of the duodenal loop and frequently the duodenal loop is dilated. The causes for these appearances vary, but a peri-pancreatitis or duodenitis are most frequent. There is no close relationship with the severity of the pancreatitis. Our findings are compared with the small number of reports to be found in the literature.

Adult↗
PubMed1978

[Esophageal manometry in Behçet's disease (author's transl)].

Esophageal function was investigated by quantitative intraluminal pressure measurements in three patients with Behçet's disease. All three had motility disorders partially resembling those described in diabetics and partially those from patients with scleroderma. These motility disturbances may be secondary to a neurological involvement in Behçet's disease.

Behcet Syndrome↗
PubMed1978

[Behçet's disease and the gastrointestinal tract (author's transl)].

Behçet's disease is characterized by the triad of aphteous stomatitis, genital ulcerations and uveitis. This syndrome is thought to be a systemic disease with various unspecific manifestations, which may arise in other organs as well in a considerable number of cases. More than 50% of all patients do have gastrointestinal symptoms; erosive and ulcerative lesions are found primarily in the jejunum and colon. Case reports are given of 3 patients with Behçet's disease and gastrointestinal involvement; one of these patients died. All patients did have unspecific changes of esophageal motility.

Adrenal Cortex Hormones↗
PubMed1978

[Scintigraphic changes on the liver and spleen in urticaria pigmentosa].

In 36 patients with mastocytosis pathological changes in liver and spleen were scintigraphically demonstrated. These changes are due to the histologically proven involvement of the reticuloendothelial system. The infiltration of the liver by mast cells was not evident in liver biopsy.

Adolescent↗
PubMed1978

[The radiological appearances of caustic burns in the upper intestinal tract (author's transl)].

Seventy-nine caustic burns of the upper gastrointestinal tract were divided into early and late effects. The radiological findings were analysed and discussed. The central role of radiology proved to be indisputable, particularly for demonstration of a perforation and for the control of treatment. Endoscopy is of particular value in the diagnosis of caustic burns if the radiological findings are negative, for following treatment and for clarifying atypical late changes.

Burns, Chemical↗
PubMed1977

[Corrosive lesions of the upper intestinal tract in gastrectomized patients (author's transl)].

Lesions of the upper gastrointestinal tract caused by acid or alkaline solutions are generally limited to the esophagus and the stomach, because of physiological blocking mechanisms. In patients partially gastrectomized noxious solutions however can enter into lower parts of the gastrointestinal tract and cause severe lesions. Among 74 patients observed with corrosive lesions of the gastrointestinal tract two had undergone partial gastrectomy (Billroth II) previously. In these 2 patients very severe lesions of the intestinal mucosa were initiated; one of these patients died in spite of two resections of parts of the small intestine after massive gastrointestinal hemorrhage. These additional complications have to be foreseen in gastrectomized patients with corrosive lesions of the gastrointestinal tract.

Adult↗
PubMed1977

[Glandular cysts of the gastric mucosa. Diagnosis and a pathogenetic hypothesis (author's transl)].

Gastric polyposis was diagnosed in a 61 year old woman. Cystic deformations of the gastric glands were found on histological examination. These changes cannot be classified according to the generally accepted scheme of classification of epithelial gastric polyps. During X-ray studies a definite enlargement of the polyps could be observed under maximal stimulation with pentagastrin.

Cysts↗