Biomedical subjects

H G Struck

Publications and source records attributed to H G Struck.

At least 19 recordsLinked to original sources

PubMed2004

[Long term patency rate of the external dacryocystorhinostomy. A retrospective study in the years 1991-2000 at the University Eye Hospital in Halle].

PURPOSE: By means of a retrospective study the indication and the functional prognosis of external dacryocystorhinostomy were determined and compared with the results in the literature. METHOD: From 1991 to 2000, a total of 203 patients underwent transcutaneous dacryocystorhinostomy at the University Eye Hospital in Halle (228 operations). We evaluated to medical data and asked the patients the satisfaction with the operation, the other necessary treatments and the recent symptoms via questionnaire. RESULTS: Mean follow-up time was 3,4 years. We sent 223 questionnaires with a feedback of 146 utilizable answers (65.5%). After 121 operations (80.1%) the patients were symptom free or seldom they had a little epiphora in the wind and cold weather. 8 patients (5.5%) had scare problems. Regarding the indication of the external dacryocystorhinostomy age, gender and pathogenesis of the obstruction had no influence on the result. CONCLUSIONS: The functional success rate was 80.1% in a postoperative mean follow-up time of 3.4 years. This long term patency rate is comparable with the results for the external dacryocystorhinostomy in the literature from 80 to 100%. Other alternative surgical procedures have to measure to these high success rates.

Adolescent↗

PubMed2004

[Lacrimal system injuries -- primary and secondary surgical care].

BACKGROUND: Canalicular lacerations can be the result of sharp or blunt trauma as well as burns of the facial region. The nasolacrimal duct may become obstructed as an after-effect of naso-orbital trauma. MATERIAL AND METHODS: Main principles of surgical repair of the lacrimal system are reviewed with regard to the outcome of our own patients compared with the literature. RESULTS: Success rates in the primary repair of traumatic injuries of canalicular system are about 70 to 82 %. 14 of 20 patients who were managed between 1976 and 1980 in our department were cured permanently. 55 of 272 secondary reconstructions of canalicular obstructions (1976 - 1997) were caused by trauma. Conjunctivodacryocystorhinostomy with polyethylene or silicone tubes (1978 - 1999, n = 37, 21 traumatic) had success rates of 61 % and 72 %, respectively. 11 (4.8 %) of 228 dacryocystorhinostomies (1991 - 2000) were necessary as a result of traumatic injuries and achieved a success rate of 87.5 %. CONCLUSIONS: Canalicular lacerations need urgent primary repair with silicone intubation and special heed to the medial canthal tendon. The success rate of secondary reconstructions of traumatically caused tear-duct system obstructions depends on the microsurgical techniques that were used.

Eye Injuries↗

PubMed2001

[Is diabetes in the elderly patient a risk factor for cataracts?].

The higher prevalence of diabetes for cataracts as a component of the multifactorial genesis of age-related cataracts has been proven in several epidemiological studies. Most of these results identified diabetes as a highly significant risk factor for cataracts in older diabetic males and females. The increased cataract risk of diabetics then decreases after the age of 65 years and is related to different types of opacity. In addition to the sorbitol pathway, diabetic hyperglycaemia causes increased formation of glucose-derived advanced glycation cytotoxic end-products. In connection with these specific pathological changes, the crucial role of the lens epithelium with respect to cataractogenesis is emphasised in several studies. The results of our own prospective clinical study proved the significantly lower mean cell density in type II diabetics compared with eyes from non-diabetics. Together with the other determined morphological cell characteristics, this result seems to be due to the cataractogenic influence of diabetic metabolic disorders on the lens There are some indications for the primary cataractogenic importance of the lens epithelium in type II diabetes.

Adult↗

PubMed2001

[Indications and prognosis of dacryocystorhinostomy in childhood. A clinical study 1970-2000].

BACKGROUND: Dacryocystitis in infants is a serious complication of congenital, but seldom of acquired nasolacrimal duct obstructions. If conservative treatment fails, dacryocystorhinostomy (DCR) appears to be effective. The indications, special clinical history and results will be reviewed. PATIENTS AND METHODS: From 1/1970 to 2/2000, a total of 72 children (56 male, 16 female) with persistent dacryocystitis (18 bilateral) were treated surgically by DCR and were continuously documented. The patients ranged in age from 10 months to 14 years old (mean age 4.9 years). Included in our study were 66 children (52 male, 14 female) with 84 surgically treated lacrimal ducts (46 right eyes, 38 left eyes) who underwent control examinations. RESULTS: The cause of dacryocystitis was congenital obstruction in 63 children and trauma (maxillary fracture) in 3 children, respectively. Of these, 20 children (30.3%) had additional anomalies of the lacrimal system, 21 (31.8%) systemic malformations and 8 out of the 66 children (12.1%) had a family history of nasolacrimal duct obstruction. Since 1985 the surgical procedures have been performed under microsurgery conditions and since 1998 sometimes with a transcanalicular laser-assisted technique. We found a functional success rate (with complete resolution of symptoms) of 90.4% (76 out of 84 lacrimal ducts) over follow-up periods ranging from 1 month to 12 years (average 1.6 years). CONCLUSION: Patients with persistent dacryocystitis due to congenital nasolacrimal duct obstruction have a prevalence of further nasolacrimal abnormalities and a family history. The dacryocystorhinostomy of infants requires minimal invasive (sometimes laser-assisted) techniques. In the case of persistent dacryocystitis, DCR is indicated after the age of 1 year and has the same success rate in infants as in adults (90-95%).

Adolescent↗

PubMed2001

Comparison of 0.1% dexamethasone phosphate eye gel (Dexagel) and 1% prednisolone acetate eye suspension in the treatment of post-operative inflammation after cataract surgery.

UNLABELLED: A prospective, multi-centre, clinical parallel group study was conducted to assess the efficacy and safety of a new 0.1% dexamethasone phosphate eye gel (Group 1, n= 117) compared to 1% prednisolone acetate eye suspension (Group 2I, n=119) in a total of 236 patients (safety population), aged 39-92 years, following cataract surgery. Both drugs were given four times a day for 14 days starting 24+/-4 h after surgery. Criteria for evaluation were the reduction in anterior chamber flare and inflammation severity score (primary efficacy criteria) as well as different secondary efficacy and safety evaluation criteria. Laser photometry (LFM-500, Kowa), slit lamp assessment and the examination of other objective and subjective symptoms of ocular discomfort were performed between the last preoperative and 14th post-operative day. There were no statistically significant differences between the treatment groups concerning primary and secondary efficacy criteria. The mean reduction in anterior chamber flare from day 1 to day 14 post-operatively was 8.34+/-20.80 photons/ms with 0.1% dexamethasone eye gel and 5.72+/-16.70 photons/ms with 1% prednisolone eye suspension. The mean reduction of inflammation severity score was 1.8+/-1.3 points in Group 1 and 2.0+/-1.1 points in Group 2. Intra-ocular pressure did not increase after treatment with 0.1% dexamethasone phosphate eye gel. CONCLUSION: the results of the study underline the protective effect of topically applied 0.1% dexamethasone phosphate eye gel on the blood-aqueous barrier. This drug is an effective and safe steroidal antiinflammatory agent for topical use following cataract surgery and intraocular lens implantation.

Administration, Topical↗

PubMed2001

[Concentrations of diclofenac in aqueous humor and in plasma after i.v. injection in 59 patients undergoing cataract surgery--a prospective study].

BACKGROUND: The mean diclofenac level in the aqueous humor after i.v.-injection should be examined as an example for other systemic applied drugs. The clinical effect is to be evaluated with regard to perioperative anti-inflammatory therapy in patients undergoing cataract surgery. PATIENTS AND METHODS: In this prospective clinical study 59 patients (age 41-86 years) scheduled for phacoemulsification by the tunnel technique, received 75 mg diclofenac-sodium by short time i.v.-infusion (30 min) within an interval between 30 min and 7 h before surgery. Aqueous humor samples and one blood sample were taken at the beginning, and a second blood sample was taken at different time intervals before surgery. RESULTS: The plasma concentration of diclofenac one minute after infusion was 13,961 +/- 4277 ng/ml. The concentration decreased rapidly during the distribution phase (1305 +/- 324 ng/ml after 40 min) and reached after 336 min 419 +/- 277 ng/ml. A concentration of 83.9 ng/ml diclofenac was found for the last sampling point after 353 min in the elimination phase. The mean diclofenac concentration in the aqueous humor reached after about 60 min the highest level (21.7 +/- 12.7 ng/ml). This level decreases to 4.4 +/- 0.4 ng/ml (120 min) and 3.1 +/- 1.3 ng/ml (300 min), respectively. CONCLUSIONS: The calculated mean residence time of diclofenac molecules in aqueous humor of 123 min matched the mean disposition residence time of diclofenac in the body (119 min).

Adult↗

PubMed2001

[Human lens cells in culture. I. Isolation of adult lens epithelial cells from lens capsule preparations and reactivation of nucleus-containing fiber cells].

BACKGROUND: Bovine lens epithelial cells in culture revealed a high sensitivity against micromolar concentrations of linoleic acid. To prove the assumption that unsaturated free fatty acids are risk factors for cataractogenesis, human lens cell lines are needed. Furthermore, the reactivation of nucleus-containing fiber cells to mitotic growth may hint at their role in after cataract genesis. MATERIAL AND METHODS: Epithelium-capsule-preparations obtained by capsulorhexis were cultured in serum containing medium. Subculturing of these adult human lens epithelial cells was done by trypsinization. Fiber cell bundles from the equator region of a fetal human lens were transferred into culture medium. Aggregates of nucleus containing fiber cells were isolated from floating fiber cell bundles by trypsinization. Subculturing and cryoconservation of suitable cell lines. RESULTS: Primary culture of epithelium-capsule-preparations results in flattening, migration and proliferation of adult human lens epithelial cells. Nucleus containing fiber cells were reactivated to mitotic growth after adhesion to a suitable substratum. Established cell lines were received from adult human lens epithelial cells and fetal human fiber cells after repeated subculturing. CONCLUSIONS: Lens-capsule-preparations available from cataract surgery are well suited for the isolation of human lens cell lines, which were needed for testing cytotoxicity of drugs and for tracing of cataractogenic risk factors. The finding that nucleus containing fiber cells from the equator of human lenses can be reactivated to proliferating cells let us suppose, that these cells, which can not be removed easily from the posterior lens capsule, contribute to the after cataract formation.

Adult↗

PubMed2001

[Human cultured lens cells. II. Characterization of established lens cell lines and test of their suitability for cytotoxicity tests].

BACKGROUND: Human lens cells in culture may be valuable tools to discover cataractogenic risk factors. Here we report on the characterization of established human lens cells and their use in cytotoxicity tests. MATERIAL AND METHODS: Adhesion dependence was tested by an autoradiographic method. Soft agar test was performed to secure anchorage-independent growth. Laser scan microscopy was used for measuring the nucleus-cytoplasmic relationship. The cytoskeleton was visualized by fluorescence microscopy. Investigations on cytotoxicity were done by neutral red cytotoxicity assay and 3H-thymidine incorporation. The labeling index was determined by the BrdU-method. RESULTS: Two lens cell lines were transformed into fast growing cells. They are characterized by a partial loss of adhesion dependence, cell growth in soft agar, high cloning efficiency and reduced serum requirement. However, the nucleus-cytoplasmic relationship did not change very much in comparison to non-transformed lens cells. The organization of the cytoskeleton was cell shape dependent. The intermediate filaments were from the vimentin type. The established cell lines proved to be highly sensitive to ethanol and mitomycin C. CONCLUSIONS: The established human lens cell lines are well suited to screen for cytotoxic substances in vitro which might be cataractogenic risk factors in vivo.

Animals↗

PubMed2000

[Prognosis of conjunctivo-dacryocystorhinostomy. Modification with different implant materials].

BACKGROUND: In cases of total canalicular occlusion or the total absence of the lacrimal apparatus the functional restoration requires the repair of a newly created lacrimal system. The intraoperatively reestablisted lacrimal drainage from the conjunctival sac will be maintained by a plastic tube. Beside other criteria the influence of the used inserted materials polyethylene or silicone should be evaluated. PATIENTS AND METHODS: From 9/1978 to 2/1999 we have been treated and consecutive documented 37 cases of conjunctivodacryocystorhinostomy and its modifications in 36 patients (1mal both eyes). The patients (22 men, 14 women) ranged in age from 9-76 years (mean age of 35.2 years). In a retrospective review results were compared for the following two groups based on the type of used plastic tube: group I: (n = 23); insertion of a polyethylene tube (from 1976-1990); group II: (n = 14) insertion of a silicone tube (from 1991-1998). RESULTS: Causes of lacrimal drainage system obstruction were trauma (n = 21), malformation (n = 8), chronic inflammation (n = 5) and tumor (n = 2). The following different surgical techniques were performed: conjunctivodacryocystorhinostomy (cdr, n = 23), conjunctivodacryocystostomy (cd, n = 10) and conjunctivorhinostomy (cr, n = 4), (right eye: n = 21, left eye: n = 16). In group I 14 of 23 operations (61%) had successful functional results, in group II 10 of 14 operations (72%), respectively. The polyethylene tubes on the average were maintained for 15 months after surgery (4mal spontaneous removal) and the silicone tubes for 12 months, respectively (4mal spontaneous removal). CONCLUSION: Traumatic disturbance and congenital defects of canaliculi and surrounding tissue require in the case of any symptoms the surgical reconstruction of the lacrimal pathway. With the introduction of the silicone tube the success rate could be further advanced.

Adolescent↗

PubMed2000

[Changes in the lens epithelium of diabetic and non-diabetic patients with various forms of opacities in senile cataract].

BACKGROUND: The crucial role of the lens epithelium with respect to cataractogenesis has to be further evaluated. In this prospective clinical study, morphological characteristics of human lens epithelium in type-II diabetics and nondiabetics were examined and compared. MATERIALS AND METHODS: 30 (16 female, 14 male, mean age 73.0 years) of the overall 59 patients with age-related cataract suffering from type-II diabetes were assigned to group I and 29 nondiabetics (16 female, 13 male, mean age 68.2 years) to group II. Age, gender, type of cataract and the blood parameters fasting blood sugar and glycolized hemoglobin were further parameters. The different types of opacities (LOCS II) were summarized into 4 groups. After surgery the collected hematoxylin-eosin stained anterior central lens capsules with attached lens epithelial cells were analyzed by light microscope for the cell parameters cell density (morphometry), nucleus area (A0), nucleus volume (V), cell area (A) and nucleus-plasma-ratio. RESULTS: The mean cell density in type-II diabetics (group I) is 3691 +/- 346 cells/mm2 and in nondiabetics (group II) 4162 +/- 504 cells/mm2, respectively (p = 0.001). The total female mean cell density (4036 +/- 525 cells/mm2) was not significantly higher than the male (3788 +/- 412 cells/mm2). A decrease of the mean cell density could be attributed to age only in the nondiabetic group. With regard to the type of cataract the posterior subcapsular cataract shows the lowest mean cell density (3620 +/- 333 cells/mm2) and the nuclear cataract (4250 +/- 513 cells/mm2) the highest, respectively. The medium nucleus area and -volume and cell area are in the type-II diabetic group significantly larger than in nondiabetics. With regard to the type of cataract the posterior subcapsular opacity has the significantly largest values. The medium nucleus-plasma-ratio in type-II diabetics is lower than in nondiabetics and decreased with age. CONCLUSIONS: The significantly lower mean cell density in type-II diabetics compared with nondiabetic eyes and in posterior subcapsular cataracts in comparison with nuclear and cortical cataracts seem together with the other morphological cell characteristics to be due to the cataractogenic influence of diabetic metabolic disorder on the lens epithelium, especially in cases of posterior subcapsular opacity. These may be some clues for the primary cataractogenic importance of the lens epithelium in type-II diabetes.

Age Factors↗

PubMed2000

[Foreign body granuloma after lower eyelid avulsion and surgical revision with silicone tube splint].

BACKGROUND: Foreign-body-reactions with granulomas after use of silicone-containing biomaterials are of clinical importance [4]. HISTORY AND SIGNS: A 4-year old patient entered our hospital with a reddish vascularised tumor. The tumor's origin was in the conjunctiva of the nasal lid-angle of the right eye. THERAPY AND OUTCOME: After a traumatic disconnection of the canaliculus lacrimalis inferior, a bicanalicular silicon-tube intubation had been performed with the patient in the age of one year. Only 3 years after this intervention a secondary clinical examination could be performed. At this time, an extended solid conjunctival-tumor appeared at the operated eye. After removal and histological examination it could be classified as a foreign body granuloma. CONCLUSIONS: The blood- and tissue compatibility of silicone is only insufficiently guaranteed on the basis of the hydrophobic material-surface. After reconstructive lacrimal surgery postoperative care and the removal of the stabilizing silicone material is necessary.

Child, Preschool↗

PubMed1999

[Postoperative complications of Toti DCR (dacryocystorhinostomy. An indication for canalicular surgery].

UNLABELLED: Failures with external DCR have also been attributed to canalicular occlusion. Since 1976 we have documented all patients with surgical reconstruction of occluded canaliculi. The indication, different surgical methods of choice and functional prognosis were evaluated. PATIENTS AND METHODS: From 1976 to 1997 we have treated 272 cases. The surgical technique canaliculodacryocystorhinostomy (n = 132) was performed in 45%. Thirty operations (11%) of occluded lacrimal canaliculi due to external DCR were done. The patients ranged in age from 2 to 79 years. We examined all 29 patients (10 male, 19 female) with 30 operations (1 patient was operated on in both eyes). RESULTS: The surgical procedure was performed after an interval of 1 month to 24 years (average 4 years). Seven times a second external DCR was done. Special causes of canalicular obstruction were severe previous soft tissue and bone trauma (4 patients) and congenital defects (3 patients). Canaliculorhinostomy was performed 15 times, canaliculodacryocystorhinostomy 14 times and conjunctivorhinostomy once. Fifteen operations had good functional results (without any symptoms). Five patients had good irrigation, but a prolonged fluorescein dye disappearance test. There were 10 failures with complete closure of the canaliculi. CONCLUSION: If failure with external DCR is caused by canalicular occlusion, the microsurgical technique has a possible success rate for long-term results of about 50%. Before hand, however, all prophylactic measures have to be taken to avoid this postoperative failure.

Adolescent↗

PubMed1999

[Value of external dacryocystorhinostomy].

Present surgical techniques to distal obstruction of the nasolacrimal duct system are the external dacryocystorhinostomy (DCR) and alternatively the endonasal laser-assisted DCR and the transcanalicular laser-assisted DCR. Combining the own experiences and the overview of bibliography the different surgical techniques are compared. As criteria are used the success rate (long term patency rate), the perioperative conditions and the patient selection. The conclusion is that the success rates for conventional external lacrimal surgery are better than those for endonasal and transcanalicular laser-assisted DCR. Therefore at present the external DCR still remains the gold standard by which other methods are measured.

Dacryocystorhinostomy↗

PubMed1998

[Inflammatory reaction of the anterior eye segment. Cataract extraction in patients with and without diabetes mellitus].

BACKGROUND: We attempted to illustrate connections between selected metabolic parameters and the inflammation course in patients after cataract operations. PATIENTS AND METHODS: A prospective study comprised 64 patients aged between 35 and 88, 41 of them non-diabetics (group I) and 23 type II diabetics (group II). The following blood parameters (patients with an empty stomach) were selected for the study: cholesterol (chol), triglycerides (tri), HDL and LDL cholesterol, blood sugar (BZ), glycolized hemoglobin (HbA 1c) and C-reactive protein (CRP). To assess the course of the inflammation in the anterior chamber of the eye by objective criteria, tyndallometric measurement was used. The changes in the cornea were measured pachymetrically. The investigations were done the day before the operation and the first to third post-operative days. RESULTS: CRP was significantly different only in the males in both groups (p = 0.011). No significant differences were measured between the two groups for the blood parameters chol, tri and HDL- and LDL cholesterol. Tyndallometric measurements showed highly significantly increased anterior chamber reaction in the diabetic group (p = 0.0018). A comparison within the diabetic group did not show any significant differences between patients with or without retinopathy (p = 0.48). Comparison of diabetic patients without retinopathy with non-diabetic patients showed a clearly significant difference (p = 0.014) for this parameter. No significant pachymetric difference was found between the two groups (p = 0.49). CONCLUSIONS: The disruption in the blood-aqueous barrier and the clinical inflammatory reaction to the cataract operation are stronger in type II diabetics than in non-diabetic patients, especially in the presence of microangioorganopathy.

Adult↗

PubMed1998

[Histamine in tears in allergic rhinoconjunctivitis].

UNLABELLED: The classic clinical symptoms of allergic conjunctivitis (type I allergy)--itching and lacrimation--are the effect of histamine. Determination of histamine levels in tears may be useful in evaluating the dynamics of local histamine release in connection with the clinical findings. PATIENTS AND METHODS: Between 1.7.1994 and 31.6.1995 we analyzed the histamine levels in tears and investigated the clinical symptoms (score of 0-3) of 32 hyposensitized pollen-sensitive patients (14 males and 18 females, aged 18-45 years, group I) and of 32 controls (group II) without any allergic disease, performed in each case once in season and once out of season. Tear production and composition were measured by Schirmer's test and tear break-up time at the same time. The histamine levels of the tear samples (obtained by microcapillary method) were analyzed by electrochemical determination. RESULTS: In group I there was a highly significant increase of the mean histamine level from 0.89 +/- 2.22 ng/ml (out of season) to 7.71 +/- 7.51 ng/ml (in season) for the right eye and from 0.73 +/- 2.36 ng/ml (out of season) to 9.51 +/- 9.07 ng/ml (in season) for the left eye (P = 0.0000). The histamine level in tears of the controls (group II) was below the detection limit in all samples. The seasonal histamine level were higher with the severity of atopy (Erlangen atopy score). There was no significant influence of age and gender. The reduction of allergic symptoms during hyposensitization was not comparable to the degree of seasonal histamine level. Compared with the clinical findings, the histamine level in tears did not correlate with the symptoms of lacrimation, itching and conjunctival hyperemia. CONCLUSION: The histamine level in tears alone is not useful as a marker for the clinical severity of this atopyassociated disorder and for the efficacy of the anti-allergic therapy. After standardization of the determination method and the identification of other soluble mediators simultaneously, the histamine level in tears can be used as one part of a profile of mediators to evaluate the clinical symptoms.

Adolescent↗

PubMed1998

Simultaneous determination of diclofenac and oxybuprocaine in human aqueous humor with HPLC and electrochemical detection.

A sensitive and selective bioanalytical method for simultaneous determination of diclofenac and oxybuprocaine in human aqueous humor using reversed-phase HPLC and electrochemical detection is described. Chromatographic separation was achieved by using a Regis SPS 100 RP-8 column (5 microns; 150 x 4.6 mm I.D.). This support is coated with a hydrophilic polyoxyethylenepolymer. It allows protein-containing samples to be injected directly onto the column. The electrochemical detector permit a detection limit of 500 pg diclofenac per ml (daily relative standard deviation 6.3%) and 50 ng oxybuprocaine per ml (daily R.S.D. 2.6%), respectively. Results of administered and measured drug-concentrations in time dependent decrease are presented.

Anesthetics, Local↗

PubMed1997

[Effect of diabetes mellitus on anterior central lens epithelium in cataract patients].

UNLABELLED: The relationship between diabetic metabolic disorder and the impairment of lens epithelium in the development of age-related cataract cannot be completely defined yet. In this prospective study, morphological criteria and the phosphorus content of the anterior central lens epithelium in type-II diabetics and nondiabetics are compared. PATIENTS AND METHODS: Fifty-six of the overall 159 patients with age-related cataracts were suffering from type-II diabetes (group I) and 103 are nondiabetics (group II). In each case, a fragment of the anterior central lens epithelium was evaluated morphologically using a scanning electron microscope (S-2400) and examined by EDXA (X-ray spectrometer TN-5500), with regard to phosphorus content. The criteria considered were the degree of damage to the epithelium (score 1-3), the morphologically evaluated cell density and the "peak/background" relationship for phosphorus. RESULTS: The mean degree of damage to the epithelium was 1.48 +/- 0.53 in the type-II diabetic group (I) and 1.55 +/- 0.65 in the nondiabetic group (II), respectively. The median cell density of type-II diabetics (group I) was 4838 +/- 1033 cells/mm2 compared with 5454 +/- 1368 cells/mm2 of the nondiabetics (group II). The mean "peak/background" relationship for phosphorus was 0.46 +/- 0.20 in group I and 0.51 +/- 0.26 in group II, respectively. CONCLUSION: In the younger patients, the significant decrease in cell density and the increased degree of damage to the anterior central lens epithelium in the type-II diabetic group could be attributed to the cataractogenic influence of diabetic metabolic disorder on the lens epithelium. Another possible indication for that was the smaller phosphorus content in this group as evidence of the decrease in the biological activity of the cells (ATP-function). The primary cataractogenic importance of the lens epithelium in type-II diabetics could not be concluded.

Adult↗

PubMed1997

[Different ophthalmologic surgery irrigation solutions. Studies of postoperative inflammation].

UNLABELLED: Three different solutions, "E153", a complete electrolyte solution for intravenous infusion, as well as Alcon BSS and Alcon BSS Plus, two balanced solutions developed for eye surgery, were tested with regard to their possible effects on postsurgical inflammation progress after cataract extraction. PATIENTS AND METHODS: Seventy-four patients aged 40 to 85 years (39 female, 35 male) were included in a prospective randomized double-blind study. The following served as criteria: Comparison of the pre- and postoperative flare values by means of measurements carried out with Laser-Flare-Meter Kowa FM 500 Clinical assessment by means of a score. RESULTS: Within the limits of overall low score values of the clinical parameters, i.e. irritation of the iris (score first postoperative day: 0.6-0.8; fourth postoperative day: 0.3-0.5), irritation of the conjunctiva (score first postoperative day: 1.2-1.6; fourth postoperative day: 1.0-1.6), corneal swelling (score first postoperative day: 0.8-1.4; fourth postoperative day: 0.4-0.8) and inflammatory pseudoptosis (score first postoperative day: 1.1-1.6; fourth postoperative day: 0.8-1.6); the values of the group with E153 were higher than the values of the group with BSS and BSS Plus. The protein concentration in the anterior chamber shows a distinct increase in all three groups of patients on the first postoperative day (group 1: from 6.7 preoperatively to 14.3 ph/ms, group 2: from 6.5 to 15.1 ph/ms; group 3: from 5.4 to 17.5 ph/ms) and a continuous decrease of the tyndall until the third postoperative day (group 1: 9.1 ph/ms, group 2: 8.8 ph/ms, group 3: 13.36 ph/ms). CONCLUSIONS: Although the differences between the three groups with regard to all clinical parameters and the measurements with Laser-Flare Meter were statistically not significant, among the overall low values a favourable effect of the balanced solutions BSS and BSS Plus on postoperative inflammation was observed.

Adult↗