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Biomedical subjects

H G Worth

Publications and source records attributed to H G Worth.

At least 19 recordsLinked to original sources
PubMed1992

Comparison of low-dose intramuscular and intravenous salcatonin in the treatment of primary hyperparathyroidism.

The treatment of hypercalcaemia with low-dose salcatonin (100 U/d), administered either as a single intramuscular bolus or as a continuous intravenous infusion for five days, was examined in two groups of 10 patients with primary hyperparathyroidism, in a randomized open parallel study. Both the peak (0.31 +/- 0.035 mmol/L v 0.13 +/- 0.034 mmol/L) and overall (0.073 +/- 0.016 mmol/L v 0.018 +/- 0.016 mmol/L) hypocalcaemic responses were greater in the infusion group. The peak reduction in serum calcium occurred on day 2 of treatment after which there was a progressive attenuation of response. All the differences between the two methods of administration wer due to renal rather than bony effects of salcatonin. Possible causes of progressive resistance to treatment included reductions in sodium excretion and serum phosphate. It is concluded that low-dose salcatonin administered as a continuous infusion was more effective than the same dose given as a bolus. The kidney played a pivotal role both in the cause of the hypercalcaemia and in the response to treatment, including the rapid development of resistance which limits the use of salmon calcitonin in primary hyperparathyroidism to short-term reduction of serum calcium.

Alkaline Phosphatase↗
PubMed1990

Pseudohypophosphataemia as a result of bilirubin interference.

During the routine use of a discrete analyser it was noted that, when the serum bilirubin concentration was greater than 50 mumol/L, there was interference with serum phosphate determination measured by the formation of unreduced phosphomolybdate using a bichromatic system of measurement. The degree of interference was assessed by comparison with a reduced phosphomolybdate method (molybdenum blue). The interference cannot be removed by changing the secondary wavelength or by the use of a sample blank. It is proportional to the serum bilirubin concentration, but is not significant when this is less than 50 mumol/L. The monochromatic non-reduced phosphomolybdate method compares well with the reduced method.

Bilirubin↗
PubMed1990

Determination of reference intervals for serum magnesium.

Using a discrete analyzer and a dye-binding method, we measured magnesium in 800 patients' samples received for routine analysis. By excluding data from samples for which the calcium and (or) alkaline phosphatase values were outside defined reference limits, we established a reference interval for magnesium. Because the data showed a gaussian distribution, we could use parametric analysis to establish age-related intervals for both males and females.

Adult↗
PubMed1989

Guidelines (1988) for training in clinical laboratory management. International Federation of Clinical Chemistry (IFCC) Education Division and International Union of Pure and Applied Chemistry (IUPAC) Clinical Chemistry Division Commission on Teaching of Clinical Chemistry.

Trainees in laboratory medicine must develop skills in laboratory management. Guidelines are detailed for laboratory staff in training, directors responsible for staff development and professional bodies wishing to generate material appropriate to their needs. The syllabus delineates the knowledge base required and includes laboratory planning and organisation, control of operations, methodology and instrumentation, data management and statistics, financial management, clinical use of tests, communication, personnel management and training, and research and development. Methods for achievement of the skills required are suggested. A bibliography of IFCC publications and other material is provided to assist in training in laboratory management.

Administrative Personnel↗
PubMed1989

International Federation of Clinical Chemistry Education Division and International Union of Pure and Applied Chemistry Clinical Chemistry Division Commission on Teaching of Clinical Chemistry. Guidelines (1988) for training in clinical laboratory management.

Trainees in laboratory medicine must develop skills in laboratory management. Guidelines are detailed for laboratory staff in training, directors responsible for staff development and professional bodies wishing to generate material appropriate to their needs. The syllabus delineates the knowledge base required and includes laboratory planning and organisation, control of operations, methodology and instrumentation, data management and statistics, financial management, clinical use of tests, communication, personnel management and training, and research and development. Methods for achievement of the skills required are suggested. A bibliography of IFCC publications and other material is provided to assist in training in laboratory management.

Chemistry, Clinical↗
PubMed1989

International Federation of Clinical Chemistry (IFCC), Education Division. Guidelines (1988) for training in clinical laboratory management.

Trainees in laboratory medicine must develop skills in laboratory management. Guidelines are detailed for laboratory staff in training, directors responsible for staff development and professional bodies wishing to generate material appropriate to their needs. The syllabus delineates the knowledge base required and includes laboratory planning and organisation, control of operations, methodology and instrumentation, data management and statistics, financial management, clinical use of tests, communication, personnel management and training, and research and development. Methods for achievement of the skills required are suggested. A bibliography of IFCC publications and other material is provided to assist in training in laboratory management.

Chemistry, Clinical↗
PubMed1985

A comparison of the measurement of sodium and potassium by flame photometry and ion-selective electrode.

Although sodium and potassium have been the most commonly assayed analytes by clinical chemists for many years there have been fewer analytical principles used routinely than for most other analytes. The introduction of the direct-reading ion-selective electrode has led to a re-examination of the basic concepts of the methods involved, and this in turn to a reassessment of the interpretation of the measurement of sodium in certain clinical situations. As a result there is a case for all clinical chemistry laboratories having access to a direct-reading ion-selective electrode for sodium estimation.

Biological Transport↗
PubMed1985

Dried blood spot test estimation of urea.

The analysis of urea in serum and whole blood samples dried onto filter paper has been investigated. In both cases the sample volume is not critical nor is the volume of sample applied to the filter paper if sample discs of consistent dimensions can be punched from the dried paper. The method must be calibrated by a serum-based material not an aqueous standard, presumably because of a matrix effect. A coefficient of variation of approximately 6% has been achieved over a wide range of urea concentration and the method has been shown to correlate well with a standard laboratory procedure. The technique has a particular application to neonatal capillary samples.

Capillaries↗