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H Göing

Publications and source records attributed to H Göing.

18 recordsLinked to original sources

[Paul Ehrlich's methods for deciphering the immune defence. One method leads only to an incomplete understanding].

Paul Ehrlich's routes to decipher the immune defence came on the one side as a black box consideration from differences in the potency of the final result and on the other side from connections between the single events. In consequence of the assumption of linear interactions between the single events it was believed, as in the case of pharmacology, that Ehrlich's black box consideration from the final result could be dispensed with. The single event would be already representative for the proceedings in general. But the assumption is wrong and Ehrlich's black box consideration from the final result has to be applied again to decipher the real causes of sufficient or insufficient immune defences, of immune diseases, of allergies etc. We have to learn again, how to use two contrary considerations, which likewise have their rights, to understand the immune defence.

Allergy and Immunology↗

Immune response to extracted pollen residues.

Extracted pollen residues with three to five orders of magnitude less reextractable allergenic activity were found to be equal or better in the capacity of priming for an antibody formation in guinea pigs against the native pollen extract in comparison with the priming capacity of the native extracted material itself. Because the modification of the extract does not interfere with the run of an immune response in animals primed against the native structures of the allergen in question, the priming capacity needs attention and further optimization. Therefore this study investigated the measurement of the priming capacity of allergenic preparations.

Allergens↗