Biomedical subjects

H Göransson

Publications and source records attributed to H Göransson.

6 recordsLinked to original sources

PubMed1995

Filling the bone defect with osteogenic material. An experimental study.

In this experimental study with bone defects, we focussed on the one hand on external and internal osteogenic callus formation after filling the defect and on the other on the osteochondrogenic differentiation capacity of 4-day-old fibrous-like callus grafts and 12-day-old woven bone grafts in an osteogenic environment. A standard cortical bone defect of the femur was created in 95 young rats. The defect was filled with a cortical bone graft and 4- and 12-day-old callus grafts. The grafts were transplanted as such or in Nucleopore chambers. Follow-up was done at 1, 2, 3 and 6 weeks. The osteochondrogenic tissue formed was studied histologically and histomorphometrically. The results suggest that the filling of the bone defect had no influence on the primary external and internal osteogenic callus formation at 1 and 2 weeks. At 3 and 6 weeks in the chamber groups the persisting internal bridging woven bone was converted into more compact lamellar bone whereas periosteal callus remained at the edges of the defect. In the other groups at 3 and 6 weeks the normal shape of the cortex was reconstituting. Four-day-old fibrous-like callus formed bone in the Nucleopore chamber, indicating that fibrous-like callus tissue at 4 days contains osteogenic cells. Twelve-day-old callus consisting of woven bone was partially differentiated to cartilage, showing that woven bone contains cells capable of chondrogenic differentiation.

Animals↗

PubMed1993

Callus formation after re-injury to experimental bone defect.

Osteochondrogenic callus formation after delayed re-injury at different time intervals was evaluated. Twenty young rats were operated, and a standard bone defect reaching the medulla was sawn into the left hind leg. The rats were divided into two groups and the defect was re-created after 4 or 12 days. The rats were killed 7 or 14 days after the second operation. The developing new bone was revealed with a triple fluorochrome labelling system. The areas of bone and cartilage were measured histomorphometrically. The results suggested that an external factor, re-trauma, could increase both external and internal primary osteogenic callus formation. The optimum time to potentiate bone formation in the defects was found to be earlier than identified in previous fracture studies. After a 4-day delay the external callus was significantly larger than after the 12-day delay. Cartilage formation was not enhanced despite the sudden increase in osteogenic callus formation.

Animals↗

PubMed1993

Suprascapular nerve entrapment.

Fifty-four patients with suprascapular nerve entrapment were evaluated on an average of 5.6 years (range, 2-9 years) after surgical release. There were 32 males and 22 females. Supposed causative factor was exertion at work or vacation in 36 cases. Sixteen patients had an atrophy of the supraspinatus and 26 of the infraspinatus muscle. Conduction time to the supraspinatus muscle was 4.5 ms (range, 2.2-14.4 ms), and to the infraspinatus, 8.6 ms (range, 2.5-43.6 ms). The mean time from the onset of the symptoms to surgery was 2.8 years (range, three months to 14 years). The mean age at operation was 38.4 years (range, ten to 61 years). Two patients were operated on bilaterally within two and four years. All but two patients were operated on at the suprascapular notch. A new cranial approach is advocated. The most dramatic effect of the operation was prompt disappearance of the pain in 24 cases and marked diminishing in 15 cases (72%). At the follow-up evaluation, a moderate atrophy of the supraspinatus muscle was found only in one patient but that of the infraspinatus in 11 patients. There were ten poor long-term results, some of them presumably operated on after wrong diagnoses and some at a wrong region.

Adolescent↗

PubMed1992

Histology and histomorphometry of bone regeneration after experimental injuries.

Reparative callus formation upon tubular bone was studied after surgical injuries of different degrees. Thirty-seven young rats were divided into three groups. In the periosteum group the bone was scraped, in the fissure group we made a slit reaching the medulla, and in the defect group a standard defect was sawn. Rats were killed at 6, 12 and 18 days. The formed callus was studied histologically and histomorphometrically. The results suggest than even the primary osteochondrogenic callus formation is dependent on the mode of injury. At six days the three groups differed both qualitatively and quantitatively in regard to callus formation. At 12 and 18 days the total area of woven bone was proportional to the degree of trauma according to the linear regression line Y = 0.883 x X + 0.226 (r = 0.876, P less than 0.001). In the fissure and defect groups reparative bone filled the hole proportionally to the same extent. Periosteal and endosteal woven bone formed round the bone. Medullary bone formation was limited mainly to the area immediately adjacent to the trauma, the result being a cylinder-shaped callus. Cartilage formation was most abundant at six days and was related to the amount of woven bone in the external callus (r = 0.854, P less than 0.001) and to the trauma area (r = 0.707, P less than 0.05).

Animals↗

PubMed1991

Radiological detection of bone and bone marrow metastases.

Bone scintigraphy is the primary method for the diagnosis of skeletal metastases. This investigation is sensitive, but the interpretation must be performed in the knowledge that it is also nonspecific. Despite this, a correct diagnosis can usually be achieved. The first-hand supplementary investigation, after a doubtful scintigraphic finding, is radiography. In most cases this is sufficient for a diagnosis. When a scintigraphic abnormality cannot be adequately explained, usually because of a negative radiographic examination, a more sensitive modality must be used. Computerized tomography offers increased sensitivity and specificity, and is primarily used for this purpose. In this way contrast resolution is increased and problems caused by obscuring tissue and complicated anatomy are reduced. Since bone metastases migrate via the active bone marrow an alternative supplementary investigation is bone marrow scintigraphy. Its usefulness is restricted by disturbing activity, from the liver and the spleen, which obscures a significant part of the active marrow, and by the fact that a lesion must be of a certain size to become apparent. Magnetic resonance imaging yields excellent images of the extension of a tumor in soft tissue. Owing to high costs and restricted availability it is still mainly used for preoperative location of metastases.

Bone Marrow↗

PubMed1982

Traumatic amputations and the need for a replantation service in Finland.

The authors review a series of 290 upper extremity amputee patients injured between 1974-79 from a 400,000 population area of one central hospital. Among these amputation injuries were 55 cases which were considered "serious", i.e. effecting seriously the function of the hand. Calculations were extrapolated to obtain reliable numbers for the need of a replantation service in Finland within a population of 5 million. According to the available data 90-160 patients annually would need a replantation service for their amputation injuries inthe country. Some conclusions were also drawn about the results obtained with or without replantation surgery among the "seriously injured" group. The results obtained with the replantation service were clearly superior to the results achieved without replantation.

Adolescent↗