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H Göttinger

Publications and source records attributed to H Göttinger.

13 recordsLinked to original sources
PubMed2000

Reactions of e(-)(aq), CO(2)(*)(-), HO(*), O(2)(*)(-) and O(2)((1)delta(g)) with a dendro[60]fullerene and C(60)[C(COOH)(2)](n) (n = 2-6).

Using pulse radiolysis and laser flash photolysis, we have investigated the reactions of the deleterious species, e(-)(aq), HO&z.rad;, O(2)(*)(-) and O(2)((1)Delta(g)) with 10 water-soluble cyclopropyl-fused C(60) derivatives including a mono-adduct dendro[60]fullerene (d) and C(60) derivatives based on C(60)[C(COOH)(2)](n=2-6), some of which are known to be neuroprotective in vivo. The rate constants for reactions of e(-)(aq) and HO&z.rad; lie in the range 0.5-3.3 x 10(10) M(-1) s(-1). The d and bis-adduct monoanion radicals display sharp absorption peaks around 1000 nm (epsilon = 7 000-11 500 M(-1) cm(-1)); the anions of the tris-, tetra-, and penta-adduct derivatives have broader, weaker absorptions. The monohydroxylated radicals have their most intense absorption maxima around 390-440 nm (epsilon = 1000-3000 M(-1) cm(-1)). The anion and hydroxylated radical absorption spectra display a blue-shift as the number of addends increases. The radical anions react with oxygen (k approximately 10(7)-10(9) M(-1) s(-1)). The reaction of O(2)(*)(-) with the C(60) derivatives does not occur via an electron transfer. The rate constants for singlet oxygen reaction with the dendrofullerene and eee-derivative in D(2)O at pH 7.4 are k approximately 7 x 10(7) and approximately 2 x 10(7) M(-1) s(-1) respectively, in contrast to approximately 1.2 x 10(5) M(-1) s(-1) for the reaction with C(60) in C(6)D(6). The large acceleration of the rates for electron reduction and singlet oxygen reactions in water is due to a solvophobic process.

Carbon↗
PubMed1983

[Percutaneous nephrostomy as primary therapy of ureterovaginal fistula].

We report on our experience with 11 cases of ureterovaginal fistula primarily treated with percutaneous nephrostomy drainage. In 6 patients the fistula persisted and ureteral reimplantation with psoas hitch was performed. In 5 patients the ureterovaginal fistula closed during nephrostomy drainage. In 2 of these 5 cases a distal ureteral stricture developed and was in 1 case successfully treated by ureteral dilation under systemic corticosteroid treatment. In the second case of a ureteral stricture reimplantation was necessary. All 4 patients, that were managed without open surgery had IVP's more than a year after treatment with normal upper tracts. When ureteral reimplantation had to be performed this was an elective procedure with minimal risk and optimal preparation of the patient due to percutaneous nephrostomy drainage.

Female↗
PubMed1983

[Prostate cytology. 12 years' experience with transrectal fine needle biopsy].

From January 1970 until November 1982 7814 fine needle biopsies of the prostate were performed in 5856 patients in the urological clinic of the University of Munich. Our experience with this method demonstrates, that the technique is not as easy and must be taught carefully. The diagnostic accuracy depends mostly on the clinician who performs the procedure, less on the cytopathologist. It is possible to distinguish a normal cytological pattern as well as different degrees of infection and different types of tumour-malignancy of the prostatic cancer. Therapy-induced tumour-regression also can be diagnosed. Because of few complications and its high diagnostic reliability the method deserves increased use.

Biopsy, Needle↗
PubMed1982

[Critical observations on the current diagnostic value of prostate cytology].

Based on an inquiry it was found that aspiration biopsy and cytology of the prostate in West-Germany is practiced less than in Scandinavia. This in spite of the fact that the fine needle biopsy can be done with the same accuracy as punch biopsy of the prostate, but with more advantages. Beside of that the cytological grading proofed to be very important for the biological activity of the carcinoma of the prostate. The technique of fine needle biopsy of the prostate is not easy and must be practiced very well.

Biopsy, Needle↗
PubMed1982

[Value of urinary cytology in urological diagnosis. Report after ten years (author's transl)].

Since January 1970 to August 1981 2298 urinary cytological examinations on 1228 patients were done in the urological clinic and policlinic of the university of Munich. With this material we have examined the value of this method in urologic practice. Increasing numbers in urinary cytology point out the confidence that is placed in this technique. Primary tumors of the urinary tract can be recognized cytologically with high reliability. The diagnosis is more difficult during the first 6 months postoperatively or during chemotherapy.

Cystitis↗
PubMed1981

[Palliative nephrostomy in kidney congestion due to kidney neoplasms. Ethical aspects in decision making].

The decision to perform a percutaneous nephrostomy in a tumor patient with bilateral ureteral obstruction or not, must be taken very carefully and critically, according to the individual prognosis. It should be stressed that under certain circumstances it thoroughly corresponds with our ethical rules and the law to renounce the technical solution in favour of a humane dying.

Attitude to Death↗
PubMed1981

Enzyme immunoassay for the prostate-specific acid phosphatase (E. C. 3.1.3.2).

The clinical application of enzyme immunoassay for the determination of the prostate-specific acid phosphatase is reported. 227 sera were investigated in the diagnosis as well as in tumour monitoring and a good correlation with the clinical stage was found. In prostatic carcinomas 5 of 13 with stage T1, 11 or 12 patients with stage T2, 16 of 16 patients with T3 and 19 of 19 patients with stage T4 disease had values above 1 ng/ml. In prostatic adenomas (n = 69) in prostatitis (n = 40) and in other carcinomas of the urogenital tract (n = 28), renal carcinomas, carcinomas of the bladder and the penis) the values of the prostate-specific acid phosphatase measured by the enzyme immunoassay 131 of 137 were under 1 ng/ml. A comparison of random samples with the radioimmunoassay for this enzyme showed good correlation.

Acid Phosphatase↗
PubMed1980

[Transrectal aspiration biopsy of the prostate].

Transrectal aspiration biopsy and cytologic examination are reliable methods to diagnose a carcinoma of the prostate. However, it is not widely used in other than Scandinavian countries. The reason for this is the difficulty of using a correct biopsy technique and a good preparation of the smear. The technique is not as easy as one may think and must be taught carefully. The diagnostic accuracy depends mostly on the clinician who performs the needling, less on the cytopathologist. Cytological grading is a valuable indicator for the biological activity of a carcinoma of the prostate. Cytological follow-up of a treated carcinoma gives important information about the effectiveness of therapy.

Biopsy, Needle↗
PubMed1979

[Treatment of prostatic neoplasms].

Early stage carcinoma of the prostate is curable. Not every patient must be treated because there are significant differences in the biologic activity of the tumors. This causes a sharp difference between morbidity and mortality rate in prostatic cancer. Besides the clinical staging morphological malignancy grading is the trend factor for the treatment that has to be chosen because it has shown to be a reasonable and feasable prognostic indicator.

Adrenalectomy↗
PubMed1979

[Diagnosis of prostatic carcinoma].

Carcinoma of the prostate can be easily detected by rectal examination which is a part of the routine check-up for the early recognition of cancer in males after 45 years. Approximately 14,000 to 16,000 new cases with prostatic carcinoma are found in West-Germany annually. In former times patients with advanced carcinoma were treated with little success. Today the aim is the early detection of the disease in a curable stage. Exact clinical staging and morphological grading is fundamental for optimal therapy.

Acid Phosphatase↗