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Biomedical subjects

H Ganz

Publications and source records attributed to H Ganz.

At least 19 recordsLinked to original sources
PubMed1989

[Local antibiotic therapy of bacterial ear infections].

Local antibiotic treatment in bacteriological infections of outer or inner surfaces is more effective and less expensive than the systemic antibiotic therapy. In the ear local application of an antibiotic may be indicated in bacterial external otitis, in the suppurating radical cavity and perioperatively in chronic otitis media. - After a short survey on suitable antibiotics a study is presented, using the 0.2% solution of Ciprofloxacine for local application in bacterial external otitis (n = 34), infected radical cavities (n = 31) and external otitis complicating a chronic middle ear disease (n = 5). Dry ears, as a whole, resulted in 86%. These results were distinctly better than those obtained with systemic Ciprofloxacine treatment (63%). In pseudomastoiditis or complicating lymphadenitis a combined local and systemic Ciprofloxacine therapy was successful (n = 7). No adverse reactions were seen. - Local antibiotic treatment in the ear should be performed by the otologist, but not by the general practitioner or even the patient himself.

Administration, Topical↗
PubMed1987

[Assessing olfaction in general practice. A study of suitable odors].

We tested 15 substances, some of which have not so far been used for olfactometry, on a group of 200 normal adults and on 50 patients with impairment of olfaction. In the first stage the test substances were offered on strips of blotting paper. With this qualitative procedure 6 substances were found to be typical and well recognized. In a second stage these substances were tested quantitatively using the Elsberg olfactometer. This series revealed four groups with gradually differing olfactive activity. From each group one substance was accepted for definitive testing. These were: peppermint oil (strongest olfactory stimulus), benzaldehyde, orange oil and eugenol (weakest stimulus). Using this olfactory scale in the blotting paper test a rough quantitative screening of the degree of olfaction impairment should be possible, without recourse to expensive olfactometry.

Humans↗
PubMed1986

[Gyrase inhibitor in the local treatment of the chronically infected middle ear following surgery].

Local treatment of 20 chronic bacterial ear infections (18 infected radical cavities, 2 external otitis) with a gyrase inhibitor (Ciprofloxacin) solution led to clinical resolution in 17 cases, with elimination of the causative organisms in 16 cases. No side effects were seen, but a resistant pseudomonas developed in one case, and candida albicans in 8 others. Gyrase inhibitors such as Ciprofloxacin are antibiotics of second choice. For local treatment in the ear they should be used only in difficult cases and exclusively by the otologist. This treatment must not be used to replace proper cleaning of the ear or a necessary operation.

Administration, Topical↗
PubMed1986

[Is Malherbe calcifying epithelioma in the ENT area of a rare tumor?].

The calcifying epithelioma (pilomatrixoma) is a benign tumour of the skin originating from hair sheath cells. The head, especially the cheek and preauricular region with the parotid gland, is a very common site (about 50%). The tumour arises predominantly in younger people, with a 2:1 female to male ratio. It is not so rare as suggested by the few ENT publications. The histologic picture shows two characteristic epithelial cells, the basophilic and ghost cell. Calcification is present in most cases. The prognosis after removal of the tumour is good. Two personal cases are reported, multiple pilomatrixomas on the cheek of an 12 year old girl, and a tumour on the auricle, an unusual site.

Adult↗
PubMed1986

A contribution to indirect ophthalmotonometry in beagles.

A test of suitability of the electroimpression tonometer from Fritz Schwarzer GmbH, Munich, for measuring intraocular pressure in dogs was performed. Intraocular pressure of 63 clinically healthy English beagles was measured in both eyes using the instrument with different plunger weights. Intraocular pressure and volume of corneal depression during measurement were determined as a function of the plunger weight from readings on the tonometer with the aid of Friedenwald's tables (2). Using Friedenwald's law and with knowledge of the rigidity coefficient, an intraocular pressure of 32.7 mmHg was found, with individual variations between 12.8 and 54.2 mmHg. The rigidity coefficient for dogs, which was determined by linear regression, was, on average, 0.0103. Differences between male and female dogs were not significant for either parameter. A conversion table for eyes with a rigidity factor of 0.0103 is attached. Intraocular pressure as a function of plunger weight and the reading of measurement is shown in mmHg. In our measurements the Schwarzer electrotonometer for determination of intraocular pressure provided easily reproducible readings.

Animals↗
PubMed1979

[Postoperative mucocoeles of the maxillary sinuses (author's transl)].

The postoperative occurrences of mucocoeles of the maxillary sinuses are much rarer than those of the frontal or ethmoid sinuses. Their occurrence following Caldwell-Luc operations is 1:150. They may originate from obliteration of the sinus ostia (antritis dilatans) as well as from residuel mucosa in the upper lateral recesses of the sinus cavities. There are four clinical types of mucocoeles: (1) those which present with a swelling of the cheek, (2) those with destruction of the orbital floor with elevation of the eye, (3) those with destruction of the hard palate (which are extremely rare), and (4) those which present as multiple cysts (also rare). Among the author's 20 cases, there were 15 of the first group, 4 of the second and one of the fourth. In differential diagnosis, ameloblastoma of the maxilla must be considered. When suppuration (or pyocoele) occurs, the clinical picture may be similar to that of periorbital edema or inflammation. Operative treatment requires complete removal of the mucocoele and restoration of nasal drainage. When destruction of the orbital floor has occurred, reconstruction with a free septal cartilage graft is recommended.

Adult↗
PubMed1977

[The neurovascular island pedicle: basic considerations and its application in the face (author's transl)].

The island pedicle flap has in comparison with other skin flaps a number of important advantages which include elasticity, minimal shrinkage, absence of dog ears, success in irradiated areas and innecessity of a second stage procedure. On the head the most common donor areas for an island flap are postauricular, nasolabial, submental, and less cosmetically satisfying frontal and temporal regions. For large reconstrictions, however, only those pedicles which contain a branch of the superficial temporal or frontal arteries suffice. The major indications for an island pedicle flap include defects of the auricle, stenosis of the external auditory canal, through and through defects of the nose and paranasal region, in combination with other methods of skin grafting, and soft tissue loss and ectropion of the lower lid.

Cleft Palate↗
PubMed1976

[A contribution to the subject of the parameters PQ, QRS and QT being functions of heart rate in the ECG of the beagle dog (author's transl)].

We examined the degree of dependency of the ECG parameters PO, QRS and QT on the heart rate. In 252 beagles of standardised breeding and accommodation (strain: Chbi : BEAGLE), a total of 1456 ECG recordings was made from the three Einthoven extremity leads, and the heart rate and PQ-, QRS-, and QT-times were measured. The animals used were dogs from eleven subacute toxicity studies. 683 of the registrations were obtained from control animals and 773 from drug-treated animals whose ECG curves had remained unchanged and in which no histopathological changes were found in the heart at the end of the toxicity studies. The data obtained were biometrically evaluated by regression and correlation analyses. The range of the heart rate was 34-238 actions/min, median value 108. The range of the PQ interval was 0.07-0.18 sec, the QRS interval 0.03-0.09 sec and the QT interval 0.14-0.26 sec. The median values were 0.11, 0.05 and 0.19 sec, respectively. Positive skew distributions were found. The data were transformed to obtain values with normal distribution. The various correlation coefficients were then heart rate/PQ time: -0.408 (p less than 0.001), heart rate/QRS time: -0.057 (p less than 0.05), heart rate/QT time: - 0.611 (p less than 0.001). This means that the PQ and QT intervals clearly decrease as the heart rate increases, whereas the QRS interval is only minimally affected. Correlation ellipses were also calculated and presented graphically. These show areas within which 50, 75, 90 and 95% of our values are to be expected.

Animals↗
PubMed1975

Pupillometric studies in the beagle dog.

A method of measuring pupillary diameter in the dog using a Kowa RC-2 fundus camera, to which an eyepiece graticule had been fitted, is described. Pupil diameter was measured either directly by reading off from the calibrated graticule or from photographs. The pupillary diameters of 105 (53 male, 52 female) untreated English beagles aged between 8 and 32 months were measured under light intensities of 150-200 lux and 1000-1400 lux. Mydriatic and miotic pupillary diameters were measured in 62 male and 80 female dogs. Time-effect curves were plotted for two groups of 5 beagles receiving 75 mug/kg or 175 mug/kg atropine and 100 mug/kg or 300 mug/kg propantheline intravenously. The dose-effect curve for propantheline was found to be linear. A dose of 109 (97-121) mug/kg propantheline increased pupillary diameter by 3 mm, 20 min after administration. The time- and dose-effect curves, the significant sex differences and age dependency seen in this study indicate both a high degree of accuracy and the suitability of both of these methods for use in pharmacological and toxicological studies.

Age Factors↗
PubMed1975

[Histological examinations on the hemostatic effect of freezing during surgical procedures in the head and neck (author's transl)].

In the course of surgical interventions 28 tissue blocks of muscle, subcutis, submaxillary gland and tumors were frozen in situ, using liquid nitrogen and a closed cryoprobe. Specimens were taken before freezing, immediately after thawing, 5 minutes and 30 to 60 minutes later. They were fixed in formaline, embedded in paraffine and stained with hematotoxylineosin and after Ladewig, for better diagnosis of a possible microthrombosis. Comparing the specimens taken before and after freezing we found: no reactive vasoconstriction but dilatation, no remarkable changes of vascular wall, a moderate edema of the connective tissue, abundant bleeding, only in two of 84 sections singular microthrombi. That means no reliable criteria of an hemostatic effect of CRYOSURGery could be found histologically within the first postoperative hour, at least in case of freezing during conventional surgery.

Blood Vessels↗