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Biomedical subjects

H Gaylis

Publications and source records attributed to H Gaylis.

At least 19 recordsLinked to original sources

Are carotid body tumours malignant?

Carotid body tumours (CBTs) are slow-growing, malignant neoplasms by virtue of their local spread by continuity and contiguity and metastatic spread by lymph and blood. This article reports the findings of a pathological study of the growth characteristics of CBTs.

Carotid Body Tumor

Anastomotic aneurysms: facts and fancy.

One hundred and one anastomotic aneurysms were encountered in 74 patients over a 25-year period (1963 through 1988). Ninety-three anastomotic aneurysms (92 percent) were prosthesis-related, one followed a thromboendarterectomy, and seven (para-anastomotic aneurysms) occurred after the use of venous grafts. In the prosthesis-related anastomotic aneurysms, 50 percent of the patients had multiple anastomotic aneurysms. Most anastomotic aneurysms occurred at the femoral region (70.9 percent), but no suture line was immune. The most common cause of the anastomotic aneurysms was a defect in the host artery (90.2 percent), followed by suture failure (4.9 percent), and prosthetic failure (4.9 percent). Although most anastomotic aneurysms appeared about 5 years postoperatively, they may develop at any time. The early appearance of an anastomotic aneurysm (within 2 years) suggests infection as a cause. Because the incidence of complications of anastomotic aneurysms is high, regular follow-up assessment of all anastomoses is desirable. It is postulated that prostheses by virtue of their unphysiological characteristics cause abnormal stresses at the suture line leading to weakness of the host artery.

Anastomosis, Surgical

Management of tender abdominal aortic aneurysm.

Forty-eight patients with tender haemodynamically stable abdominal aortic aneurysms were evaluated. The aneurysms in 18 of these patients (37.5%) were found, at the time of surgery, not to have leaked. The mortality rate in patients with these tender non-leaking aneurysms undergoing emergency surgery was 16.6%. This high mortality rate can be improved by using computed tomography pre-operatively to prevent patients with non-leaking aneurysms from undergoing emergency surgery.

Aged

Presentation and management of aortocaval fistula. A report of 6 cases.

Aortocaval fistulisation is a rare condition which results in a high mortality rate if misdiagnosed before surgery. The presentation can be either acute or insidious. The paucity of definitive clinical symptoms, the haemodynamic consequences of a large arteriovenous fistula and the technical difficulties of surgery all contribute to this high mortality rate. We describe 6 patients whose case histories illustrate these points and discuss the management of patients with aortocaval fistulas.

Aged

Carotid body tumours. A review of 52 cases.

During a 22-year period (1962-1984) 52 carotid body tumours were encountered in 50 patients. In addition, 2 of the patients had tumours of the glomus intravagale. One patient had a recurrent tumour, the first one having been removed 23 years previously. The ages ranged from 23 to 80 years, the female/male ratio was 2:1, and the right side was affected twice as often as the left. Four patients were treated non-surgically; 3 were too elderly and frail to undergo the operation and in the 4th case the tumour was considered inoperable. In 2 cases excision was attempted but abandoned for technical reasons. In the remaining 44 patients 46 tumours were excised, with grafting of the internal carotid artery in 6 cases. There were 2 deaths (4.5%), 1 after hemiplegia and 1 a pulmonary embolus. Eight patients were left with cranial nerve palsy, which had been present preoperatively in 5 cases. Of the tumours 7 (13.5%) were found to be malignant. The results of endocrine studies when undertaken were normal. Although ultrasonography and computed tomography were used in some cases, arteriography was the definitive mode of investigation.

Adult

Pathogenesis of anastomotic aneurysms.

Forty-two anastomotic aneurysms were encountered in 33 patients over a 13-year period. Thirty-six occurred after the use of prostheses, and six occurred after the the use of vein grafts. In the prosthetic group, 28 aneurysmal defects were repaired, and the cause was found in 25 cases. In 23 of these cases the defect was caused by the sutures that had pulled out of the arterial wall; suture failure was recorded in only two cases. There were no defects in any of the prostheses. The suture material was braided Dacron (Tevdek) in 25 anastomotic aneurysms, but it was not recorded in three cases. In the vein graft-related group the aneurysms occurred in the "juxta anastomotic position," with the suture lines intact. They were thus true aneurysms of the vein wall. This study shows that the predominant cause of an anastomotic aneurysm in weakness of the arterial wall and not the mechanical failure of the suture material (braided Dacron) or prosthesis. It would seem, however, that the prosthesis, by virtue of its undesirable physical characteristics-a compliant mismatch with the host artery and some dilatation with the passage of time-results in abnormal shear stress at the anastomosis, leading to disruption of the arterial wall and eventually to false aneurysm formation.

Aged

The incidence of malignancy in carotid body tumours.

Twenty-three patients with 24 carotid body tumours are reviewed. A high incidence of malignancy (30%) was encountered. It is recommended that all carotid body tumours be removed unless there are contraindicating medical or technical reasons.

Adult

The hypothenar hammer syndrome.

The hypothenar hammer syndrome is manifested as digital ischaemia. It is caused by trauma to the ulnar arteries in workmen who use their hands as a mallet, and is not a rare disease. The pathophysiology of the disease is reviewed, with illustrative cases. The hypothenar hammer syndrome should be considered as a compensable injury.

Adult

Aneurysms of the renal artery with a case of extracorporeal repair.

Four patients with aneurysms of the renal artery are presented. They underwent reconstructive vascular surgery with preservation of renal function. In 1 patient the extracorporeal or 'bench-top' surgical technique was used, with cold renal perfusion and autotransplantation of the kidney to the pelvis.

Adolescent