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Biomedical subjects

H Gerl

Publications and source records attributed to H Gerl.

27 records · Page 2Linked to original sources
PubMed1986

[New aspects of the pathogenesis of acromegaly-somatoliberinomas].

According to modern knowledge, acromegaly can develop in at least three ways. A pituitary adenoma with growth hormone overproduction is the most frequent. Much rarer is ectopic growth hormone secretion by extra-hypophyseal tumors. A further possibility is the production of growth hormone releasing factor (GRF) by hypothalamic or ectopic tumors. This involves the secretion of a substance which selectively stimulates the GH producing cells of the pituitary. Special features of the clinical and morphological picture of this condition are described, based on the authors own observations. Two patients developed acromegaly: one had a retroperitoneal paraganglioma and the other a bronchial carcinoid. Ectopic GRF secretion could be confirmed radioimmunologically and immunohistologically in both cases. As a result of the on-going, tumor related GRF stimulation the patients developed nodular or diffuse GH-cell hyperplasia in the adenohypophysis. Since ectopic GH secretion does not cause hyperplasia of the adenohypophyseal cells, morphologic examination of the hypophysis can contribute to the differential diagnosis in such cases.

Acromegaly↗
PubMed1985

[Unusual abdominal apudomas. I. Cushing syndrome in association with Zollinger-Ellison syndrome in an endocrine pancreas tumor].

Ectopic production of ACTH is observed in 6% of patients with Cushing syndrome. Ten percent of these cases are related to endocrine pancreatic tumors. In a few cases a multiplicity of hormones are produced. The combination with a Zollinger-Ellison syndrome is very infrequent. In the present case, a female patient aged 54, there was an interval between the onset of Zollinger-Ellison and Cushing syndrome. The combination of bilaterally enlarged adrenals in the absence of an adrenal adenoma and the presence of Crooke-cells in the adenohypophysis in a patient with Cushing syndrome are of diagnostic significance. This trias should always alert the physician to the possibility of extrahypophyseal ACTH production.

Adrenocorticotropic Hormone↗
PubMed1983

[The endocrine pancreas in pluriglandular neoplasia type I. A report of two cases and review of the literature].

The changes of the endocrine pancreas in two cases of pluriglandular neoplasia type I were studied. A 15 year-old girl showed an amyloid containing ductuloinsular B cell adenoma, microadenomas and nesidioblastic processes. The simultaneous presence of hyperprolactinemia and nephrolithiasis indicates the existence of the endocrine polyadenomatosis. A 33 year-old woman had four amyloid containing B cell adenomas with ductular proliferation, a main cell adenoma of the parathyroid and a prolactinoma of the adenohypophysis. Solitary or multiple ductuloinsular adenomas, amyloid of the endocrine type and nesidioblastic activity are not specific features of the endocrine pancreas in pluriglandular adenomatosis. Similar structures can be found in isolated islet cell tumors or in nesidioblastosis. Ductuloinsular proliferations can also be observed in chronic pancreatitis.

Adolescent↗
PubMed1982

[Clinical value of a sensitive TSH-RIA].

Based on a sensitive TSH-RIA (measuring-range 0.2-25 mU/l, 50%-intercept 2 mU/l, coefficients of between-assay-variation 5-10%) and on nearly 1200 cases, it is demonstrated that clinical results can be received by determination of basal serum-TSH alone. Values above 0.5 mU TSH/l indicate positive TRH-tests in a good correlation between increasing basal concentrations and pituitary TSH-reserve. TSH-levels below 0.3 mU/l proceed with negative TRH-tests. In selected healthy subjects, we found all TSH-values between 0.7 and nearly 5 mU/l (means = 1.99). In euthyroid goiters, TSH-levels are normally in the same range, but in nodular goiters, subnormal values were found accumulated. TSH-levels below 0.3 mU/l are helpful to discover non-suppressibility. Hormone-treatment of goiters is successful above all in case of high-normal pretherapeutic TSH-values. "Fine-tuning" of hormone-dosage (goiter-treatment, postoperative prophylaxis, suppression-therapy in thyroid carcinoma) as well as monitoring of thyrotoxicosis-treatment is recommended to be performed by means of basal TSH-determination. In pituitary disorders, thyroid hormone-treatment seems to be necessary only at TSH-levels below 0.5 mU/l. Combination of basal TSH and total T-3 is economical and describes nearly all functional situations in diagnosis and treatment of thyroid diseases.

Goiter↗
PubMed1979

[Androgen secreting adrenal cortex tumors].

Endokrine active tumours of the adrenal cortex are rare diseases in man. Benign as well as malignant tumours of the adrenal cortex can alone excrete cortisol, aldosterone, androgens or oestrogens. More frequent are, however, tumours with a mixed incretion. Publications about tumours forming sexual hormones are above all descriptions of individual cases. After a short explanation of the most important clinical, diagnostic and therapeutic aspects on androgen-producing tumours of the adrenal cortex four own cases are discussed.

Adrenal Cortex Neoplasms↗