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Biomedical subjects

H Ghadimi

Publications and source records attributed to H Ghadimi.

At least 19 recordsLinked to original sources

Histopathological findings in cardiac transplant recipients: an assessment after 10 years' experience in Iran.

BACKGROUND: For many patients with end-stage heart failure, cardiac transplantation remains the definitive therapeutic option. The first Iranian heart transplantation was successfully performed on July 8, 1993, at Dr Shariati Hospital, Tehran. This article reports the pathology of heart transplants performed in one decade at Dr. Shariati Hospital. METHODS: All individuals who underwent heart transplantation between July 1993 and July 2003 were studied for the pathology reports of endomyocardial biopsies of heart transplant recipients. One-month, 1-year, and 5-year survival rates are also presented. RESULTS: Forty-five patients (14 females and 31 males) aged 29.6 +/- 12 years underwent heart transplantation. One-month, 1-year, and 5-year survival rates were 80%, 59.5%, and 50%, respectively. The grades of rejection were: 0 in 31 biopsies (24.2%); 1A in 27 (21.1%); 1B in one (0.8%); 2 in 21 (16.4%); 3A in 34 (26.6%); 3B in 9 (7%); 4 in four specimens (3.1%), and one biopsy was inadequate (0.8%). A Quilty B effect was observed in one specimen (0.8%), but a Quilty A effect, cytomegalovirus or toxoplasmic myocarditis, or previous biopsy sites were not observed. CONCLUSION: Survival rates of heart transplant recipients were lower compared with the international statistics. The incidence and severity of rejection episodes were higher among our patients. These findings may be due in part to the noncompliance of heart transplant recipients with the follow-up biopsy schedules, leading to late detection of rejection episodes.

Adolescent↗

Microbiological and epidemiological study of streptococcal sore throat at a children's clinic: a one-year study.

From October 1973 to September 1974, throat cultures were taken from 578 patients who referred to the Children's Clinic with upper respiratory tract infection. One hundred fifty-one (26%) of the sick children yielded beta-hemolytic streptococci and 427 (74%) of the pharyngitis cases were considered as viral. The most susceptible ages for streptococcal and viral pharyngitis were 5-8 and 2-6 years respectively. The peak seasonal incidence for streptococcal sore throat was from late autumn to early spring. There was a positive correlation between the incidence of upper respiratory infection and streptococcal isolation. From 100 strains of beta-hemolytic streptococci isolated and tested, 86 were group "A", 4 group "C", 2 group "G" and 8 non-groupable. From 86 group "A" strains. 71 (82%) were typable by agglutination ("T"-typing), but only 49 (57%) by precipitation ("M"-typing). The most prevalent "M" types were types 1 and 12. There was 95% correlation between serological and bacitracin disk method for grouping of hemolytic streptococci. All strains isolated were sensitive to penicillin, erythromycin and chloramphenicol, but 11 strains were resistant to tetracyclin.

Age Factors↗

[The improtance of endogenous amino acid losses in diarrhea in infants].

Protein depletion is introduced as a unitary concept in the progression of acute infantile diarrheas into a protracted or intractable stage. It has been shown that in acute infantile diarrhea significant amounts of endogenous nitrogen are lost through the stool. Accumulated loss beyond a week or so may interfere with regeneration of intestinal mucosa and the synthesis of digestive enzymes. The success of total parenteral alimentation in the management of intractable diarrhea supports this theory. As a relatively simple preventive measure, the administration of amino acid solution by peripheral vein, concomitantly with glucose, is suggested in the management of the early stages of infantile diarrhea.

Amino Acids↗