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Biomedical subjects

H Gi

Publications and source records attributed to H Gi.

At least 19 recordsLinked to original sources
PubMed1999

[A case of Morgagni's foramen hernia difficult to differentiate from lipoma].

A 61-year-old woman was admitted for chest discomfort. She had been admitted before, in March 1995, because of a lesion detected on chest roentgenograms. At that time, she was given a diagnosis of mediastinal lipoma based on the findings of chest computed tomography (CT) and magnetic resonance imaging (MRI), but was discharged without active intervention due to lack of subjective symptoms. During follow-up, the patient again reported chest discomfort beginning in March 1998. Because chest radiography disclosed. The tumor had enlarged, the patient was admitted to the hospital by our department. Chest MRI disclosed a mass with a signal intensity equal to that of subcutaneous fat in the pericardial space on both T1-weighted and T2-weighted images. Although sagittal images demonstrated continuity of the mass into intraperitoneal fat, a conclusive diagnosis of diaphragmatic hernia could not be made at that time. On April 30, 1998, a thoracotomy was performed on the basis of a preoperative diagnosis of mediastinal lipoma. During surgery, a hernial ring was observed slightly to the right and behind the sternum. The hernia consisted only of greater omentum, and was diagnosed as Morgagni's foramen hernia.

Diagnosis, Differential↗
PubMed1998

A randomized, prospective, comparative study of manual and automated renal biopsies.

A percutaneous renal biopsy can be performed in several ways, including using a spring-loaded biopsy gun. As this form of renal biopsy has become more popular, a controversy has developed regarding tissue adequacy and the incidence of complications. To compare these two aspects in an automated biopsy and a manual biopsy, we studied 166 patients assigned to one of the two renal biopsy methods. In a randomized, prospective manner from June 1994 until February 1997, group 1 (67 patients) received a 14 G Tru-cut needle (Baxter, Deerfield, IL) manual biopsy while group 2 (99 patients) received an 18 G automated gun biopsy. There was no difference in sex, age, hemoglobin level, prothrombin time, partial thromboplastin time, or diastolic and systolic blood pressure prebiopsy in groups I and II. Indications for biopsy were proteinuria (38%), proteinuria accompanied by hematuria (31.3%), acute renal failure (9.6%), lupus nephropathy (9.6%), chronic renal failure (6%), and hematuria only (5.4%). In group I, the number of cores was 1.88 +/- 0.56, the glomeruli obtained were 27.3 +/- 13.8, and the number of glomeruli per core were 15.3 +/- 8.4. In group II, the values were 2.37 +/- 0.88, 20.7 +/- 11.1, and 9.95 +/- 6.9, respectively. These results showed a statistically significant difference (P < 0.05). In all cases, pathological diagnosis was possible. The histology showed IgA nephropathy in 25.9%, minimal change disease in 16.3%, lupus nephritis in 11.4%, membranous glomerulonephropathy in 9.3%, membranoproliferative glomerulonephritis in 5.4%, and others. The incidence of postbiopsy hematoma was marginally greater in group I (22.3% v 11.1%) and the area of perirenal hematoma shown on ultrasound 24 hours postbiopsy was larger in group I, as well (848 +/- 623 mm2 v 338 +/- 260 mm2). Hematocrit levels before and after biopsy showed a significant difference (34.9% +/- 7.9% and 34.0% +/- 7.6%, respectively; P < 0.05) in group I, but no significant difference was observed in group II (35.1% +/- 7.0% and 34.7% +/- 6.9%). Both techniques rendered adequate tissue sampling, but the extent of bleeding was more severe with the manual 14 G Tru-cut needle biopsy.

Acute Kidney Injury↗
PubMed1996

[A case of mucoepidermoid carcinoma underwent middle and lower sleeve bi-lobectomies with carinal reconstruction].

A case of mucoepidermoid carcinoma was successfully resected by bronchoplasty with carinal resection. A 36-year-old male complaining cough and sputum was admitted to our hospital. Bronchofiberscopical examination revealed a tumor mass occluding the truncus intermedius. The tumor seemed to invade the carina, but the orifice of the right upper lobe bronchus was intact. The results of the pathological examination of the biopsy specimen showed mucoepidermoid carcinoma. Sleeve middle and lower lobe bi-lobectomies with carinal reconstruction were successfully performed. The postoperative course was uneventful. The patient is alive 5 year and 5 months after operation without recurrent tumor.

Adult↗
PubMed1994

[Spinal cord stab injury by acupuncture needle: a case report].

It is very rare for neurosurgeons to encounter cases of spinal cord injury caused by a broken acupuncture needle. A 45-year-old man was referred to our clinic because of urinary retention about two weeks after acupuncture therapy (a needle was broken during treatment). The patient showed no motor weakness, or sensory disturbance. The needle was seen transversely stabbing the spinal cord at C1/2 on CT imaging and X-ray film. In all of the reported seven cases of longitudinal stab injuries (posterior puncture), sensorimotor disturbances were present. In transverse stab injuries (lateral puncture), however, two cases did not show motor weakness but sensory disturbance. The centrifugal pathway for micturition in the spinal cord lies in the middle one third of the lateral columns and in the width of the central canal. The patient complained of urinary retention because the bilateral descending fibers might have been stabbed by the needle. Surgical treatment relieved the patient from his complaint.

Acupuncture Therapy↗
PubMed1994

[Targeting therapy for lung cancer].

Many approaches have been developed to targeting therapy for lung cancer. The representatives types have included photodynamic therapy (PDT), bronchial arterial infusion of anticancer agent and/or embolization, intensification of the effect of drugs on tumor tissue and drug delivery systems (DDS) using liposomes. In our hospital, 195 lung cancer patients, including those with 56 early stage lesions, have been treated with PDT, and a CR rate of 65.2% was obtained. Bronchial arterial infusion (BAI) for clinical N2, in-operable non-small cell lung cancer patients has prolonged median survival time compared to the patients treated without BAI. Combined modalities of chemotherapy and low power laser (He-Ne Laser) irradiation in the experimental animal model have been shown. This combined therapy may permit enhancement of the antitumor effects of routine chemotherapy by reducing the side effects of the drug. DDS using liposomes may well be a major targeting therapy for lung cancer. In our data, trans-bronchial injection of chemotherapeutic drugs encapsulated with liposomes will be most effective for mediastinal lymph node metastasis of lung cancer.

Bronchial Arteries↗
PubMed1993

[Carcinoid tumor of the thymus].

Carcinoid tumor of the thymus is a rare tumor. It is difficult to detect thymic carcinoid tumors by conventional chest X-ray films. As a result many cases of thymic carcinoid tumor are discovered at an advanced stage. While it is difficult to make a definitive pathological diagnosis preoperatively, percutaneous needle biopsy by Surecut needle is possible. Median sternotomy is better than thoracotomy, as thymectomy and lymph nodes dissection are necessary. Of the 6 cases of thymic carcinoid tumors, 5 were diagnosed as atypical carcinoid histologically, and in 3 of those 5 cases lesions resembling small cell carcinoma were observed in some specimen. The causes of these advanced atypical thymic carcinoid cases were not good.

Adult↗
PubMed1991

[Subfrontal schwannoma: a case report].

A case of a 63-year-old woman with subfrontal schwannoma of the left side is presented. The patient had a two-month history of recent memory disturbance and unstable gait. Computed tomography represented an isodense mass lesion with large and small cystic components in the anterior cranial fossa, enhancing homogeneously after intravenous injection of contrast medium. Cerebral angiograms revealed a noticeable hypovascularity. She underwent total resection of the tumor on May 21, 1986. It was verified that the tumor was attached to the left olfactory groove and had invaded the ethmoid bone. It was suggested that this tumor arose from one of the meningeal branches of the trigeminal nerve or of the anterior ethmoid nerve. Histological examination proved that this neoplasm was of schwannoma.

Brain Neoplasms↗
PubMed1990

Meningioma with hypergammaglobulinemia. Case report.

The case of a 14-year-old boy presenting with hypergammaglobulinemia (immunoglobulin (Ig)G and IgA) and a cerebellopontine angle tumor is reported. The tumor was histologically confirmed as meningioma infiltrated with plasma cells, lymphocytes, and histiocytes. Immunohistochemical studies showed that the infiltrating plasma cells were stained by antibodies to IgG and IgA. After total tumor removal, the hypergammaglobulinemia immediately resolved. A plausible interpretation of this sequence of events is that the inflammatory cell reaction to the meningioma caused the immunological response followed by an unusual hypergammaglobulinemia.

Adolescent↗
PubMed1990

[C-P angle epidermoid carcinoma: a case report].

The patient, a 39-year-old man, underwent initial surgery for total removal of a left C-P angle tumor histologically diagnosed as epidermoid carcinoma. Postoperative irradiation therapy was administered over the whole brain and spinal cord, 50 Gy and 20 Gy respectively. The patient was then released without symptoms. 15 months later, he was readmitted for paraparesis and urinary retention. CT scan revealed no tumor recurrence in the intracranial area but did show intraspinal cyst of the lower thoracic level. After cyst-subarachnoid shunt, severe acute hydrocephalus was shown on CT scan. His general condition progressively deteriorated. Ten days after the shunt operation, he died of systemic bleeding tendency and cachexia. During surgery, the authors obtained dark yellowish fluid from the intraspinal cyst. Gene survey of the specimen from the cyst wall disclosed abnormality. It is important in the diagnosis of primary intracranial epidermoid carcinoma that we rule out the existence of extracranial cancer and direct invasion through the dura. Though epidermoid carcinoma can be fatal, radiotherapy was an efficacious treatment in the present case, as well as in three other reported cases.

Adult↗
PubMed1988

[A successful treatment of giant carotid artery aneurysm by a detachable balloon technic; a child case].

For the treatment of unclippable giant carotid artery aneurysms, proximal occlusion of the carotid artery is still an accepted treatment by surgical ligation, Selverstone clamp, or detachable balloon. However, proximal artery occlusion should be avoided as far as possible. Use of detachable balloons for proximal artery occlusion in the treatment of giant intracranial aneurysm in children has been reported by several authors, but no report of successfully treated cases of occlusion of the aneurysm without occlusion of the parent artery can be found. On January 1st, 1987, a-5-year old girl was admitted to our clinic with chief complaints of exophthalmos and loss of vision in her left eye. On admission, neurological examination showed palsies of the left oculomotor and abducens nerve and left internal carotid angiogram visualized a giant aneurysm in the cavernous portion. A balloon catheter procedure was carried out under general anesthesia using an intra-arterial catheter technique. A No. 9 French introducer catheter was placed through the femoral artery sheath. No filling of aneurysm without occlusion of the parent artery could be confirmed by angiogram. No. 12 Debrun detachable balloon was then detached. Postoperative course was uneventful. Subsequently, her oculomotor and abducens nerve palsies disappeared. Digital subtraction angiography taken about three months after the procedure showed complete occlusion of the aneurysm. The authors emphasized that the occlusion of the aneurysm using a detachable balloon was also the ideal method for the treatment of the children's giant aneurysm.

Carotid Artery Diseases↗
PubMed1984

Growth-inhibitory effect of prostaglandin D2 on mouse glioma cells.

The effects of prostaglandin D2 (PGD2) on the growth of mouse malignant glioma cells were studied in vitro and in vivo. The in vitro studies consisted of various concentrations of prostaglandins (PG's) being added to cultures of mouse glioma cells. At concentrations above 2.5 micrograms/ml, PGD2 strongly inhibited the proliferation of glioma cells, whereas PGE2 had no effect at the same value. Exposure to 5.0 micrograms/ml PGD2 for more than 2 hours resulted in inhibition of glioma cell proliferation. This growth-inhibitory effect of PGD2 was related to the inhibition of DNA synthesis of the cells. The in vivo studies were performed with a subcutaneously transplanted mouse glioma model. Injection of 0.5 mg/kg PGD2 into the tumor was more effective than the same concentration given by intraperitoneal injection. In mice with intracranially transplanted glioma, daily intraperitoneal injection of 0.5 mg/kg PGD2 had no significant effect on survival time.

Animals↗
PubMed1984

[Synergism of hyperthermia and hematoporphyrin derivative].

Much attention has been given to the photoradiation therapy, since its mechanism of effect is thought to be due to the cytotoxicity of singlet oxygen produced from hematoporphyrin derivative (HPD) by the light. We studied the effects of hyperthermia (HT) on cultured cells (T1) of ethylnitrosourea induced rat brain tumor which had uptaken HPD, because the extent of photopenetration is limited and the absorbed light is converted to heat. We used the T1 cells preincubated in Eagle MEM with 10% FCS and 2 micrograms/ml HPD, and estimated the cell survival by the colony formation using soft agar overlayer method. Synergistic effects of HT and HPD were recognized at the temperature over 41.5 degrees C-HT, suggesting that combined HT and HPD therapy could be a new promising technique. In these experiments, an increased cell proliferation was observed after temporary suppression by "insufficient hyperthermia" at 41.5 degrees C. This is a kind of rebound phenomenon, which has an important clinical implication. We should pay attention not only to the cell damage by HT but also to the outcome of the therapy which have received insufficient HT.

Animals↗
PubMed1983

[Brain abscess: successful treatment of 4 cases including one with ventricular perforation].

The authors experienced with four cases of brain abscess, one of which ruptured into the lateral ventricle. Two cases were treated conservatively and the remaining two were treated surgically. All cases recovered satisfactorily. Case 1: A 30-year-old man with congenital cyanotic heart disease was admitted on Oct. 4, 1979, because of convulsion. Physical examination revealed motor aphasia, right hemihypesthesia, cyanosis, clubbed finger and continuous heart murmur. CT scan showed a ring-enhance mass lesion in the left temporal lobe. Although transient deterioration of the clinical course was observed, he improved satisfactorily after medical treatment of 20 days. Case 2: A 54-year-old man with left homonymous upper quadrantanopia and systolic heart murmur was admitted on Sept. 17, 1979. alpha-streptococcus was detected in the culture of his arterial blood. Vegetation near the mitral valve was revealed by ultrasonic cardiogram. CT scan showed an irregular and ill-shaped ring-enhanced mass in the left temporoparietal region. A saccular aneurysm in the insular portion of the posterior parietal artery was seen on the left carotid angiogram. He was also treated medically and the abscess was gradually reduced and the aneurysm disappeared. Case 3: A 28-year-old man complaining of headache, nausea and vomiting was admitted on Dec. 1, 1979. Physical examination revealed nuchal stiffness, right homonymous hemianopia and bilateral choked disc.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗