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Biomedical subjects

H Gisslén

Publications and source records attributed to H Gisslén.

18 recordsLinked to original sources
PubMed1992

Treatment of aggressive basal cell carcinoma with intralesional interferon: evaluation of efficacy by Mohs surgery.

BACKGROUND: Intralesional interferon has shown activity in the treatment of noduloulcerative and superficial basal cell carcinomas (BCC). OBJECTIVE: Our purpose was to study the efficacy of intralesional interferon in the treatment of aggressive BCCs. METHODS: Fifteen patients with histologically proven primary morpheaform or recurrent BCCs were referred for Mohs surgery. They received nine intralesional injections of 1.5 million IU of interferon alfa-2b three times a week for 3 weeks (total dose 13.5 million IU). All tumors were located on the face and measured 7 to 25 mm in diameter. RESULTS: In four patients (27%) no residual tumor was found at surgery. In five (33%) tumor size was reduced by 75%. The remaining six patients (40%) showed no response to intralesional interferon. CONCLUSION: At the dosage used, interferon was able to cure only a minority of aggressive BCCs.

Aged↗
PubMed1989

Trichophyton rubrum abscesses in immunocompromised patients. A case report.

A 72-year-old immunocompromised man with myelodysplastic syndrome who developed multiple erythematous, scaly abscesses like lesions on his left foot and lower leg is described. He also had dry scaly lesions on his soles and lesions on several toe nails. A punch biopsy showed abscesses with fungal elements and Trichophyton rubrum was cultured from skin scales and the biopsy. A diagnosis of T. rubrum abscesses should be suspected in all immunocompromised patients with signs of superficial dermatophyte infection.

Abscess↗
PubMed1988

Curettage of molluscum contagiosum in children: analgesia by topical application of a lidocaine/prilocaine cream (EMLA).

The analgesic effect of a lidocaine/prilocaine cream (EMLA) for the curettage of molluscum contagiosum was evaluated in 55 children aged 3-14 years. Five to 25 molluscs per child were covered with a maximum of 10 g EMLA cream one hour before the operation. The pain was rated as either none or slight by 93% of the children while the physician's assessment was 96%. On a 100 mm Visual Analogue Scale (VAS) where 0 represented no pain and 100 severe pain, the median rating by the children was 3 mm. Mild vasoreactions such as pallor, redness or oedema were observed locally at the treated skin areas. The results show that EMLA cream provided effective local anaesthesia for the curettage of molluscs.

Administration, Cutaneous↗
PubMed1987

Identification of basal cell carcinomas by means of monoclonal antibodies C50 and C241.

The monoclonal antibodies C50 and C241 with specificities for the carcinoma-associated carbohydrate structures sialylated Lea and sialosyllactotetraose, respectively, were used in the indirect immunofluorescent test for demonstration of malignant cells in patients with basal cell carcinoma (BCC). Among a total of 36 patients with BCC, 33 were positive with the MAb C50, and 30 with the MAb C241. All of five patients with premalignant conditions were positive with both antibodies, whereas none of 31 control individuals (biopsies from normal skin or from patients with non-malignant conditions) showed a positive reaction. It is suggested that the technique described may provide a convenient tool for evaluation of samples obtained by microscopically controlled surgery of BCC as well as being an adjunct to conventional light microscopy in pathologic-anatomic diagnosis of potentially malignant disease of the skin.

Antibodies, Monoclonal↗
PubMed1975

Histological and histochemical investigations of lupus erythematosus in the skin and the oral mucosa.

Skin and oral lesions of chronic discoid lupus erythematosus from 6 patients have been investigated histologically and histochemically. Intra-individual comparisons between skin and oral lesions and intrasection comparisons between clinically affected and unaffected regions were performed. Enzyme histochemical recordings consisted of oxido-reductase and hydrolase activities. A high degree of correlation was noted in the intra-individual comparisons. The intrasection comparisons provided information concerning metabolic dynamics of the disease. The data obtained support the view that serious vascular changes are involved in the development of the changes in the overlying epithelium. The enzyme histochemical results agreed generally with histological data and proved to be a valuable diagnostic aid.

Acid Phosphatase↗