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H Glasner

Publications and source records attributed to H Glasner.

10 recordsLinked to original sources
PubMed1979

Diagnostic value of brief microzone electrophoresis of unconcentrated CSF and agar gel electrophoresis of concentrated and unconcentrated CSF.

This paper reports a comparison between brief microzone electrophoresis and agar gel electrophoresis of CSF proteins; 41 different CSFs were examined simultaneously by all three methods. Fractionation of gamma-globulins was found by brief microzone electrophoresis in 53.7% of unconcentrated CSF. This fractionation was found in 63.4% of unconcentrated CSF after agar gel electrophoresis, in 48.8% of concentrated CSF. Serum-like pherogram and the rapid alpha-globulin type were found equally often.

Cerebrospinal Fluid Proteins↗
PubMed1978

[Diagnostic value of microzone electrophoresis of non-concentrated cerebrospinal fluid (author's transl)].

Results of microzone electrophoresis and immunochemical examination of proteins in nonconcentrated CSF were compared. Blood-CSF barrier impairment, disturbances in CSF flow and immune reactions were detectable by the microzone electrophoresis technique. Blood-CSF barrier impairment and immune reactions were detected by immunochemical determination of albumin and IgG on LC partigen plates, the assay range of the plate being sufficient only for these proteins. There was no significant difference in the frequency with which abnormal protein values were found by either method.

Albumins↗
PubMed1978

Microzone electrophoresis of the unconcentrated and concentrated CSF.

Concerning the small methodical range of error and the little expenditure of work microzone electrophoresis of the non-concentrated CSF after staining with nigrosine and after evaluation on non-transparent acetate film should have priority to microzone electrophoresis of concentrated CSF. This paper reports a comparison of microzone electrophoresis of non-concentrated and concentrated CSF.

Central Nervous System Diseases↗
PubMed1978

CSF circulation and blood-CSF barrier.

Results of microzone electrophoresis of non-concentrated CSF after staining with nigrosine and after evaluation on non-transparent acetate film are compared with those of isotope cisternography (111In-DTPA). We found that blood-CSF barrier disturbances begin with an increase of the absolute values of prealbumins in normal CSF circulation. When a barrier impairment occurs, by first increasing the absolute values of alpha1-globulins, we state a pathological CSF circulation. In this case, most of the globulin region is pathologic (globulin-type).

Albumins↗
PubMed1976

[Blood-C.S.F. barrier impairment in multiple sclerosis (author's transl)].

Cerebrospinal fluid (C.S.F.) findings of 68 patients in multiple sclerosis in relation to the length of illness are reported. Immune reactions in the C.S.F. are similar to those reported by other research workers. In the first 10 years illness an increasing blood-C.S.F. barrier impairment can be noticed. Similar C.S.F.-diagnoses, immune reaction and barrier disturbance, are also possible in acute and severe stages of multiple sclerosis. Consequently, barrier impariment during a severe reaction in the C.S.F. in multiple sclerosis can be an indicator of an increase of pathomorphological C.N.S.-changes which is possible in the first 10 years of illness.

Acute Disease↗
PubMed1975

[Patho-physiological aspects in csf proteins (author's transl)].

Electrophoresis and immunoelectrophoresis of cerebrospinal fluid of 201 patients with inflammatory CNS diseases revealed that over a total protein value from 0 to greater than 1, 2 g/1 there was merely a decrease in pre-albumins and a difference in the gamma-globulins as a pointer to immune reactions. Comparison with the absolute values indicated an increase of all fractions in inflammatory and non inflammatory diseases caused by impairment of the blood-CSF barrier. Again there was evidence of immune reaction in the gamma-globulin range. Impairment in the blood-CSF barrier was demonstrated by an increased concentration of IgG, IgA and IgM. An immune reaction was revealed by higher IgG values.

Blood-Brain Barrier↗
PubMed1975

Barrier impairment and immune reaction in the cerebrospinal fluid.

Investigations on pathophysiological processes in the CSF space due to impairment of the blood-CSF barrier and due to an immune reaction are reported. Barrier disturbances and immune reaction are demonstrated by means of absolute values of CSF protein electrophoresis and by measurement of immunoglobulins. With inflammatory diseases of the CNS, an altered blood-CSF barrier will often be seen at the moment of the first lumbar puncture. Multiple sclerosis, subacute leucoencephalitis and neurosyphilis show signs of a distinct immune reaction together with an increase of the gamma-globulins as well as the immunoglobulin G in the absence or slight presence of a barrier impairment. Non-inflammatory diseases of the CNS have variable barrier disturbances.

Albumins↗